The Communicative Cardiac Cell

by Sideman, Samuel; Beyar, Rafael; Landesberg, Amir

• ISBN13: 9781573315487
• ISBN10: 1573315486
• Edition: 1st
• Format: Paperback
• Copyright: 2005-06-24
• Publisher: Wiley-Blackwell

Summary

The basic phenomena of intra- and intercellular communication and the transport signals within and between the cells controlling cardiac function are described and discussed in this volume. The amazing synchronization of millions of cells and billions of nanoscale molecular motors, ion gates, and ion pumps assure normal cardiac function; whereas disharmony and local transport and signal disruptions are the forecasters, and eventual causes, of pathologic conditions and heart failure.Although this volume concentrates on basic phenomena, strong emphasis is given to the related clinical and pharmaceutical manifestations, and chapters have been contributed by molecular biologists, pharmaceutical experts, and cardiac scientists.This volume will promote better understanding and, consequently, better clinical and pharmaceutical handling of the various aspects of cardiac pathophysiologies associated with electrical, mechanical, and metabolic and circulatory disorders in the cardiovascular system.NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas.ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit www.nyas.org/membership/main.asp for more information about becoming a member.

Author Biography

Samuel Sideman, Rafael Beyar, Amir Landesberg

All of the Israel Institute of Technology, Haifa, Israel

Table of Contents

Preface: The Cellular Communications Maze

Prologue

From Organ to Molecules: Steps and Consequences

Cardiac Cell Development

Evolution of the Heart from Bacteria to Man

The Miscommunicative Cardiac Cell: When Good Proteins Go Bad

Multiple Stem Cell Populations Contribute to the Formation of the Myocardium

Differentiation Pathways in Human Embryonic Stem Cell-Derived Cardiomyocytes

Functional Properties of Human Embryonic Stem Cell-Derived Cardiomyocytes

Calcium Signaling

The Assembly of Calcium Release Units in Cardiac Muscle

Calcium Signaling in Cardiac Ventricular Myocytes

Calcium Biology of the Transverse Tubules in Heart

Multimodality of Ca2+ Signaling in Rat Atrial Myocytes

Effects of Na+-Ca2+ Exchange Expression on Excitation-Contraction Coupling in Genetically Modified Mice

Mitochondrial Calcium Signaling and Energy Metabolism

Rhythmic Ca2+ Oscillations Drive Sinoatrial Nodal Cell Pacemaker Function to Make the Heart Tick

Intracellular Signaling

Modification of Cellular Communication

Caveolae and Lipid Rafts: G Protein-Coupled Receptor Signaling Microdomains in Cardiac Myocytes

Nitric Oxide and the Heart: Update on New Paradigms

Cardiac Neurobiology of Nitric Oxide Synthases

The Murine Cardiac 26S Proteasome: An Organelle Awaiting Exploration

Energetics and Transport

Metabolic Energetics and Genetics in the Heart

The Sarcomeric Control of Energy Conversion

Structure-Function Relation of the Myosin Motor in Striated Muscle

Mitochondria and Ischemia/Reperfusion Injury

Regulation of Cardiac Energetics: Role of Redox State and Cellular Compartmentation during Ischemia

Spatial Regulation of Intracellular pH in the Ventricular Myocyte

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