Comparative Genomics: Basic and Applied Research

by Brown; James R.

• ISBN13: 9780849392160
• ISBN10: 0849392160
• Edition: 1st
• Format: Hardcover
• Copyright: 2007-12-03
• Publisher: CRC Press

Summary

When genomic research first came on the scene, much of the biomedical research community viewed it as a limited venture with limited potential. We now know that such an assessment was both premature and inaccurate. In the last ten years, we've witnessed such remarkable acceleration in the merger of basic and applied genomic research that, among other things, genomic research is now thought of as being intrinsic to current drug research. Through rigorous comparative analysis, the genomes of cold-blooded vertebrate, avian, and other mammalian species are providing a deeper understanding of the human genome. This is leading to the development of drugs that may well treat a number of otherwise intractable conditions.

Table of Contents

Preface	p. vii
Editor	p. xi
Contributors	p. xiii
Introduction The Broad Horizons of Comparative Genomics	p. 1
Basic Research in Comparative Genomics
Advances in Next-Generation DNA Sequencing Technologies	p. 13
Large-Scale Phylogenetic Reconstruction	p. 29
Comparative Genomics of Viruses Using Bioinformatics Tools	p. 49
Archaebacteria and the Prokaryote-to-Eukaryote Transition (and the Role of Mitochondria Therein)	p. 73
Comparative Genomics of Invertebrates	p. 87
Comparative Vertebrate Genomics	p. 105
Gaining Insight into Human Population-Specific Selection Pressure	p. 123
Applied Research in Comparative Genomics
Comparative Genomics in Drug Discovery	p. 157
Comparative Genomics and the Development of Novel Antimicrobials	p. 177
Comparative Genomics and the Development of Antimalarial and Antiparasitic Therapeutics	p. 193
Comparative Genomics in AIDS Research	p. 219
Detailed Comparisons of Cancer Genomes	p. 245
Comparative Cancer Epigenomics	p. 261
G Protein-Coupled Receptors and Comparative Genomics	p. 281
Comparative Toxicogenomics in Mechanistic and Predictive Toxicology	p. 299
Comparative Genomics and Crop Improvement	p. 321
Domestic Animals A Treasure Trove for Comparative Genomics	p. 341
Index	p. 363
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