Comprehensive Chiroptical Spectroscopy, Volume 2 Applications in Stereochemical Analysis of Synthetic Compounds, Natural Products, and Biomolecules

by Berova, Nina; Polavarapu, Prasad L.; Nakanishi, Koji; Woody, Robert W.

• ISBN13: 9781118012925
• ISBN10: 1118012925
• Edition: 1st
• Format: Hardcover
• Copyright: 2012-03-27
• Publisher: Wiley

Summary

This book provides an introduction to the important methods of chiroptical spectroscopy in general, and circular dichroism (CD) in particular, which are increasingly important in all areas of chemistry, biochemistry, and structural biology. The book can be used as a text for undergraduate and graduate students and as a reference for researchers in academia and industry. Experimental methods and instrumentation are described with topics ranging from the most widely used methods (electronic and vibrational CD) to frontier areas such as nonlinear spectroscopy and photoelectron CD, as well as the theory of chiroptical methods and techniques for simulating chiroptical properties. Applications of chiroptical spectroscopy to problems in organic stereochemistry, inorganic stereochemistry, and biochemistry and structural biology are also discussed, and each chapter is written by one or more leading authorities with extensive experience in the field.

Author Biography

Nina Berova is a Research Professor in the Department of Chemistry at Columbia University. She has been a coeditor of the journal Chirality (Wiley) since 1998. Prasad L. Polavarapu is currently a Professor of Chemistry at Vanderbilt University. Koji Nakanishi is one of the world's leading natural products chemists and was editor of the journal, The Chemical Record (Wiley). He retired from Columbia University in 2007, but continues to conduct research. Robert W. Woody is an Emeritus Professor at Colorado State University.

Table of Contents

Preface	p. xi
Contributors	p. xiii
A Historical Overview	p. 1
The First Decades After the Discovery of CD and ORD by Aimé Cotton in 1895	p. 3
Organic Stereochemistry	p. 37
Some Inherently Chiral Chromophores-Empirical Rules and Quantum Chemical Calculations	p. 39
Electronic CD of Benzene and Other Aromatic Chromophores for Determination of Absolute Configuration	p. 73
Electronic CD Excition Chirality Method: Principles and Applications	p. 115
CD Spectra of Chiral Extended ¿-Electron Compounds: Theoretical Determination of the Absolute Stereochemistry and Experimental Verification	p. 167
Assignment of the Absolute Configurations of Natural Products by Means of Solid-State Electronic Circular Dichroism and Quantum Mechanical Calculations	p. 217
Dynamic Stereochemistry and Chiroptical Spectroscopy of Metallo-Organic Compounds	p. 251
Circular Dichroism of Dynamic Systems: Switching Molecular and Supramolecular Chirality	p. 289
Electronic Circular Dichroism of Supramolecular Systems	p. 317
The Online StereoChemical Analysis of Chiral Compounds by Hplc-Ecd Coupling in Combination with Quantum-Chemical Calculations	p. 355
Determination of the Structures of Chiral Natural Products Using Vibrational Circular Dichroism	p. 387
Determination of Molecular Absolute Configuration: Guidelines for Selecting a Suitable Chiroptical Approach	p. 421
Inorganic Stereochemistry	p. 449
Applications of Electronic Circular Dichroism to Inorganic Stereochemistry	p. 451
Biomolecules	p. 473
Electronic Circular Dichroism of Proteins	p. 475
Electronic Circular Dichroism of Peptides	p. 499
Electronic Circular Dichroism of Peptidomimetics	p. 545
Circular Dichroism Spectroscopy of Nucleic Acids	p. 575
Electronic Circular Dichroism of Peptide Nucleic Acids and Their Analogues	p. 587
Circular Dichroism of Protein-Nucleic Acid Interactions	p. 615
Drug and Natural Product Binding to Nucleic Acids Analyzed by Electric Circular Dichroism	p. 635
Probing HSA and AGP Drug-Binding Sites by Electronic Circular Dichroism	p. 665
Conformational Studies of Biopolymers, Peptides, Proteins, and Nucleic Acids. A Role for Vibrational Circular Dichroism	p. 707
Structure and Behavior of Biomolecules from Raman Optical Activity	p. 759
Optical Rotation, Electronic Circular Dichroism, and Vibrational Circular Dichroism of Carbohydrates and Glycoconjugates	p. 795
Electronic Circular Dichroism in Drug Discovery	p. 819
Index	p. 843
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