Introduction to Pathology | p. 1 |
Disease | p. 2 |
Inflammation | p. 2 |
Edema | p. 5 |
Ischemia and infarction | p. 5 |
Hemorrhage | p. 6 |
Alterations of cell growth | p. 7 |
Neoplasia | p. 7 |
Hereditary Diseases | p. 10 |
Disorders of immunity | p. 11 |
Acquired immunodeficiency syndrome | p. 12 |
Hepatitis | p. 13 |
Specialized Imaging Techniques | p. 16 |
Diagnostic Imaging Modalities | p. 17 |
Ultrasound | p. 18 |
Computed tomography | p. 21 |
Magnetic resonance imaging | p. 23 |
Nuclear medicine | p. 30 |
Single-photon emission computed tomography | p. 30 |
Positron emission tomography | p. 32 |
Fusion imaging | p. 34 |
Respiratory System | p. 39 |
Physiology of the Respiratory System | p. 42 |
Congenital/Hereditary Diseases | p. 42 |
Cystic fibrosis | p. 42 |
Hyaline membrane disease | p. 44 |
Inflammatory Disorders of the Upper Respiratory System | p. 44 |
Croup | p. 44 |
Epiglottitis | p. 45 |
Inflammatory Disorders of the Lower Respiratory System | p. 46 |
Pneumonia | p. 46 |
Anthrax | p. 48 |
Lung abscess | p. 48 |
Tuberculosis | p. 49 |
Pulmonary mycosis | p. 53 |
Respiratory syncytial virus | p. 55 |
Severe acute respiratory syndrome | p. 56 |
Diffuse Lung Disease | p. 56 |
Chronic obstructive pulmonary disease | p. 56 |
Pneumoconiosis | p. 61 |
Neoplasms | p. 63 |
Solitary pulmonary nodule | p. 63 |
Bronchial adenoma | p. 64 |
Bronchogenic carcinoma | p. 65 |
Pulmonary metastases | p. 68 |
Vascular Diseases | p. 69 |
Pulmonary embolism | p. 69 |
Septic embolism | p. 75 |
Pulmonary arteriovenous fistula | p. 75 |
Miscellaneous Lung Disorders | p. 77 |
Atelectasis | p. 77 |
Adult respiratory distress syndrome | p. 77 |
Intrabronchial foreign bodies | p. 78 |
Mediastinal emphysema (pneumomediastinum) | p. 79 |
Subcutaneous emphysema | p. 79 |
Disorders of the Pleura | p. 80 |
Pneumothorax | p. 80 |
Pleural effusion | p. 82 |
Empyema | p. 83 |
Mediastinal Masses | p. 84 |
Disorders of the Diaphragm | p. 86 |
Diaphragmatic paralysis | p. 87 |
Eventration of the diaphragm | p. 87 |
Other causes of elevation of the diaphragm | p. 88 |
Skeletal System | p. 97 |
Physiology of the Skeletal System | p. 92 |
Congenital/Hereditary Diseases of Bone | p. 95 |
Vertebral anomalies | p. 95 |
Spina bifida | p. 95 |
Osteopetrosis | p. 96 |
Osteogenesis imperfecta | p. 97 |
Achondroplasia | p. 99 |
Congenital hip dysplasia (dislocation) | p. 100 |
Inflammatory and Infectious Disorders | p. 102 |
Rheumatoid arthritis | p. 102 |
Osteoarthritis (degenerative joint disease) | p. 104 |
Infectious arthritis | p. 105 |
Bursitis | p. 107 |
Rotator cuff tears | p. 109 |
Tears of the menisci of the knee | p. 109 |
Bacterial osteomyelitis | p. 110 |
Tuberculous osteomyelitis | p. 114 |
Metabolic Bone Disease | p. 116 |
Osteoporosis | p. 116 |
Osteomalacia | p. 118 |
Rickets | p. 119 |
Gout | p. 120 |
Paget's disease | p. 121 |
Fibrous Dysplasia | p. 124 |
Ischemic Necrosis of Bone | p. 124 |
Benign Bone Tumors | p. 126 |
Malignant Bone Tumors | p. 131 |
Bone Metastases | p. 136 |
Fractures | p. 140 |
Types of fractures | p. 141 |
Fracture healing | p. 143 |
Pathologic fractures | p. 144 |
Stress fractures | p. 145 |
Battered-child syndrome | p. 146 |
Common fractures and dislocations | p. 147 |
Fractures and Dislocations of the Spine | p. 152 |
Herniation of Intervertebral Disks | p. 155 |
Spondylolysis and Spondylolisthesis | p. 156 |
Gastrointestinal System | p. 162 |
Physiology of the Digestive System | p. 163 |
Esophagus | p. 165 |
Tracheoesophageal fistula | p. 165 |
Esophagitis | p. 167 |
Ingestion of corrosive agents | p. 169 |
Esophageal cancer | p. 171 |
Esophageal diverticula | p. 172 |
Esophageal varices | p. 173 |
Hiatal hernia | p. 174 |
Achalasia | p. 175 |
Foreign bodies | p. 176 |
Perforation of the esophagus | p. 179 |
Stomach | p. 179 |
Gastritis | p. 179 |
Peptic ulcer disease | p. 180 |
Cancer of the stomach | p. 284 |
Lymphoma of the stomach | p. 186 |
Small Bowel | p. 287 |
Crohn's disease (regional enteritis) | p. 187 |
Small bowel obstruction | p. 188 |
Adynamic ileus | p. 190 |
Intussusception | p. 192 |
Malabsorption disorders | p. 193 |
Colon | p. 196 |
Appendicitis | p. 196 |
Diverticulosis | p. 197 |
Diverticulitis | p. 198 |
Ulcerative colitis | p. 199 |
Crohn's colitis | p. 201 |
Ischemic colitis | p. 203 |
Irritable bowel syndrome | p. 203 |
Cancer of the colon | p. 204 |
Large bowel obstruction | p. 206 |
Volvulus of the colon | p. 209 |
Hemorrhoids | p. 211 |
Gallbladder | p. 211 |
Gallstones (cholelithiasis) | p. 211 |
Acute cholecystitis | p. 212 |
Emphysematous cholecystitis | p. 214 |
Porcelain gallbladder | p. 214 |
Liver | p. 215 |
Cirrhosis of the liver | p. 215 |
Hepatocellular carcinoma | p. 216 |
Hepatic metastases | p. 217 |
Pancreas | p. 218 |
Acute pancreatitis | p. 218 |
Chronic pancreatitis | p. 220 |
Pancreatic pseudocyst | p. 222 |
Cancer of the pancreas | p. 223 |
Pneumoperitoneum | p. 225 |
Spleen | p. 227 |
Enlargement | p. 227 |
Rupture | p. 228 |
Urinary System | p. 257 |
Physiology of the Urinary System | p. 232 |
Congenital/Hereditary Diseases | p. 233 |
Anomalies of number and size | p. 233 |
Anomalies of rotation position, and fusion | p. 234 |
Anomalies of renal pelvis and ureter | p. 235 |
Ureterocele | p. 237 |
Posterior urethral valves | p. 238 |
Inflammatory Disorders | p. 239 |
Glomerulonephritis | p. 239 |
Pyelonephritis | p. 240 |
Tuberculosis | p. 242 |
Papillary necrosis | p. 242 |
Cystitis | p. 243 |
Kidney Stones | p. 244 |
Urinary Tract Obstruction | p. 248 |
Cysts and Tumors | p. 250 |
Renal cyst | p. 250 |
Polycystic kidney disease | p. 253 |
Renal carcinoma | p. 255 |
Wilms' tumor (nephroblastoma) | p. 256 |
Carcinoma of the bladder | p. 259 |
Renal Vein Thrombosis | p. 262 |
Acute Renal Failure | p. 262 |
Chronic Renal Failure | p. 263 |
Cardiovascular System | p. 266 |
Physiology of the Cardiovascular System | p. 267 |
Congenital Heart Disease | p. 269 |
Left-to-right shunts | p. 269 |
Tetralogy of Fallot | p. 272 |
Coarctation of the aorta | p. 272 |
Acquired Vascular Disease | p. 274 |
Coronary artery disease | p. 274 |
Congestive heart failure | p. 278 |
Pulmonary edema | p. 250 |
Hypertension | p. 281 |
Hypertensive heart disease | p. 283 |
Aneurysm | p. 283 |
Traumatic rupture of the aorta | p. 286 |
Dissection of the aorta | p. 287 |
Atherosclerosis | p. 289 |
Thrombosis and embolism | p. 292 |
Valvular Disease | p. 294 |
Rheumatic heart disease | p. 294 |
Mitral stenosis | p. 295 |
Mitral insufficiency | p. 297 |
Aortic stenosis | p. 297 |
Aortic insufficiency | p. 297 |
Infective endocarditis | p. 298 |
Pericardial Effusion | p. 300 |
Venous Disease | p. 302 |
Deep venous thrombosis | p. 301 |
Varicose veins | p. 304 |
Nervous System | p. 307 |
Physiology of the Nervous System | p. 308 |
Infections of the Central Nervous System | p. 311 |
Meningitis | p. 311 |
Encephalitis | p. 312 |
Brain abscess | p. 312 |
Subdural empyema | p. 313 |
Epidural empyema | p. 314 |
Osteomyelitis of the skull | p. 314 |
Tumors of the Central Nervous System | p. 316 |
Glioma | p. 317 |
Meningioma | p. 318 |
Acoustic neuroma | p. 323 |
Pituitary adenoma | p. 323 |
Craniopharyngioma | p. 325 |
Pineal tumors | p. 326 |
Chordoma | p. 327 |
Metastatic carcinoma | p. 327 |
Traumatic Processes of the Brain and Skull | p. 330 |
Skull fracture | p. 330 |
Epidural hematoma | p. 332 |
Subdural hematoma | p. 332 |
Cerebral contusion | p. 333 |
Intracerebral hematoma | p. 334 |
Subarachnoid hemorrhage | p. 334 |
Carotid artery injury | p. 335 |
Facial fractures | p. 335 |
Vascular Disease of the Central Nervous System | p. 339 |
Stroke syndrome | p. 339 |
Transient ischemic attacks | p. 341 |
Intraparenchymal hemorrhage | p. 342 |
Subarachnoid hemorrhage | p. 344 |
Multiple Sclerosis | p. 347 |
Epilepsy and Convulsive Disorders | p. 347 |
Degenerative Diseases | p. 349 |
Normal aging | p. 349 |
Alzheimer's disease | p. 349 |
Huntington's disease | p. 351 |
Parkinson's disease | p. 352 |
Cerebellar atrophy | p. 353 |
Amyotrophic lateral sclerosis (Lou Gehrig's disease) | p. 353 |
Hydrocephalus | p. 354 |
Sinusitis | p. 355 |
Hematopoietic System | p. 360 |
Physiology of the Blood | p. 361 |
Diseases of Red Blood Cells | p. 361 |
Anemia | p. 361 |
Polycythemia | p. 367 |
Diseases of White Blood Cells | p. 368 |
Leukemia | p. 368 |
Lymphoma | p. 370 |
Infectious mononucleosis | p. 373 |
Diseases of Platelets (Bleeding Disorders) | p. 374 |
Hemophilia | p. 374 |
Purpura (thrombocytopenia) | p. 376 |
Endocrine System | p. 379 |
Physiology of the Endocrine System | p. 380 |
Adrenal Glands | p. 380 |
Physiology of the adrenal glands | p. 380 |
Diseases of the adrenal cortex | p. 382 |
Diseases of the adrenal medulla | p. 386 |
Pituitary Gland | p. 390 |
Physiology of the pituitary gland | p. 390 |
Diseases of the pituitary gland | p. 391 |
Thyroid Gland | p. 394 |
Physiology of the thyroid gland | p. 394 |
Diseases of the thyroid gland | p. 394 |
Parathyroid Glands | p. 401 |
Physiology of the parathyroid glands | p. 401 |
Diseases of the parathyroid glands | p. 401 |
Diabetes Mellitus | p. 406 |
Reproductive System | p. 411 |
Infectious Diseases of Both Genders | p. 412 |
Syphilis | p. 412 |
Gonorrhea | p. 414 |
Male Reproductive System | p. 415 |
Physiology of the Male Reproductive System | p. 415 |
Benign Prostatic Hyperplasia | p. 416 |
Carcinoma of the Prostate Gland | p. 417 |
Undescended Testis (Cryptorchidism) | p. 420 |
Testicular Torsion and Epididymitis | p. 421 |
Testicular Tumors | p. 423 |
Female Reproductive System | p. 425 |
Physiology of the Female Reproductive System | p. 425 |
Pelvic Inflammatory Disease | p. 426 |
Cysts and Tumors | p. 428 |
Ovarian cysts and tumors | p. 428 |
Dermoid cyst (teratoma) | p. 429 |
Uterine fibroids | p. 431 |
Endometrial carcinoma | p. 433 |
Endometriosis | p. 434 |
Carcinoma of the cervix | p. 435 |
Breast Lesions | p. 438 |
Breast Cancer | p. 438 |
Benign breast disease | p. 444 |
Imaging in Pregnancy | p. 445 |
Ectopic pregnancy | p. 447 |
Trophoblastic disease | p. 447 |
Female infertility | p. 448 |
Miscellaneous Diseases | p. 452 |
Nutritional Diseases | p. 453 |
Vitamin deficiencies | p. 453 |
Hypervitaminosis | p. 456 |
Protein-calorie malnutrition (kwashiorkor) | p. 456 |
Obesity | p. 456 |
Lead Poisoning | p. 457 |
Sarcoidosis | p. 459 |
Systemic Lupus Erythematosus | p. 461 |
Melanoma | p. 462 |
Muscular Dystrophy | p. 463 |
Hereditary Diseases | p. 464 |
Chromosomal aberrations | p. 464 |
Genetic amino acid disorders | p. 467 |
Internal Devices | p. 470 |
Endotracheal tube | p. 470 |
Central venous catheters | p. 470 |
Swan-Ganz catheters | p. 471 |
Transvenous cardiac pacemakers | p. 472 |
Answers to Review Questions | p. 475 |
Illustration Credits | p. 478 |
Prefixes/Suffixes/Roots | p. 482 |
Laboratory Values and their Significance | p. 484 |
Glossary | p. 485 |
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