Computation in Cells and Tissues

by Bolouri, Hamid; Paton, Ray; Holcombe, W. Michael L.; Parish, J. Howard; Tateson, Richard

• ISBN13: 9783540003588
• ISBN10: 3540003584
• Format: Hardcover
• Copyright: 2004-08-30
• Publisher: Springer-Verlag New York Inc

Summary

This book deals with key issues in the emerging interdisciplinary area involving cellular systems, computational modelling, and biologically inspired computing. This highly multidisciplinary book offers a unique blend of topical contributions that are written by biologists, computer scientists and mathematicians with non-expert readers in mind. It reflects important trends and developments in this exciting field of science. The volume can serve as a textbook and reference book for advanced students and computer scientists, biologists, and mathematicians. TOC:Introduction.- Emerging CytoComputational Metaphors.- Macromolecular Structures, Functions, and Networks.- Hierarchies and Integration.- Index.

Author Biography

Ray Paton trained originally as a biologist and for the last 12 years has worked in Computer Science. He is currently a Senior Lecturer in Dept Computer Science, University of Liverpool. He was the director of the CytoCom project on which this book is based. Hamid Bolouri, PhD Microelectronics , Brunel Univ. 1990 Currently Professor of Computational Biology, Inst. for Systems Biology , Seattle, WA98103Mike Holcombe is a Professor of Computer Science, University of Sheffield.Howard Parish is a Senior Lecturer in the Biochemistry.Richard Tateson has worked on nature-inspired computation at BTexact since 1997, applying ideas from cell biology, developmental biology and evolution to problems in telecommunications. Prior to that he was at Cambridge University doing a BA in biochemistry and a PhD in developmental biology.

Table of Contents

CytoComputational systems - perspectives and tools of thought	p. 1
Cells in telecommunications	p. 9
Symbiogenesis as a machine learning mechanism	p. 27
An overview of artificial immune systems	p. 51
Embryonics and immunotronics : biologically inspired computer science systems	p. 93
Biomedical applications of micro and nano technologies	p. 117
Macromolecules, genomes and ourselves	p. 125
Models of genetic regulatory networks	p. 149
A model of bacterial adaptability based on multiple scales of interaction : COSMIC	p. 161
Stochastic computations in neurons and neural networks	p. 185
Spatial patterning in explicitly cellular environments : activity-regulated juxtacrine signalling	p. 211
Modelling the GH release system	p. 227
Hierarchies of machines	p. 251
Models of recombination in ciliates	p. 269
Developing algebraic models of protein signalling agents	p. 277
Categorical language and hierarchical models for cell systems	p. 289
Mathematical systems biology : genomic cybernetics	p. 305
What kinds of natural processes can be regarded as computations?	p. 327
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