Concepts In Clinical Pharmacokinetics

by DiPiro, Joseph T.

• ISBN13: 9781585281244
• ISBN10: 1585281247
• Edition: 4th
• Format: Paperback
• Copyright: 2005-10-30
• Publisher: Amer Soc of Health System

Table of Contents

Acknowledgments	vii
Preface to the Third Edition	ix
Preface to the Fourth Edition	xi
Abbreviations	xiii
Pharmacy Continuing Education Program	xv
Lessons and Practice Sets
Introduction to Pharmacokinetics and Pharmacodynamics	1	(18)
Basic Pharmacokinetics	19	(10)
Half-Life, Elimination Rate, and AUC	29	(14)
Practice Set 1	43	(40)
Intravenous Bolus Administration, Multiple Drug Administration, and Steady-State Average Concentrations	45	(14)
Relationships of Pharmacokinetic Parameters and Intravenous Intermittent and Continuous Infusions	59	(14)
Two-Compartment Models	73	(10)
Practice Set 2	83	(70)
Biopharmaceutics: Absorption	87	(14)
Drug Distribution and Protein Binding	101	(10)
Drug Elimination Processes	111	(18)
Nonlinear Processes	129	(10)
Pharmacokinetic Variation and Model-Independent Relationships	139	(14)
Practice Set 3	153	(50)
Aminoglycosides	157	(16)
Vancomycin	173	(14)
Theophylline	187	(6)
Phenytoin and Digoxin	193	(10)
Appendix A. Basic and Drug-Specific Pharmacokinetic Equations	203	(8)
Appendix B. Supplemental Problems	211	(6)
Appendix C. Glossary	217	(2)
Index	219