Congenital Malformations of the Brain Pathological, Embryological, Clinical, Radiological, and Genetic Aspects

by Norman, Margaret G.; McGillivray, Barbara C.; Kalousek, Dagmar K.; Hill, Alan; Poskitt, Kenneth J.; Becker, Laurence E.; Cochrane, D. Douglas; Muenke, Maximillian

• ISBN13: 9780195062458
• ISBN10: 0195062450
• Format: Hardcover
• Copyright: 1995-06-01
• Publisher: Oxford University Press

Summary

Offering a new and uniquely multidisciplinary approach to malformations of the brain, this book begins with definitions that clarify the different types of malformations. Since malformations occur in a forming brain, neuroembryology and some of the genes guiding normal development are discussed. Causes of malformations--abnormal chromosomes, Mendelian genetics and external teratogens-- are reviewed. After this basic knowledge has been put in place, each "user-friendly" chapter synthesizes the neuropathology, specific embryology related to the pathology to the malformation, and what is known of possible causes and mechanisms by which the malformation occurs. Each chapter also describes the clinical, radiological, chromosomal and genetic aspects of the malformation. The central nervous system in twins and arthrogryposis multiplex congenita is also considered. Generously illustrated, this volume contains instructive pictures of fetal malformations. The chapter on migration disorders contains many gross and microscopic photographs. Destructive lesions, perinatal hemorrhagic and hypoxic-ischemic lesions and early neonatal degenerations are considered in order to differentiate them from malformations. The book concludes with an appendix listing gene loci which have so far been identified for various malformations.

Table of Contents

Introduction

Embryology of the Central Nervous System

Causes of Malformations

Neural Tube Defect: I, General Introduction

Neural Tube Defect: II, Anencephaly and Others

Neural Tube Defect: III, Chiari II Malformation

Neural Tube Defect: IV, Malformations Associated with Neural Tube Defect

Abnormalities of the Cerebral Hemisphere--Introduction

Holoprosencephaly: Defects of the Mediobasal Prosencephalon

Migration Disorders and Cortical Dysplasias of the Cerebrum: I, MigrationDisorders

Migration Disorders and Cortical Dysplasias: II, Cortical Dysplasias andEctomesodermal Syndromes

Crossing the Midline

Hydrocephalus

Malformations of the Brainstem and Cerebellum

Malformations of the Skull, Meninges, Choroid Plexus and Blood Vessels

Hamartomas

Miscellaneous

Prenatal Destructive Lesions

Perinatal Acquired Lesions

Perinatal Degenerative Lesions

Pathological Techniques

Appendix: Malformations for Which Specific Genes Have Been Identified

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