Conjugation-Deconjugation Reactions in Drug Metabolism and Toxicity

by Kauffman, Frederick C.; Bock, K. W.

• ISBN13: 9780387571225
• ISBN10: 0387571221
• Format: Hardcover
• Copyright: 1994-05-01
• Publisher: Springer Nature

Summary

Rutgers University, Piscataway, New Jersey. Handbook of Experimental Pharmacology, Volume 112. Advanced research from 30 leading investigators, including 23 U.S. contributors.

Table of Contents

The Uridine Diphosphate Glucuronosyltransferase Multigene Family: Function and Regulation	p. 3
Sulfotransferase Enzymes	p. 45
Regulation of Expression of Rat Liver Glutathione S-Transferases: Xenobiotic and Antioxidant Induction of the Ya Subunit Gene	p. 79
Human N-Acetyltransferases	p. 109
Genetic Regulation of the Subcellular Localization and Expression of Glucuronidase	p. 131
Microsomal Amidases and Carboxylesterases	p. 161
O-, N-, and S-Methyltransferases	p. 189
Cofactor Supply as a Rate-Limiting Determinant of Hepatic Conjugation Reactions	p. 219
Regulation of Drug Conjugate Production by Futile Cycling in Intact Cells	p. 245
Pharmacokinetic Modeling of Drug Conjugates	p. 257
Regulation of Drug Conjugate Processing by Hepatocellular Transport Systems	p. 311
Biologically Active Conjugates of Drugs and Toxic Chemicals	p. 341
Acyl Glucuronides as Chemically Reactive Intermediates	p. 367
Roles of Uridine Diphosphate Glucuronosyltransferases in Chemical Carcinogenesis	p. 391
Sulfonation in Chemical Carcinogenesis	p. 429
Glutathione Conjugate-Mediated Toxicities	p. 459
Challenges and Directions for Future Research	p. 511
Subject Index	p. 525
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