Coumarins Biology, Applications and Mode of Action

by O'Kennedy, Richard; Thornes, R. Douglas

• ISBN13: 9780471969976
• ISBN10: 0471969974
• Edition: 1st
• Format: Hardcover
• Copyright: 1997-04-21
• Publisher: Wiley
• More Book Details
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Summary

Coumarins: Biology, Applications and Mode of Action predominantly focuses on the parent compound, coumarin, and its main metabolite in humans, 7-hydroxycoumarin. It describes in detail every facet of these compounds including history, toxicology, chemistry, metabolism, analysis, clinical, veterinary and other applications, their roles as immunomodulatory agents and speculates on their mode of action.

Author Biography

Richard O'Kennedy is the editor of Coumarins: Biology, Applications and Mode of Action, published by Wiley.

R. Douglas Thornes is the editor of Coumarins: Biology, Applications and Mode of Action, published by Wiley.

Table of Contents

List of Contributors	vii	(2)
Preface	ix
1. History of the Development and Applications of Coumarin and Coumarin-related Compounds	22	(1)
Inge Weinmann
2. The Chemistry and Occurrence of Coumarins	23	(44)
Gary J. Keating
Richard O'Kennedy
3. The Metabolism of Coumarin	67	(26)
Olavi Pelkonen
Hannu Raunio
Arja Rautio
Markku Pasanen
Matti A. Lang
4. The Effects of Coumarin and its Metabolites on Cell Growth and Development	93	(10)
Barbara Seliger
5. Coumarin as an Immunomodulator	103	(22)
Gerhard J. Zlabinger
6. The Mode of Entry of Coumarin into Cells and its Effects on Cell-Cell Communication and Migration	125	(18)
Kurt S. Zanker
7. Coumarin in the Treatment of Lymphoedema and Other High-Protein Oedemas	143	(42)
John R. Casley-Smith
Judith R. Casley-Smith
8. Mode of Action of Coumarin in the Treatment of Thermal Injuries	185	(24)
Neil B. Piller
9. Renal Cell Carcinoma: The Background, Rationale and Current Development of Coumarin (1,2-benzopyrone) as a Potential Therapeutic Agent	209	(32)
Scot W. Ebbinghaus
James L. Mohler
M. Ernest Marshall
10. The Potential Role of Coumarins in the Therapy of Prostate Cancer	241	(14)
James L. Mohler
Bernadette T. Williams
John A. Freeman
M. Ernest Marshall
11. Clinical and Biological Observations Associated with Coumarins	255	(12)
R.D. Thornes
12. Analysis of Coumarins	267	(36)
Declan P. Bogan
Gary J. Keating
Heiko Reinartz
Ciaran F. Duffy
Malcolm R. Smyth
Richard Kennedy
13. Coumarins--Multifaceted Molecules with Many Analytical and Other Applications	303	(30)
Deirdre Cooke
Brian Fitzpatrick
Richard O'Kennedy
Teresa McCormack
Denise Egan
14. Suggested Modes of Action of Coumarins and Some Comments on their Significance	333	(4)
Richard O'Kennedy
R.D. Thornes
Index	337