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9781621822172

A Cure Within Scientists Unleashing The Immune System to Kill Cancer

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  • ISBN13:

    9781621822172

  • ISBN10:

    1621822176

  • Format: Hardcover
  • Copyright: 2017-10-01
  • Publisher: Cold Spring Harbor Laboratory Press

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Summary

Includes interviews with 2018 Nobel Prize Winners James Allison and Tasuku Honjo

The way we treat cancer is about to change forever. This revolution--and it is precisely that--was sparked not by the invention of a new drug, but by the evolution of an entirely new way of thinking about and managing cancer. Going forward, doctors will not use pharmaceuticals to attack tumors--not directly. Rather, the oncologist will treat the patient's immune system with a drug, and then the patient will treat the tumor.

Based entirely on interviews with the investigators, this book is the story of the immuno-oncology pioneers. It's a story of failure, resurrection, and success. It's a story about science, it's a story about discovery, and intuition, and cunning. It's a peek into the lives and thoughts of some of the most gifted medical scientists on the planet.

This is not a textbook. This is a life book. This technology will save/is saving lives, and the book celebrates the living, breathing, thinking, charming, arrogant, funny, obstinate, amazing human beings who are making immuno-oncology happen.

"The stories and lives shared in this book show readers the decades of devotion and passion it takes to imagine a better world and then make it happen. If this book motivates even one more similarly talented and visionary investigator to deliver on their promise it would be a wonderful success." -- Clifford A. Hudis, MD, FACP, FASCO
Chief Executive Officer, American Society of Clinical Oncology

Author Biography


Neil Canavan is a veteran journalist specializing in science and medicine, a career he embarked upon after earning a master's degree in molecular and cellular biodynamics from Rutgers University. With over 15 years of reporting experience, and some 200 feature articles to his credit Neil has written for such news outlets as WebMD, Medscape, Drug Discovery and Development Magazine, and The Scientist. Currently, Neil is a contributing editor to The Oncology Business Review where he has written many articles on the technology of, and clinical outcomes for cancer immunotherapy.

For the last two years Neil has held the position of Scientific Advisor at The Trout Group, a New York-based investor relations firm focused on healthcare biotechnology. The Trout Group has 30 clients in the oncology space, with many of those companies pursuing the development of cancer immunotherapies. With the aim of informing and educating the general publicand thereby all the stakeholders in the setting of clinical oncologyThe Trout Group is sponsoring the writing of this book.

Table of Contents


Section/Chapter/Investigator

Section I: CTLA-4

Chapter one: James Allison, M.D. Anderson Cancer Center

Chapter two: Jedd Wolchok, Memorial Sloan Kettering Cancer Center

Chapter three: Axel Hoos, GlaxoSmithKline

Section II: PD-1

Chapter four: Tasuku Honjo, Kyoto University

Chapter five: Gordon Freeman, Dana Farber Cancer Center

Chapter six: Suzanne Topalian, Johns Hopkins University

Section III: CARs

Chapter seven: Zelig Eshhar, Weizmann Institute

Chapter eight: Patrick Hwu, M.D. Anderson Cancer Center

Chapter nine: Michel Sadelain, Memorial Sloan Kettering Cancer Center

Chapter ten: Carl June, University of Pennsylvania

Section IV: Immuno-editing

Chapter eleven: Robert Schreiber, Washington University in St Louis

Section V: Vaccines

Chapter twelve: Elizabeth Jaffee, Johns Hopkins University

Chapter thirteen: Drew Pardoll, Johns Hopkins University

Section VI: Oncolytics

Chapter fourteen: Robert Coffin, Replimune

Section VII: Bispecifics

Chapter fifteen: Patrick Baeuerle, MPM Capital (formerly of Micromet)

Section VIII: MDSCs

Chapter sixteen: Dimitri Gabrilovich, Wistar Institute

Chapter seventeen: Vincenzo Bronte, University of Verona

Section IX: IDO

Chapter eighteen: David Munn, Georgia Regents University

Section X: STING

Chapter nineteen: Tom Gajewski, University of Chicago

Section XI: Microbiome

Chapter twenty: Laurence Zitvogel, Gustave Roussy

Section XII: Dendritic cells

Chapter twenty-one: Ralph Steinman, in memoriam (Note: Dr. Steinman is the only investigator highlighted posthumously. The reasons for this are explained within the chapter.)

Epilogue: Hope or Hype?

Cartoon Gallery

Glossary

Supplemental Materials

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