- Authors
- Preface
- Milestone 25th Silver Anniversary Edition
- 1. Advancing the Quality & Safety of Care
- Introduction
- Current Context
- Strategies & Models for Quality Improvement (QI)
- Principles of Patient Safety (Incident Reporting, Just Culture, Disclosure, FMEA, RCA, Reliability, Data, & Checklists)
- 2. The Newborn Infant
- Introduction
- The Neonatal History
- Assessment of Growth & Gestational Age
- Examination at Birth
- Examination in the Nursery
- Care of the Well Neonate
- Common Problems in the Term Newborn
- Neonatal Intensive Care
- Cardiac Problems in the Newborn Infant
- Gastrointestinal & Abdominal Surgical Conditions in the Newborn Infant
- Infections in the Newborn Infant
- Hematologic Disorders in the Newborn Infant
- Renal Disorders in the Newborn Infant
- Neurologic Problems in the Newborn Infant
- Metabolic Disorders in the Newborn Infant
- Quality Assessment & Improvement in the Newborn Nursery & NICU
- 3. Child Development & Behavior
- Introduction
- Normal Development
- Behavioral & Developmental Variations
- Enuresis & Encopresis
- Common Developmental Concerns
- Well-Child Surveillance & Screening
- 4. Adolescence
- Introduction
- Epidemiology
- Providing A Medical Home for Adolescents
- Relating to the Adolescent Patient
- Guidelines for Adolescent Preventive Services
- Growth & Development
- Adolescent Gynecology & Reproductive Health
- 5. Adolescent Substance Abuse
- Scope of the Problem
- Morbidity Data
- Predicting the Progression From Use to Abuse
- Evaluation of Substance Abuse
- Treatment & Referral
- Prevention
- References
- 6. Eating Disorders
- Introduction
- Etiology
- Incidence
- Predisposing Factors & Clinical Profiles
- Anorexia Nervosa
- Bulimia Nervosa
- Binge-Eating Disorder
- Avoidant/Restrictive Food Intake Disorder
- Prognosis, Quality Assessment, & Outcomes Metrics
- Resources for Practitioners & Families
- 7. Child & Adolescent Psychiatric Disorders & Psychosocial Aspects of Pediatrics
- Introduction
- Models of Care Encompassing Behavioral Health in the Primary Care Setting
- Prevention, Early Identification, & Developmental Context
- Lifestyle Recommendations
- Identification & Assessment During Health Supervision Visits
- Tools for Mental Health Screening in the Primary Care Office Setting
- Psychiatric Disorders of Childhood & Adolescence
- Obsessive-Compulsive & Related Disorders
- Attention-Deficit/Hyperactivity Disorder
- Mood Disorders
- Suicide in Children & Adolescents
- Disruptive, Impulse-Control, & Conduct Disorders
- High-Risk Patients & Homicide
- Somatic Symptom & Related Disorders
- Adjustment Disorders
- Psychotic Disorders
- Other Psychiatric Conditions
- References
- 8. Child Abuse & Neglect
- Introduction
- Prevention
- Clinical Findings
- Differential Diagnosis
- Treatment
- Prognosis
- 9. Ambulatory & Office Pediatrics
- Introduction
- Pediatric History
- Pediatric Physical Examination
- Health Supervision Visits
- Mental & Behavioral Health
- Telephone Management & Web-Based Information
- Advocacy & Community Pediatrics
- Toxic Stress
- Common General Pediatric Issues
- 10. Immunization
- Standards for Pediatric Immunization Practices
- Routine Childhood & Adolescent Immunization Schedules
- Vaccinations for Special Situations
- 11. Normal Childhood Nutrition & Its Disorders
- Nutritional Requirements
- Infant Feeding
- Nutrition for Children 2 Years & Older
- Nutrition Support
- 12. Emergencies & Injuries
- Introduction to Pediatric Emergencies & Injuries
- Approach to the Pediatric Trauma Patient
- Head Injury
- Burns
- Disorders Due to Extremes of Environment
- Submersion Injuries
- Lacerations
- Animal & Human Bites
- Pain Management & Procedural Sedation
- 13. Poisoning
- Introduction
- Pharmacologic Principles of Toxicology
- Preventing Childhood Poisonings
- General Treatment of Poisoning
- Management of Specific Common Poisonings
- Acetaminophen (Paracetamol)
- Alcohol, Ethyl (Ethanol)
- Amphetamines & Related Drugs (Stimulants, Methamphetamine, 3,4-Methylenedioxy-N-Methylamphetamine)
- Anesthetics, Local
- Antihistamines & Cough & Cold Preparations
- Barbiturates & Benzodiazepines
- Belladonna Alkaloids (Atropine, Jimsonweed, Potato Leaves, Scopolamine, Stramonium)
- ß-Blockers & Calcium Channel Blockers
- Carbon Monoxide
- Caustics
- Central a2-Adrenergic Agonist
- Cocaine
- Cosmetics & Related Products
- Cyclic Antidepressants
- Digitalis & Other Cardiac Glycosides
- Diphenoxylate with Atropine (Lomotil) & Loperamide (Imodium)
- Disinfectants & Deodorizers
- Disk-Shaped “Button” Batteries
- Ethylene Glycol & Methanol
- ?-Hydroxybutyrate, ?-Butyrolactone, Butanediol, Flunitrazepam, & Ketamine
- Hydrocarbons (Benzene, Charcoal Lighter Fluid, Gasoline, Kerosene, Petroleum Distillates, Turpentine)
- Ibuprofen
- Insect Stings (Bee, Wasp, & Hornet)
- Insecticides
- Iron
- Lead
- Magnets
- Marijuana
- Mushrooms
- Nitrites, Nitrates, Aniline, Pentachlorophenol, & Dinitrophenol
- Opioids & Opiates
- Oral Anti-Diabetics (Sulfonylureas, Metformin)
- Antipsychotics (Typical & Atypical)
- Plants
- Psychotropic Drugs
- Salicylates
- Scorpion Stings
- Serotonin Reuptake Inhibitors
- Snakebite
- Soaps & Detergents
- Spider Bites
- Vitamins
- Warfarin (Coumadin) & Newer Oral Anticoagulants (NOAC)
- 14. Critical Care
- Introduction
- Respiratory Critical Care
- Major Respiratory Diseases in the Pediatric ICU
- Cardiovascular Critical Care
- Neurocritical Care
- Acute Kidney Injury & Renal Replacement Therapy
- Fluid Management & Nutritional Support of the Critically Ill Child
- Sedation & Analgesia in the Pediatric ICU
- End-of-Life Care & Death in the PICU
- Quality Improvement Initiatives in the PICU
- 15. Skin
- General Principles
- Disorders of the Skin in Newborns
- Common Skin Diseases in Infants, Children, & Adolescents
- 16. Eye
- Introduction
- Common Nonspecific Signs & Symptoms
- Refractive Errors
- Ophthalmic Examination
- Ocular Trauma
- Disorders of the Ocular Structures
- Disorders of the Nasolacrimal System
- Diseases of the Conjunctiva
- Disorders of the Iris
- Glaucoma
- Uveitis
- Disorders of the Cornea
- Disorders of the Lens
- Disorders of the Retina
- Diseases of the Optic Nerve
- Diseases of the Orbit
- Esotropia (Crossed Eyes)
- Exotropia (Wall-Eyed, Drifting of Eyes)
- 17. Oral Medicine & Dentistry
- Pediatric Oral Health
- Oral Examination of Children
- Dental Caries
- Periodontal Disease
- Dental Emergencies
- Special Patient Populations
- Orthodontic Referral
- 18. Ear, Nose, & Throat
- The Ear
- The Nose & Paranasal Sinuses
- The Throat & Oral Cavity
- 19. Respiratory Tract & Mediastinum
- Respiratory Tract
- Growth & Development
- Diagnostic Aids
- General Therapy for Pediatric Lung Diseases
- Disorders of the Conducting Airways
- Laryngomalacia & Congenital Disorders of the Extrathoracic Airway
- Acquired Disorders of the Extrathoracic Airway
- Congenital Causes of Intrathoracic Airway Obstruction
- Acquired Causes of Intrathoracic Airway Obstruction
- Disorders of Mucociliary Clearance
- Congenital Malformations of the Lung Parenchyma
- Acquired Abnormalities of the Lung Parenchyma
- Atypical Pneumonias
- Bronchiolitis Obliterans
- Diseases of the Pulmonary Circulation
- Disorders of the Chest Wall
- Neuromuscular Disorders & Lung Disease
- Disorders of the Pleura & Pleural Cavity
- Mediastinum
- Sleep-Disordered Breathing
- Primary Snoring & Obstructive Sleep Apnea
- Periodic Breathing & Central Sleep Apnea
- Brief Resolved Unexplained Events (Formerly Apparent Life-Threatening Events)
- 20. Cardiovascular Diseases
- Introduction
- Diagnostic Evaluation
- Perinatal & Neonatal Circulation
- Heart Failure
- Genetic Basis of Congenital Heart Disease
- Acyanotic Congenital Heart Disease
- Cyanotic Congenital Heart Disease
- Quality Improvement in Congenital Heart Disease
- Acquired Heart Disease
- Preventive Cardiology
- Chest Pain
- Cardiac Transplantation
- Quality Improvement for Pediatric Heart Transplantation
- Pulmonary Hypertension
- Disorders of Rate & Rhythm
- Syncope (Fainting)
- 21. Gastrointestinal Tract
- Disorders of the Esophagus
- Disorders of the Stomach & Duodenum
- Disorders of the Small Intestine
- Disorders of the Colon
- Disorders of the Peritoneal Cavity
- Gastrointestinal Tumors & Malignancies
- Major Gastrointestinal Symptoms & Signs
- 22. Liver & Pancreas
- Liver Disorders
- Pancreatic Disorders
- 23. Fluid, Electrolyte, & Acid–Base Disorders & Therapy
- Regulation of Body Fluids, Electrolytes, & Tonicity
- Acid–Base Balance
- Fluid & Electrolyte Management
- Acid–Base Disturbances
- 24. Kidney & Urinary Tract
- Evaluation of the Kidney & Urinary Tract
- Congenital Anomalies of the Urinary Tract
- Hematuria & Glomerular Disease
- Tubulointerstitial Disease
- Proteinuria & Renal Disease
- Diseases of the Renal Vessels
- Renal Failure
- Hypertension
- Inherited or Developmental Defects of the Kidneys
- Urinary Tract Infections
- QA/QI in Pediatric Nephrology
- 25. Neurologic & Muscular Disorders
- Neurologic Assessment & Neurodiagnostics
- Disorders Affecting the Nervous System in Infants & Children
- Ataxias of Childhood
- Infections & Inflammatory Disorders of the Central Nervous System
- Syndromes Presenting as Acute Flaccid Weakness
- Motor Neuron Disorders
- Miscellaneous Neuromuscular Disorders
- 26. Orthopedics
- Introduction
- Disturbances of Prenatal Origin
- Deformities of the Extremities
- Common Spine Conditions
- Inflammatory Conditions
- Syndromes with Musculoskeletal Involvement
- Neurologic Disorders Involving the Musculoskeletal System
- Trauma
- Fractures
- Infections of the Bones & Joints
- Vascular Lesions & Avascular Necrosis (Osteochondroses)
- Neoplasia of the Musculoskeletal System
- Miscellaneous Diseases of Bone & Joint
- Quality Assurance/Improvement Initiatives in Orthopedics
- 27. Sports Medicine
- Basic Principles
- Common Sports Medicine Issues & Injuries
- Prevention
- 28. Rehabilitation Medicine
- Pediatric Brain Injury
- Spinal Cord Injury
- Brachial Plexus Lesions & Typical Features
- Common Rehabilitation Problems
- Quality Assurance/Improvement Initiatives in Rehabilitation Medicine
- 29. Rheumatic Diseases
- Juvenile Idiopathic Arthritis
- Systemic Lupus Erythematosus
- Dermatomyositis
- Vasculitis
- Raynaud Phenomenon
- Noninflammatory Pain Syndromes
- 30. Hematologic Disorders
- Normal Hematologic Values
- Bone Marrow Failure
- Constitutional Aplastic Anemia (Fanconi Anemia)
- Acquired Aplastic Anemia
- Anemias
- Polycythemia & Methemoglobinemia
- Disorders of Leukocytes
- Splenic Abnormalities
- Transfusion Medicine
- 31. Neoplastic Disease
- Major Pediatric Neoplastic Diseases
- Blood & Marrow Transplant & Cellular Therapeutics
- Late Effects of Pediatric Cancer Therapy
- 32. Pain Management & Pediatric Palliative & End-of-Life Care
- Introduction
- Pain Assessment
- Acute Pain
- Chronic Pain Management
- Pediatric Palliative & End-of-Life Care
- 33. Immunodeficiency
- Introduction
- Immunodeficiency Evaluation: Primary Considerations
- Severe Combined Immunodeficiency Diseases
- SCID Classification
- Other Combined Immunodeficiencies
- Antibody Deficiency Syndromes
- Phagocyte Disorders
- Deficiencies of the Innate Immune System
- Immunodeficiency Diseases That Present with Autoimmunity
- Immunodeficiency Diseases That Overlap with Allergy
- 34. Endocrine Disorders
- General Concepts
- Disturbances of Growth
- Disorders of the Posterior Pituitary Gland
- Thyroid Gland
- Disorders of Calcium & Phosphorus Metabolism
- Gonads (Ovaries & Testes)
- Abnormalities in Female Pubertal Development & Ovarian Function
- Polycystic Ovarian Syndrome
- Abnormalities in Male Pubertal Development & Testicular Function
- Adrenal Cortex
- 35. Diabetes Mellitus
- Quality Assessment & Outcomes Metrics
- Associated Autoimmune Diseases in Type 1 Diabetes
- Associated Conditions with Type 2 Diabetes
- References
- 36. Inborn Errors of Metabolism
- Introduction
- Diagnosis
- Management of Metabolic Emergencies
- Newborn Screening
- Disorders of Carbohydrate Metabolism
- Disorders of Energy Metabolism
- Disorders of Amino Acid Metabolism
- Organic Acidemias
- Disorders of Fatty Acid Oxidation & Carnitine
- Purine Metabolism Disorders
- Lysosomal Diseases
- Peroxisomal Diseases
- Congenital Disorders of Glycosylation
- Smith-Lemli-Opitz Syndrome & Disorders of Cholesterol Synthesis
- Disorders of Brain Specific Metabolism: Neurotransmitters, Synthesis of Amino Acids & Glucose Transport
- Creatine Synthesis Disorders
- Quality Initiatives in the Field of Metabolic Disease
- 37. Genetics & Dysmorphology
- Foundations of Genetic Diagnosis
- Principles of Inherited Human Disorders
- Dysmorphology & Human Embryology
- Chromosomal Disorders: Abnormal Number
- Chromosomal Abnormalities: Abnormal Structure
- Chromosome Deletion Disorders
- Contiguous Gene Disorders
- Mendelian Disorders
- Nonmendelian Disorders
- Disorders of Multifactorial Inheritance
- Common Recognizable Disorders with Variable or Unknown Cause
- Genetic Evaluation of the Child with Developmental Disabilities
- Perinatal Genetics
- 38. Allergic Disorders
- Introduction
- Asthma
- Allergic Rhinoconjunctivitis
- Atopic Dermatitis
- Urticaria & Angioedema
- Anaphylaxis
- Adverse Reactions to Drugs & Biologicals
- Food Allergy
- Insect Allergy
- 39. Antimicrobial Therapy
- Principles of Antimicrobial Therapy
- Concepts for Judicious Use of Antimicrobials
- Susceptibility Testing & Drug Dosing Properties
- Pharmacodynamic Concepts
- Use of Antimicrobial Agents to Prevent Disease
- Choice of Antimicrobial Agents
- Specific Antimicrobial Agents
- 40. Infections: Viral & Rickettsial
- Viral Infections
- Respiratory Infections
- Infections Due to Enteroviruses & Parechoviruses
- Infections Due to Herpesviruses
- Viral Infections Spread by Insect Vectors
- Other Major Viral Childhood Exanthems
- Infections Due to Other Viruses
- Rickettsial Infections and Q Fever
- 41. Human Immunodeficiency Virus Infection
- Pathogenesis & Epidemiology
- Prevention
- Perinatally HIV-Exposed Infant
- Adolescents & Youth with HIV Exposure
- Progressive HIV Disease
- Treatment
- Quality Assurance & Outcome Metrics
- 42. Infections: Bacterial & Spirochetal
- Bacterial Infections
- Spirochetal Infections
- 43. Infections: Parasitic & Mycotic
- Parasitic Infections
- Protozoal Infections
- Metazoal Infections
- Mycotic Infections
- 44. Sexually Transmitted Infections
- Introduction
- Adolescent Sexuality
- Risk Factors
- Prevention of Sexually Transmitted Infections
- Screening for Sexually Transmitted Infections
- Signs & Symptoms
- The Most Common Antibiotic-Responsive Sexually Transmitted Infections
- The Spectrum of Signs & Symptoms of Sexually Transmitted Infections
- 45. Travel Medicine
- Introduction
- Preparing Children & Infants for Travel
- Vaccinations—Routine Childhood Vaccines Modified for Travel
- Vaccinations—Travel-Specific
- Traveler’s Diarrhea
- Malaria Prophylaxis & Prevention
- Visits to Friends & Relatives (VFR) in High-Risk Areas
- HIV & Sexually Transmitted Diseases
- Fever in the Returned Traveler
- References
- 46. Chemistry & Hematology Reference Intervals
- Challenges in Determining & Interpreting Pediatric Reference Intervals
- Guidelines for Use of Data in a Reference Range Study
- Statistical Computation of Reference Intervals
- Why Reference Intervals Vary
- Sensitivity, Specificity, & Predicitive Values
- Pediatric Reference Intervals
- Index