In keeping with the tradition of excellence of past volumes of the Current Topics in Developmental Biology series, this volume provides a comprehensive survey of major issues at the forefront of modern developmental biology and regenerative medicine. Astonishing discoveries are presented in thoughtful and forward-looking articles.

Contributors

ix

In Memorium, Professor Peter Lonai

xiii

Stepwise Commitment from Embryonic Stem to Hematopoietic and Endothelial Cells

Changwon Park

Jesse J. Lugus

Kyunghee Choi

Embryonic Stem Cell

2

(5)

From ES to Hematopoietic Progenitors

7

(17)

Conclusions and Future Directions

24

(13)

Acknowledgments

25

(1)

References

25

(12)

Fibroblast Growth Factor Signaling and the Function and Assembly of Basement Membranes

Peter Lonai

Introduction

37

(1)

Early Embryogenesis, Growth Factors, Growth Factor Receptors, and the Basement Membrane

38

(9)

Laminins and Basement Membrane-Mediated Signaling

47

(8)

Current Questions

55

(11)

References

57

(9)

TGF-β Superfamily and Mouse Craniofacial Development: Interplay of Morphogenetic Proteins and Receptor Signaling Controls Normal Formation of the Face

Marek Dudas

Vesa Kaartinen

Introduction

66

(1)

TGF-β Superfamily Signaling

67

(9)

Craniofacial Phenotypes in Mutants of TGF-β Superfamily Ligands and Receptors

76

(10)

Head Organizers and Early Anterior Development

86

(4)

Neural Crest in Early Craniofacial Development

90

(2)

Facial Prominences and Formation of the Face

92

(2)

Mandibular Development

94

(6)

Palatal Development and Cleft Palate

100

(7)

Clinical Research and Applications

107

(1)

Conclusions

108

(28)

Acknowledgments

108

(1)

References

109

(27)

The Colors of Autumn Leaves as Symptoms of Cellular Recycling and Defenses Against Environmental Stresses

Helen J. Ougham

Phillip Morris

Howard Thomas

Introduction

136

(1)

The Role of Chlorophyll in Protein Recycling

136

(5)

Non-Green Pigments in Senescing Leaves

141

(8)

Pigments and Stress Defenses in Senescing Leaves

149

(6)

Conclusions

155

(7)

Acknowledgments

155

(1)

References

156

(6)

Extracellular Proteases: Biological and Behavioral Roles in the Mammalian Central Nervous System

Yan Zhang

Kostas Pothakos

Styliana-Anna (Stella) Tsirka

Introduction

162

(1)

Plasminogen Activators

162

(8)

Plasmin(ogen)

170

(1)

Inhibitors of Plasminogen Activators and Plasmin

171

(4)

tPA Effects on Rodent Behavior

175

(4)

uPA and Plasminogen Effects on Rodent Behavior

179

(1)

Conclusions

180

(10)

Acknowledgments

180

(1)

References

180

(10)

The Genetic Architecture of House Fly Mating Behavior

Lisa M. Meffert

Kara L. Hagenbuch

Introduction

190

(2)

Evolutionary Dynamics of Quantitative Genetic Interactions

192

(3)

Courtship in the House Fly

195

(3)

Evidence of Quantitative Genetic Interactions in House Flies

198

(7)

Prevalence of Nonadditive Genetic Effects in Animal Behavior

205

(1)

Future Directions

205

(2)

Summary

207

(8)

Acknowledgments

208

(1)

References

209

(6)

Phototropins, Other Photoreceptors, and Associated Signaling: The Lead and Supporting Cast in the Control of Plant Movement Responses

Bethany B. Stone

C. Alex Esmon

Emmanuel Liscum

Introduction

215

(1)

Phototropins: The Primary Receptors in Light-Induced Plant Movement Responses

216

(3)

Cryptochromes and Phytochromes: Modulatory Receptors in Light-Induced Plant Movement Responses

219

(3)

Phototropism: Plant Movements of Entire Organs

222

(6)

Stomatal Opening: Plant Movements at the Cellular Level

228

(1)

Chloroplast Relocation: Plant Movements at the Subcellular Level

229

(2)

Conclusion

231

(9)

References

232

(8)

Evolving Concepts in Bone Tissue Engineering

Catherine M. Cowan

Chia Soo

Kang Ting

Benjamin Wu

Introduction

240

(1)

Bone Morphogenetic Proteins

241

(6)

Bone Tissue Engineering

247

(23)

Conclusions and Future Directions

270

(17)

References

272

(15)

Cranial Suture Biology

Kelly A. Lenton

Randall P. Nacamuli

Derrick C. Wan

Jill A. Helms

Michael T. Longaker

Introduction

287

(2)

Skull Vault Development

289

(3)

Craniosynostosis

292

(6)

The Murine Model of Suture Morphogenesis

298

(6)

Molecular and Cellular Mechanisms Governing Suture Morphogenesis

304

(13)

Conclusions and Perspectives

317

(12)

Acknowledgments

318

(1)

References

318

(11)

Index

329

(10)

Contents of Previous Volumes

339

What is included with this book?

The New copy of this book will include any supplemental materials advertised. Please check the title of the book to determine if it should include any access cards, study guides, lab manuals, CDs, etc.

The Used, Rental and eBook copies of this book are not guaranteed to include any supplemental materials. Typically, only the book itself is included. This is true even if the title states it includes any access cards, study guides, lab manuals, CDs, etc.