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NICHOLAS BRANDON works at AstraZeneca within the Neuroscience Innovative Medicines Group. He has spent his career in drug discovery with a strong interest in developing phosphodiesterase inhibitors for neuropsychiatric disorders and understanding the basic mechanisms of phosphodiesterase function.
ANTHONY WEST is an Associate Professor in the Department of Neuroscience at Rosalind Franklin University. He has studied PDE function in the basal ganglia for over fifteen years, focusing on neurochemical and electrophysiological changes induced by PDE inhibitors in the healthy brain and in animal models of Parkinson’s disease and Huntington’s disease.
1 Phosphodiesterases and Cyclic Nucleotide Signaling in the CNSMarco Conti and Wito Richter
2 Putting together the pieces of phosphodiesterase distribution patterns in the brain: A jigsaw puzzle of cyclic nucleotide regulationMichy P. Kelly
3 Compartmentalization and regulation of cyclic nucleotide signalling in the CNSManuela Zaccolo and Alessandra Stangherlin
4 Pharmacological manipulation of cyclic nucleotide phosphodiesterase signaling for the treatment of neurological and psychiatric disorders in the brainFrank S. Menniti, Niels Plath, Christopher J. Schmidt, and Niels Svenstrup
5 Recent results in phosphodiesterase inhibitor development and CNS applicationsDavid P. Rotella
6 Crystal structures of phosphodiesterases and implication on discovery of inhibitorsHengming Ke, Huanchen Wang, Mengchun Ye, and Yingchun Huang
7 Inhibition of cyclic nucleotide phosphodiesterases to regulate memoryHan-Ting Zhang, Ying Xu, James O’Donnell
8 Emerging role for PDE4 in neuropsychiatric disorders: Translating advances from genetic studies into relevant therapeutic strategiesSandra P. Zoubovsky, Nicholas J. Brandon P, and Akira Sawa
9 Beyond erectile dysfunction: Understanding PDE5 activity in the central nervous systemEva P. P. Bollen, Kris Rutten, Olga A. H. Reneerkens, Harry M.W Steinbusch, and Jos Prickaerts
10 Molecular and cellular understanding of PDE10A: A dual-substrate phosphodiesterase with therapeutic potential to modulate basal ganglia functionErik I. Charych and Nicholas J. Brandon
11 Role of cyclic nucleotide signaling and phosphodiesterase activation in the modulation of electrophysiological activity of central neuronsSarah Threlfell and Anthony R. West
12 The role of phosphodiesterases in dopamine systems governing motivated behaviorGretchen L. Snyder, Akinori Nishi, and Joseph P. Hendrick
13 Inhibition of phosphodiesterases as a strategy for treatment of spinal cord injuryElena Nikulina and Marie T. Filbin
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