Cytochrome P450: Structure, Mechanism, and Biochemistry

by De Montellano, Paul R. Ortiz

• ISBN13: 9781441932488
• ISBN10: 1441932488
• Edition: 2nd
• Format: Paperback
• Copyright: 2010-12-01
• Publisher: SPRINGER

Summary

The Second Edition reviews the impressive progress that has been made in the last ten years in cytochrome P450 research. Chapters emphasize structure, mechanism, biochemistry, and regulation. This edition offers expanded coverage of P450 crystal structures, site-specific mutagenesis as a probe of structure and function. New chapters explore the hormonal regulation of P450 enzymes, the cytochrome P450-catalyzed oxidation of eicosanoids, human P450 enzymes, and thiolate-ligated hemoproteins other than P450.

Table of Contents

Model Systems
Models and Mechanisms of Cytochrome P450 Action	p. 3
Comparison of the Peroxidase Activity of Hemoproteins and Cytochrome P450	p. 49
Structurally Defined Bacterial Enzymes
Twenty-five Years of P450cam Research: Mechanistic Insights into Oxygenase Catalysis	p. 83
Structural Studies on Prokaryotic Cytochromes P450	p. 125
Bacterial P450s: Structural Similarities and Functional Differences	p. 151
Structures and Mechanisms of Membrane-Bound P450 Enzymes
Structures of Eukaryotic Cytochrome P450 Enzymes	p. 183
NADPH Cytochrome P450 Reductase and Its Structural and Functional Domains	p. 225
Oxygen Activation and Reactivity	p. 245
Inhibition of Cytochrome P450 Enzymes	p. 305
Regulatory Mechanisms and Physiological Roles of Cytochrome P450
Induction of Cytochrome P450 Enzymes that Metabolize Xenobiotics	p. 367
Hormonal Regulation of Liver Cytochrome P450 Enzymes	p. 391
Regulation of Steroidogenic and Related P450s	p. 419
Cytochrome P450 and the Metabolism of Arachidonic Acid and Oxygenated Eicosanoids	p. 443
Human Cytochrome P450 Enzymes	p. 473
Heme-Thiolate Proteins Different from Cytochromes P450 Catalyzing Monooxygenations	p. 537
Appendices
Cytochrome P450 Nomenclature and Alignment of Selected Sequences	p. 575
Rat and Human Liver Cytochromes P450: Substrate and Inhibitor Specificities and Functional Markers	p. 607
Index	p. 631
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