Cytokines And Cancer

by PLATANIAS, LEONIDAS C.

• ISBN13: 9780387243603
• ISBN10: 0387243607
• Format: Hardcover
• Copyright: 2005-03-01
• Publisher: Springer Verlag

Summary

This book is a comprehensive review of the current knowledge on cytokines and cancer. Cytokines play a variety of roles in cancer, both as components of pathogenetic mechanisms, as well as agents used in the treatment of certain malignancies. To date, there has not been a book that covers both basic science and translational/clinical research in the field of cytokines in malignancies. This book is written by leading figures in the field of cytokine biology and cytokine therapeutics and is specifically focused on this subject. The book is divided into two parts. The first part is focused on current developments in the basic science field. There is a particular emphasis on novel mechanisms of cytokine actions in malignant cells. The second part deals with translational and clinical research in the field, and many of the authors of these chapters were among the first to introduce several cytokines in the treatment of certain tumors. Collectively, the information provided in this book will be helpful to people in the medical field at several levels, including medical students, interns, residents, clinical and basic science researchers, as well as oncologists in practice.

Table of Contents

Dedication	v
Contributing Authors	ix
Foreword	xiii
Basic Science Research	xv
1 Polypeptide Growth Factors and Their Receptors	1	(14)
Anupama Gururaj and Rakesh Kumar
2 Chemokines and Cancer	15	(30)
Thomas T. Murooka, Sarah E. Ward, and Eleanor N. Fish
3 Interferons	45	(26)
Simrit Parmar and Leonidas Platanias
4 Cytokines and Lymphomas	71	(34)
Georgios V. Georgakis and Anas Younes
5 Pro-apototic and Anti-apoptotic Effects of Tumor Necrosis Factor in Tumor Cells	105	(26)
Bharat B. Aggarwal and Yasunari Takada
6 Transforming Growth Factor Beta and Breast Cancer	131	(28)
Virginia Kaklamani and Boris Pasche
7 Transforming Growth Factor Beta in Prostate Cancer	159	(18)
Brian Zhu and Natasha Kyprianou
8 Angiostatin	177	(30)
Jennifer A. Doll and Gerald A. Soff
Clinical and Translational Research	207	(168)
9 Interferons in the Treatment of Solid Tumors	209	(34)
Stergios Moschos, Sai Varanasi, and John M. Kirkwood
10. Targeting Cytokine Receptors and Pathways in the Treatment of Breast Cancer	243	(20)
Ingrid A. Mayer
11. Interleukin-2 in the Treatment of Renal Cell Carcinoma and Malignant Melanoma	263	(26)
John W. Eklund and Timothy M. Kuzel
12. Cytokine Targeted Treatments for Lung Cancer	289	(24)
Jyoti Patel
13. Cytokines in the Treatment of Acute Leukemias	313	(20)
Farhad Ravandi and Partow Kebriaei
14. Cytokines in Hematopoietic Stem Cell Transplantation	333	(20)
Jayesh Mehta
15. Novel Cytokines in the Treatment of Malignancies	353	(22)
Robin Parihar and William E. Carson, III
Index	375