Data Mining in Structural Biology: Signal Transduction and Beyond

by Schlichting, I.; Egner, U.; Stock, G.; Lessl, M.

• ISBN13: 9783540414940
• ISBN10: 3540414940
• Format: Hardcover
• Copyright: 2001-07-01
• Publisher: Springer Verlag

Summary

Max Planck Institute for Molecular Physiology, Dortmund, Germany. Combines the results of investigations in molecular design, structural biology, and biochemistry, within some of the protein classes that play a major role in signal transduction. Also discusses uses of these proteins in pharmacology research.

Table of Contents

Growth Factor Regulation of Kinases	1	(18)
C.-H. Heldin
Cell Cycle Regulation by Protein Kinases and Phosphatases	19	(28)
E.A. Nigg
Structural Basis for Substrate Recognition and Control in Protein Kinases	47	(24)
L. N. Johnson
The Selectivity of Small Molecules Towards Protein Tyrosine Kinases	71	(10)
A. Levitzki
Elements of Signal Transduction in Drug Discovery with Special Reference to Inhibitors of Protein Kinase C	81	(20)
H. H. Grunicke
S. Kampger
M. Spitaler
F. Hochholdinger
G. Baier
F. Uberall
The Berlin ``Protein Structure Factory'' Initiative: A Technology-Based Approach to Structural Genomics	101	(22)
U. Heinemann
Structure-Based Approaches in Modern Drug Discovery Research	123	(20)
F. K. Winkler
D. W. Banner
H.-J. Bohm
DNA Recognition by NFkB and STAT Transcription Factors	143	(24)
C. W. Muller
Molecular Determinants for Agonists and Antagonist Binding to Steroid Nuclear Receptors	167	(14)
J.-M. Wurtz
D. Moras
Estrogen Receptor-Cofactor Interactions as Targets for Novel Drug Discovery	181	(22)
J. D. Norris
C. Chang
D. P. McDonnell
Subject Index	203	(4)
Previous Volumes Published in this Series	207