Dermatopathology: The Basics

by Smoller, Bruce R., M.D.

• ISBN13: 9781441900234
• ISBN10: 1441900233
• Edition: 1st
• Format: Paperback
• Copyright: 2009-06-01
• Publisher: SPRINGER

Summary

Dermatopathology: The Basics will serve as an effective and efficient handbook for the student of dermatopathology, and as a practical bench reference for the practicing diagnostician who desires rapid access to criteria that are useful in differentiating histologically similar entities.

Author Biography

Bruce R. Smoller, MD is Aubrey J. Hough, Jr. MD Endowed Chair of Pathology, Department Chair and Professor in Pathology and Dermatology, University of Arkansas of Medical Sciences, Little Rock, Arkansas. Kim M. Hiatt, MD is Associate Professor, Director Dermatopathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas.

Table of Contents

Normal Cutaneous Histology	p. 1
Basic Skin Anatomy	p. 1
Epidermis	p. 1
Keratinocytes	p. 1
Melanocytes	p. 5
Langerhans Cells	p. 6
Merkel Cells	p. 8
Epidermal Appendages	p. 8
Basement Membrance Zone	p. 17
Basal Keratinocyte	p. 18
Lamina Lucida	p. 18
Lamina Densa	p. 19
Sub lamina Densa	p. 19
Dermis	p. 19
Vasculature	p. 20
Nerves	p. 24
Muscles	p. 26
Subcutaneous Fat	p. 29
Skin of "Special Sites"	p. 30
How to Maximize Information from a Skin Biopsy	p. 37
Presumed Neoplastic Processes	p. 38
What is the Differential Diagnosis?	p. 38
Are the Margins Important?	p. 39
Melanocytic Neoplasms	p. 40
Keratinocytic Neoplasms	p. 41
Adnexal Neoplasms	p. 43
Dermal Neoplasms	p. 46
Hematopoietic Neoplasms	p. 49
Inflammatory Processes	p. 50
Blistering Diseases	p. 50
"Dermatitis" and "Rash"	p. 52
Infectious diseases	p. 53
Connective Tissue Diseases	p. 56
Direct Immunofluorescence	p. 57
Vasculitis	p. 57
Panniculitis	p. 58
Alopecia	p. 59
Miscellaneous Conditions	p. 60
Presumed Connective Tissue Nevus, Anetoderma, Epidermal Nevus	p. 60
Rules of Thumb	p. 61
Special Stains in Dermatopathology	p. 63
Histochemical Stains	p. 63
Commonly Used Special Stains	p. 63
Periodic Acid-Schiff (PAS)	p. 64
PAS Uses	p. 64
Alcian Blue	p. 64
Alcian Blue/Colloidal Iron Uses	p. 65
Elastic von Gieson	p. 65
Von Gieson Uses	p. 65
Brown and Brenn Stain	p. 66
Acid Fast Stain (AFB)	p. 67
Fite Stain	p. 67
Giemsa	p. 67
Giemsa Uses	p. 67
Warthin-Starry	p. 68
Masson's Trichrome	p. 69
Congo Red	p. 70
Fontana Stain For Melanin	p. 71
Chloroacetate Esterase	p. 71
Perls	p. 72
Immunopathology in Diagnostic Dermatopathology	p. 75
Tool Box: Antibody Panel	p. 75
What Is a Tool Box?	p. 75
Epithelial Markers	p. 75
Mesenchymal Markers	p. 78
Neuroectodermal Markers	p. 79
Hematopoietic Markers	p. 81
Miscellaneous Markers	p. 84
Requirements for Interpretation	p. 85
Pitfalls in Interpretation	p. 86
Strategy for Immunopathology	p. 87
Immunopathology	p. 88
Differential Diagnosis of Normal Skin	p. 93
Tinea Versicolor	p. 94
Ichthyoses	p. 96
Ichthyosis (X-Linked)	p. 96
Ichthyosis (Lamellar)	p. 97
Erythrasma	p. 98
Ichthyosis Vulgaris	p. 100
Pemphigus Foliaceus/Erythematosus	p. 101
Vitiligo	p. 102
Café-Au-Lait Macule	p. 104
Nevus Depigmentosus (Nevus Achromicus)	p. 105
Connective Tissue Nevus	p. 106
Cutis Laxa	p. 108
Morphea	p. 110
Anetoderma (Macular Atrophy, Focal Dermal Elastolysis)	p. 113
Wrinkling due to Mid-dermal Elastolysis	p. 114
Dermal Deposition Disorders	p. 114
Amyloidosis	p. 115
Localized Cutaneous Amyloidosis	p. 115
Pretibial Myxedema	p. 117
Sclerodema	p. 119
Scleromyxedema	p. 121
Nephrogenic Systemic Fibrosis	p. 122
Conditions with Minimal Inflammation	p. 124
Small Plaque (Guttate) Parapsoriasis (Digitate Dermatosis)	p. 124
Urticaria	p. 126
Urticaria Pigmentosa	p. 126
Further Reading	p. 129
Index	p. 139
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