Dermatopathology in Systemic Disease

by Smoller, Bruce R.; Horn, Thomas D.

• ISBN13: 9780195130386
• ISBN10: 0195130383
• Format: Hardcover
• Copyright: 2001-04-12
• Publisher: Oxford University Press

Summary

Dermatopathology of Systemic Disease provides extensive information on the cutaneous pathologic manifestations of systemic illnesses of all kinds. Written by a pathologist and dermatologist, the book offers an interdisciplinary perspective that suggests a series of diagnostic possibilities in the context of systemic symptoms not necessarily obvious from the cutaneous findings being evaluated. Organized by disease type (i.e. Connective tissue diseases, Metabolic and Storage Diseases, Drug-Induced Processes), the book is heavily illustrated with abundant color photomicrographs and clinical images. Clinical, histologic, and pathogenetic aspects of dermatopathology are discussed.

Table of Contents

Part I Systemic Diseases Involving the Skin and Multiple Internal Organ Systems
Lupus Erythematosus	3	(14)
Discoid Lupus Erythematosus	3	(2)
Lupus Profundus	5	(1)
Systemic Lupus Erythematosus	6	(1)
Subacute Cutaneous Lupus Erythematosus	7	(1)
Neonatal Lupus Erythematosus	8	(1)
Antiphospholipid Syndrome	9	(1)
Bullous Lupus Erythematosus	10	(1)
Livedoid Vasculitis (Atrophie Blanche)	11	(1)
Miscellaneous	12	(5)
Connective Tissue, Joint Diseases, and the Skin	17	(20)
Dermatomyositis	17	(2)
Scleroderma	19	(1)
Progressive Systemic Sclerosis	19	(2)
Morphea	21	(1)
Acral Scleroderma	21	(1)
Eosinophilic Fasciitis	22	(1)
Mixed Connective Tissue Disease	22	(2)
Sjogren's Syndrome	24	(1)
Psoriasis and Arthritis	25	(4)
Rheumatoid Arthritis	29	(2)
Gout	31	(6)
Diabetes Mellitus	37	(10)
Necrobiosis Lipoidica Diabeticorum	37	(2)
Disseminated Granuloma Annulare	39	(1)
Bullosis Diabeticorum	40	(1)
Scleredema Diabeticorum	41	(1)
Diabetic Dermopathy	42	(1)
Eruptive Xanthomata	43	(1)
Yellow Skin	43	(4)
Vasculitis	47	(14)
Small-Vessel Vasculitides	47	(1)
Leukocytoclastic Vasculitis	47	(2)
Wegener's Granulomatosis	49	(1)
Churg-Strauss Allergic Granulomatosis	50	(1)
Behcet's Disease	51	(1)
Medium-Vessel Vasculitides	52	(9)
Polyarteritis Nodosa	52	(1)
Systemic (Classic)	52	(1)
Benign Cutaneous Polyarteritis Nodosa	53	(1)
Microscopic Polyarteritis Nodosa	54	(1)
Kawasaki's Disease (Mucocutaneous Lymph Node Syndrome)	54	(7)
Part II Diseases Involving the Skin and Limited Other Organ Systems
Gastrointestinal and Hepatic Diseases	61	(12)
Intestinal Disorders and Associated Cutaneous Diseases	61	(6)
Dermatitis Herpetiformis	61	(1)
Pyoderma Gangrenosum	62	(1)
Bowel-Associated Dermatitis/Arthritis Syndrome	63	(1)
Cutaneous Crohn's Disease	64	(1)
Degos' Disease (Malignant Atrophic Papulosis)	65	(1)
Peutz-Jehgers Syndrome	66	(1)
Hepatic Diseases and Associated Cutaneous Disorders	67	(2)
Porphyrias	67	(2)
Hemochromatosis	69	(1)
Pancreatic Diseases and Associated Cutaneous Disorders	69	(4)
Pancreatic Panniculitis	69	(4)
Pulmonary and Skin Diseases	73	(10)
Sarcoidosis	73	(2)
Lymphomatoid Granulomatosis	75	(1)
α1-Antitrypsin Deficiency	76	(1)
Cystic Fibrosis-Associated Dermatosis	77	(1)
Pachydermoperiostosis	78	(1)
Yellow Nail Syndrome	78	(5)
Cardiac and Skin Diseases	83	(9)
Amyloidosis	83	(2)
Carney's Complex	85	(2)
LEOPARD Syndrome	87	(1)
Cholesterol Emboli	88	(1)
Miscellaneous Conditions	88	(4)
Renal and Skin Diseases	92	(11)
Acute Renal Diseases	92	(4)
Henoch-Schonlein Purpura	92	(2)
Hemolytic Uremic Syndrome	94	(1)
Impetigo Contagiosa with Subsequent Post-Streptococcal Glomerulonephritis	94	(2)
Chronic Renal Disease	96	(7)
Calciphylaxis	96	(1)
Reactive Perforating Disorders of Diabetes and Renal Failure	97	(1)
Pruritus of Chronic Renal Failure	98	(1)
Half-and-Half Nails	99	(1)
Post-Transplant Lymphoproliferative Disorder	99	(4)
Diseases of the Nervous System and the Skin	103	(23)
Neurofibromatosis	103	(23)
Tuberous Sclerosis	108	(2)
Refsum's Syndrome	110	(1)
Sjogren-Larsson Syndrome	110	(1)
Rud's Syndrome	111	(1)
KID Syndrome	111	(1)
Vogt-Koyanagi-Harada Syndrome	112	(1)
Rubinstein-Taybi Syndrome	113	(1)
Myotonic Dystrophy	114	(1)
Sneddon's Syndrome	115	(1)
Hypomelanosis of Ito (Incontinentia Pigmenti Achromians)	116	(1)
Incontinentia Pigmenti	117	(9)
Hematologic Malignancies and Skin Diseases	126	(29)
Lymphomas	126	(8)
Large Cell Anaplastic Lymphoma	126	(2)
Angiocentric Lymphoma	128	(1)
Subcutaneous T-Cell Lymphoma (Histiocytic Cytophagic Panniculitis)	128	(2)
Intravascular Lymphoma (Malignant Angioendotheliomatosis)	130	(1)
Secondary B-Cell Lymphoma	131	(1)
Hodgkin's Disease Involving the Skin	132	(2)
Langerhans' Cell Proliffrations	134	(3)
Histiocytosis X	134	(2)
Indeterminate Cell Disorder	136	(1)
Leukemias and the Skin	137	(2)
Primary Leukemia Cutis	137	(1)
Secondary Leukemia Cutis	138	(1)
Plasma Cell Dyscrasias and Related Cutaneous Disorders	139	(4)
Multiple Myeloma	139	(1)
Extramedullary Plasmacytoma	139	(1)
Scleromyxedema	140	(2)
Other Mucocutaneous Conditions Associated with Multiple Myeloma	142	(1)
Waldenstrom's Macroglobulinemia	142	(1)
Miscellaneous Systemic Hematopoietic Proliferations in the Skin	143	(12)
Angioimmunoblastic Lymphadenopathy	143	(1)
Sinus Histiocytosis with Massive Lymphadenopathy (Rosai-Dorfman Disease)	143	(2)
Cutaneous Eruptions of Lymphocyte Recovery	145	(10)
Musculoskeletal and Skin Diseases	155	(13)
Klippel-Trenaunay-Weber Syndrome	155	(1)
Maffucci's Syndrome and Ollier's Disease	156	(1)
Goltz's Syndrome (Focal Dermal Hypoplasia)	157	(1)
Congenital Hemidysplasia with Ichthyosiform Erythroderma and Limb Defects (CHILD) Syndrome	158	(1)
Papillon-Lefevre Syndrome	159	(1)
Epidermal Nevus Syndrome	160	(2)
Buschke-Ollendorff Syndrome	162	(1)
Ehlers-Danlos Syndrome	163	(5)
Vascular Anomalies and Skin Diseases	168	(11)
Pseudoxanthoma Elasticum	168	(2)
Fabry's Disease	170	(1)
Osler-Weber-Rendu Disease (Hereditary Hemorrhagic Telangiectasia)	171	(1)
Blue Rubber Bleb Nevus Syndrome	172	(1)
Cobb's Syndrome	173	(1)
Sturge-Weber Syndrome	174	(1)
von Hippel-Lindau Disease	175	(4)
Endocrine Abnormalities and Skin Diseases	179	(12)
Pretibial Myxedema	179	(1)
Generalized Myxedema	180	(1)
Vitiligo	181	(1)
Mucosal Neuroma Syndrome	182	(1)
Necrolytic Migratory Erythema	183	(1)
Alopecia Areata	183	(2)
Addison's Disease	185	(6)
Part III Metabolic and Storage Diseases
Storage Diseases	191	(6)
Tangier Disease	191	(1)
Niemann-Pick Disease	191	(1)
Gaucher's Disease	192	(1)
Fucosidosis	193	(1)
Farber's Lipogranulomatosis	193	(4)
Hyperlipidemias and the Skin	197	(5)
Xanthomas	197	(3)
Xanthoma Disseminatum	200	(2)
Nutritional Imbalances and the Skin	202	(7)
Phrynoderma	202	(1)
Hypervitaminosis A	202	(1)
Scurvy	203	(1)
Pellagra	203	(1)
Hartnup's Disease	204	(1)
Richner-Hanhart Syndrome (Type II Oculotyrosinosis)	204	(1)
Kwashiorkor	205	(4)
Part IV Infectious Diseases and the Skin
Bacterial Diseases	209	(21)
Direct Bacterial Infections	209	(12)
Meningococcemia	209	(1)
Septic Vasculitis/Emboli	209	(1)
Syphilis	210	(3)
Lyme Disease	213	(2)
Mycobacterial Infections-Tuberculosis	215	(2)
Mycobacterium Other than tuberculosis	217	(1)
Leprosy	218	(3)
Sequelae	221	(9)
Erythema Induratum	221	(1)
Papulonecrotic Tuberculid	222	(1)
Lichen Scrofulosorum	222	(1)
Toxic Shock Syndrome	223	(1)
Staphylococcal Scalded Skin Syndrome	224	(6)
Viral Diseases	230	(21)
Direct Infection	230	(12)
Human Papillomavirus	230	(3)
Herpes Viruses	233	(2)
Cytomegalovirus	235	(1)
Molluscum Contagiosum	236	(1)
Human Immunodeficiency Virus	237	(5)
Secondary Manifestations of Viral Infection	242	(9)
Papular Acrodermatitis of Childhood (Gianotti-Crosti Syndrome)	242	(1)
Hepatitis C	243	(8)
Fungal and Algal Diseases	251	(15)
Aspergillosis	251	(1)
Zygomycosis (Mucormycosis)	252	(1)
Cryptococcosis	253	(2)
Histoplasmosis	255	(1)
Blastomycosis (North American)	255	(2)
Coccidioidomycosis	257	(1)
Protothecosis	257	(1)
Related Hypersensitivity Reactions	258	(1)
Erythema Annulare Centrifugum	258	(1)
Id (Autosensitization Reaction) Reaction	259	(1)
Erythema Nodosum	260	(6)
Rickettsial Diseases	266	(4)
Rocky Mountain Spotted Fever	266	(1)
Ehrlichiosis	267	(1)
Rickettsialpox	268	(2)
Parasitic Infestations	270	(7)
Leishmaniasis	270	(1)
Acanthamebiasis	271	(6)
Part V Drug-Induced Processes
Drug-Induced Autoimmune Eruptions	277	(7)
Pemphigus	277	(2)
Pemphigoid	279	(2)
Linear IgA Bullous Dermatosis	281	(3)
Drug-Induced Interface Dermatoses	284	(10)
Erythema Multiforme	284	(2)
Toxic Epidermal Necrolysis	286	(2)
Fixed Drug Eruption	288	(1)
Drug-Induced Lupus Erythematosus	289	(1)
Lichenoid Drug Eruptions	290	(4)
Photo-Related Drug Eruptions	294	(4)
Phototoxic Drug Eruptions	294	(1)
Photoallergic Drug Eruptions	295	(3)
Chemotherapy-Induced Drug Eruptions	298	(6)
Neutrophilic Eccrine Hidradenitis	298	(1)
Neutrophilic Dermatosis Associated with Granulocyte-Macrophage and Granulocyte Colony-Stimulating Factor	299	(1)
Acral Erythema	300	(1)
Syringosquamous Metaplasia	301	(3)
Miscellaneous Drug Eruptions	304	(7)
Acute Generalized Exanthematous Pustulosis	304	(1)
Drug-Induced Pseudolymphomas	305	(6)
Part VI Internal Malignant Neoplasms and Skin Diseases
Cutaneous Neoplasms and Cysts Associated with Internal Malignancy	311	(10)
Muir-Torre Syndrome	311	(3)
Cowden's Syndrome (Multiple Hamartoma and Neoplasia Syndrome)	314	(2)
Gardner's Syndrome	316	(1)
Birt-Hogg-Dube Syndrome	317	(4)
Epidermal Proliferative Processes Associated with Internal Malignancy	321	(7)
Acanthosis Nigricans	321	(2)
Bazex's Syndrome (Acrokeratosis Paraneoplastica)	323	(1)
Acquired Ichthyosis	323	(1)
Leser-Trelat Syndrome	324	(4)
Histiocytic Proliferations and Internal Malignancy	328	(6)
Necrobiotic Xanthogranuloma with Paraproteinemia	328	(2)
Multicentric Reticulohistiocytosis	330	(1)
Normolipemic Planar Xanthoma	331	(3)
Miscellaneous Cutaneous Lesions	334	(9)
Paraneoplastic Pemphigus	334	(1)
Erythema Gyratum Repens	335	(1)
Superficial (Migratory) Thrombophlebitis	336	(1)
Paraneoplastic Vasculitis	337	(1)
Sweet's Syndrome (Acute Febrile Neutrophilic Dermatosis)	337	(2)
Pityriasis Rotunda	339	(4)
The Skin and Metastatic Diseases	343	(8)
Part VII Pediatric Diseases with Prominent Cutaneous Features
Congenital Disorders	351	(24)
Down's Syndrome	351	(2)
Rothmund-Thomson Syndrome	353	(1)
Bloom's Syndrome	354	(1)
Ataxia-Telangiectasia	355	(1)
Progeria	356	(1)
Albinism	356	(1)
McCune-Albright Syndrome	357	(1)
Waardenburg's Syndrome	358	(1)
Xeroderma Pigmentosa	358	(2)
Cockayne's Syndrome	360	(1)
Dyskeratosis Congenita	360	(1)
Proteus Syndrome	361	(1)
Basal Cell Nevus Syndrome (Gorlin's Syndrome)	362	(1)
Lipoid Proteinosis (Hyalinosis Cutis et Mucosae)	363	(1)
Epidermolysis Bullosa	364	(1)
Congenital Nevus (Giant)	365	(10)
Index	375