Design of Enzyme Inhibitors As Drugs Volume 2

by Sandler, Merton; Smith, H. John

• ISBN13: 9780192621344
• ISBN10: 0192621343
• Format: Hardcover
• Copyright: 1994-05-26
• Publisher: Oxford University Press

Summary

Outlining the latest developments in the design of enzyme inhibitors as potent drugs in the treatment of disease and infection, Volume 2 extends on the previous volume in providing a comprehensive coverage of more recently recognised target enzymes and their known inhibitors. It demonstrates how the drug designer uses all available information to develop a specific therapeutic agent. The text outlines the steps involved in developing these drugs - from initial inception to satisfactory marketing - a process thwart with potential difficulties and involving the skills ofchemists, biochemists, pharmacologists, and clinicians.A fascinating insight into the world of drug development, this second volume will certainly maintain the position as the text in this field.

Table of Contents

Preface

Enzyme inhibitors as drugs: from design to the clinic

Computer-aided molecular design of enzyme inhibitors

Protein serine - threonine kinases

Inhibitors of protein tyrosine kinases

Inhibitors of non-protein kinases

Enzyme targets as an approach to therapy for HIV infections

Inhibitors of viral DNA Polymerase

Fungal enzyme targets

Steroidogenesis pathway enzymes

HMG-Co A reductase inhibitors

DNA topoisomerases

Catecholamine - O- methyltrasnferase (COMT) and COMT inhibitors

Inhibitors of Phospholipase A

Inhibitors of gastric H+, K+ ATPase

Inhibitors of mammalian collagenases

Inhibitors of Aldose Reductase

Miscellaneous topics

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