Designing Safer Chemicals Green Chemistry for Pollution Prevention

by Devito, Stephen C.; Garrett, Roger L.

• ISBN13: 9780841234437
• ISBN10: 0841234434
• Format: Hardcover
• Copyright: 1996-05-05
• Publisher: American Chemical Society

Summary

Covers the design or redesign of chemicals with the specific intent of making them safe for people and the environment. Explains how commercially useful substances of low toxicity can be designed and developed through careful forethought and strategic molecular modification. Describes how existing industrial chemicals that are toxic can be redesigned to be less toxic but retain their usefulness. Discusses how to merge the disciplines of toxicology and chemistry to design new, less toxic commercial chemicals or redesign existing toxic commercial chemicals to result in less toxic substitutes. Provides researchers, developers, and manufacturers of industrial chemicals with a reference source for designing safer chemicals.

Table of Contents

Preface
Pollution Prevention, Green Chemistry, and the Design of Safer Chemicals	p. 2
General Principles for the Design of Safer Chemicals: Toxicological Considerations for Chemists	p. 16
Cancer Risk Reduction Through Mechanism-Based Molecular Design of Chemicals	p. 62
Isosteric Replacement of Carbon with Silicon in the Design of Safer Chemicals	p. 74
Design of Biologically Safer Chemicals Based on Retrometabolic Concepts	p. 84
Predicting Rates of Cytochrome-P450-Mediated Bioactivation and Its Application to the Design of Safer Chemicals	p. 116
Use of Computers in Toxicology and Chemical Design	p. 138
Designing Biodegradable Chemicals	p. 156
Designing Aquatically Safer Chemicals	p. 172
Designing Safer Nitriles	p. 194
Designing an Environmentally Safe Marine Antifoulant	p. 224
Imine-Isocyanate Chemistry: New Technology for Environmentally Friendly, High-Solids Coatings	p. 234
Author Index	p. 247
Affiliation Index	p. 247
Subject Index	p. 247
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