Detection of Highly Dangerous Pathogens

by Editor: Tanja Kostic (Austrian Research Centers, Seibersdorf, Austria); Editor: Patrick Butaye (Veterinary and Agrochemical Research Center, Brussels, Belgium); Editor: Jacques Schrenzel (University Hospitals of Geneva, Switzerland)

• ISBN13: 9783527322756
• ISBN10: 3527322752
• Format: Hardcover
• Copyright: 2009-06-01
• Publisher: Blackwell Pub

Summary

Written by leading experts in the field as part of an interdisciplinary pan-European research program funded by the EU, this book provides a unique and comprehensive overview of how microarray technology can be used in safely tracking the most highly dangerous pathogens. A must-have for public health agencies focused on bioterrorism as well as all laboratories working with BSL3 and/or BSL 4 agents.

Author Biography

Tania Kostic is a researcher in the Department of Bioresources/Microbiology at the Austrian Research Centers at Seibersdorf working on microbial diagnostic microarrays.

Patrick Butaye is a veterinary researcher at the Veterinary and Agrochemical Research Center in Brussels with a focus on antimicrobial resistance in bacteria from animal origin.

Jacques Schrenzel is a physician and microbiologist, heading the central bacteriological laboratory of the Hopitaux Universitaires de Geneve. He is also a consultant for infectious diseases and is in charge of the genome research laboratory.

Table of Contents

Preface

Introduction on Microarray-based Detection Methods

Methods

Long-oligonucleotide Microarray-based Microbial Detection

Sequence-specific End-labelling of Oligonucleotides (SSELO)

Non-cognate Approaches for Pathogen Detection on Microarrays

Patterning Techniques for Array Platforms

Probe Immobilization Techniques in Array Technologies

Identification

Low-Cost-and-Density (LCD)-Microarrays - a Novel Technique for Identification and Typing of Microorganisms

DNA Microarray Technique for Detection and Identification of Viruses Causing Encephalitis and Hemorrhagic Fever

Microarrays for genomotyping of pathogens

Typing

Single Nucleotide Polymorphisms (SNPs) as Targets for DNA-array Based Identification and Typing of BSL3 Bacteria

Use of a Microchip to Detect Antibiotic Resistance Genes in Bacillus anthracis

Quality Control

Progress Toward Development of Microarrays for Routine Diagnostic Use for Detection of Select High Risk Pathogens

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