Development, Dynamics and Pathology of Neuronal Networks: From Molecules to Functional Circuits

by van Pelt; Kamermans; Levelt; van Ooyen; Ramakers; Roelfsema

• ISBN13: 9780444516633
• ISBN10: 0444516638
• Edition: 1st
• Format: Hardcover
• Copyright: 2004-12-13
• Publisher: Elsevier Science
• More Book Details
• Purchase Benefits

Summary

This book is about neuronal networks within the brain. with roughly 100 billion nerve cells the human brain contains about 3.2 million kilometers of 'wires' to make a million billion of connections between these nerve cells. Nerve cells exchange electrical and chemical signals through these connections and the dynamical patterns of electrical/chemical signals are the basis of all our thinking, memories, consciousness, and control of our behaviour. How do these networks develop their specific connectivity, what are the patterns of electrical activity that serve such a fundamental role in our cognitive abilities, how can it go wrong in these networks resulting in different types of brain pathologies, such as mental retardation, Alzheimers disease, epilepsy or schizophrenia? These questions are among the most fundamental ones in neuroscience and are addressed in this volume. The chapters in this book cover both state-of-the-art broad reviews and in-depth studies of topics selected in order to bridge different levels of neurobiological organization, from the molecular, cellular, neural network to the cognitive level. An excellent example of such a 'red thread' is given by the chapters devoted to the visual system, illustrating the advanced state of understanding of network development, plasticity and functioning of the visual system. Other chapters illustrate how scientific advances are driven by technical developments as shown for multi-electrode recording and life imaging techniques that enable the study of electrical activity simultaneously in many nerve cells.

Table of Contents

List of Contributors	v
Preface	ix
Acknowledgments	xi
Section I. Neuronal Network Formation
Neuronal network formation in human cerebral cortex	3	(14)
G.J.A. Ramakers
Section II. Molecular and Cell Biological Mechanisms of Neuronal Network Development and Synapse Formation
Regulation of dendritic growth by calcium and neurotrophin signaling	17	(12)
P.A. Dijkhuizen
A. Ghosh
Dynamics and pathology of dendritic spines	29	(10)
S. Halpain
K. Spencer
S. Graber
Introduction to the sixteenth C.U. Ariens Kappers lecture	39	(4)
D.F. Swaab
J. van Pelt
M.A. Hofman
Mechanisms of retinotopic map development: Ephs, ephrins, and spontaneous correlated retinal activity	43	(24)
D.D.M. O'Leary
T. McLaughlin
Biologically plausible models of neurite outgrowth	67	(14)
G. Kiddie
D. McLean
A. Van Ooyen
B. Graham
Competition in neurite outgrowth and the development of nerve connections	81	(22)
A. Van Ooyen
Section III. Synapse Rearrangement
Molecular substrates of plasticity in the developing visual cortex	103	(12)
S.A. Taha
M.P. Stryker
Excitatory--inhibitory balance and critical period plasticity in developing visual cortex	115	(10)
T.K. Hensch
M. Fagiolini
Structural plasticity in the developing visual system	125	(16)
M. Bence
C.N. Levelt
Mechanisms controlling the formation of retinal mosaics	141	(14)
E. Novelli
V. Resta
L. Galli-Resta
Laminar circuit formation in the vertebrate retina	155	(18)
J.S. Mumm
L. Godinho
J.L. Morgan
D.M. Oakley
E.H. Schroeter
R.O.L. Wong
Section IV. Structure and Dynamics in Neurons and Neuronal Networks
Dynamics and plasticity in developing neuronal networks in vitro	173	(16)
J. Van Pelt
I. Vajda
P.S. Wolters
M.A. Corner
G.J.A. Ramakers
Learning in ex-vivo developing networks of cortical neurons	189	(12)
S. Marom
D. Eytan
Role of synaptic inhibition in spatiotemporal patterning of cortical activity	201	(4)
L. Bosman
J.C. Lodder
A. Van Ooyen
A.B. Brussaard
Synaptic mechanisms that shape visual signaling at the inner retina	205	(14)
P.D. Lukasiewicz
The involvement of glutamate-gated channels in negative feedback from horizontal cells to cones	219	(12)
I. Fahrenfort
J. Klooster
T. Sjoerdsma
M. Kamermans
Compensatory physiological responses to chronic blockade of amino acid receptors during early development in spontaneously active organo-typic cerebral cortex explants cultured in vitro	231	(20)
M.A. Corner
R.E. Baker
J. Van Pelt
P.S. Wolters
Section V. Dynamics in Neural Circuits in Cognition
A visual salience map in the primate frontal eye field	251	(12)
K.G. Thompson
N.P. Bichot
Chronic multiunit recordings in behaving animals: advantages and limitations	263	(22)
H. Super
P.R. Roelfsema
Section VI. Deficient Circuitry and Cognitive/Behavioral Pathology
Physiological studies of information processing in the normal and Parkinsonian basal ganglia: pallidal activity in Go/No-Go task and following MPTP treatment	285	(10)
G. Morris
Y. Hershkovitz
A. Raz
A. Nevet
H. Bergman
Rho proteins, mental retardation and the neurobiological basis of intelligence	295	(24)
E.J.M. Van Galen
G.J.A. Ramakers
Neurodevelopment, neuroplasticity, and new genes for schizophrenia	319	(28)
S.E. Arnold
K. Talbot
C.-G. Hahn
The impact of seizures on developing hippocampal networks	347	(8)
J.W. Swann
Alzheimer's disease as a disorder of dynamic brain self-organization	355	(24)
T. Arendt
Subject Index	379