Dipeptidyl Aminopeptidases in Health and Disease

by Hildebrandt, Martin; Klapp, Burghard F.; Hoffman, Torsten; Demuth, Hans-Ulrich

• ISBN13: 9780306477171
• ISBN10: 0306477173
• Format: Hardcover
• Copyright: 2003-04-01
• Publisher: Plenum Pub Corp

Summary

Proceedings of the International Conference on Dipeptidyl Aminopeptidases, held September 26-28, 2002, in Berlin, Germany.Dipeptidyl Aminopeptidases exert a potent modulatory role at an interface between immune mechanisms, metabolic responses and neuroendocrine pathways. Experimental models and clinical studies addressing the role of these enzymes and the effect of specific inhibitors pave the way to novel therapeutic concepts in immunology, rheumatology, oncology, reproductive medicine and diabetes.Leading experts in this field have contributed to this book which presents a state-of-the-art view on these enzymes, at a time when our understanding of their function is growing ever more rapidly and therapeutic options become imminent. The sections of the book focus on various topics:- Structure and function of dipeptidyl aminopeptidases, - DPP IV-like proteins, - Immune mechanisms and immune disorders, - Cancer and angiogenesis, - Diabetes and metabolism, - Therapeutic implications.

Table of Contents

Structure and Function of Dipeptidyl Aminopeptidases
Dipeptidyl Peptidase IV Substrates	3	(16)
Ingrid de Meester
Anne-Marie Lambeir
Paul Proost
Simon Scharpe
Structure-Function Relationship of DPP IV: Insights into its Dimerisation and Gelatinase Activity	19	(10)
Oliver Baum
Werner Reutter
Felix Bermpohl
Exploration of the Active Site of Dipeptidyl Peptidase IV From Porphyromonas gingivalis	29	(8)
Anne-Marie Lambeir
Dean Rea
Vilmos Fulop
Yumi Kumagai
Koen Augustyns
Ingrid de Meester
Achiel Haemers
Simon Scharpe
Modification of the Biological Activity of Chemokines by Dipeptidyl Peptidase IV -- a Side Effect in the Use of Inhibitors?	37	(12)
Rolf Mentlein
Florian Schiemann
Andreas Ludwig
Ernst Brandt
Molecular Chimeras and Mutational Analysis in the Prolyl Oligopeptidase Gene Family	49	(8)
Katerina Ajami
Catherine A. Abbot
Vanessa Gysbers
Thilo Kahne
Geoffrey W. McCaughan
Mark D. Gorrell
The Specificity of DP IV for Natural Substrates is Peptide Structure Determined	57	(8)
Kerstin Kuhn-Wache
Torsten Hoffmann
Susanne Manhart
W. Brandt
Hans-Ulrich Demuth
New Results on the Conformations of Potent DP IV (CD26) Inhibitors Bearing the N-terminal MWP Structural Motif	65	(4)
Carmen Mrestani-Klaus
Wolfgang Brandt
Jurgen Faust
Sabine Wrenger
Dirk Reinhold
Siegfried Ansorge
Klaus Neubert
Different Inhibition Mechanisms of Dipeptidyl Peptidase IV by Tryptophan Containing Peptides and Amides	69	(4)
Angela Stockel-Maschek
Beate Stiebitz
Jurgen Faust
Ilona Born
Thilo Kahne
Mark D. Gorrell
Klaus Neubert
Re-Uptake Mechanisms of Peptide Fragments after DPP IV-Mediated Proteolysis in the Peripheral Nervous System	73	(6)
Q. Thai Dinh
Christian Peiser
Axel Fischer
David A. Groneberg
DPP IV-Like Enzymes
Dipeptidyl Peptidase IV Gene Family	79	(8)
Tong Chen
Katerina Ajami
Geoffrey W. McCaughan
Mark D. Gorrell
Catherine A. Abbott
Seprase-DPPIV Association and Prolyl Peptidase and Gelatinase Activities of the Protease Complex	87	(8)
Giulio Ghersi
H. Dong
L.A. Goldstein
Y. Yeh
L. Hakkinen
H.S. Larjava
W-T. Chen
Dipeptidyl Peptidase-IV Activity and/or Structure Homologues (DASH) in Transformed Neuroectodermal Cells	95	(8)
Radek Malik
Petr Busek
Vladislav Mares
Jan Sevcik
Zdenek Kleibl
Aleksi Sedo
Characterisation of Human DP IV Produced by a Pichia pastoris Expression System	103	(6)
Joachim W. Baer
Bernd Gerhartz
Torsten Hoffmann
Fred Rosche
Hans-Ulrich Demuth
Isolation and Characterization of Attractin-2	109	(6)
Daniel Friedrich
Kerstin Kuhn-Wache
Torsten Hoffmann
Hans-Ulrich Demuth
Investigation of DP IV-dependent Protein-Protein Interactions using Surface Plasmon Resonance	115	(8)
Joerg Stork
Torsten Hoffmann
Hans-Ulrich Demuth
Immune Mechanisms and Immune Disorders
Synergistic Action of DPIV and APN in the Regulation of T Cell Function	123	(10)
Uwe Lendeckel
Marco Arndt
Alicja Bukowska
Janine Tadje
Carmen Wolke
Thilo Kahne
Klaus Neubert
Jurgen Faust
Annelore Ittenson
Siegfried Ansorge
Dirk Reinhold
CD26/DPP IV in Experimental and Clinical Organ Transplantation	133	(12)
Stephan Korom
Ingrid de Meester
A. Belyaev
Georg Schmidbauer
Konrad Schwemmle
CD26 is Involved in the Regulation of T-Cell Plasma Membrane Compartmentation	145	(10)
Juan Lojo
Francisco J. Salgado
Montserrat Nogueira
Oscar J. Cordero
Inhibition of Dipeptidylpeptidase IV (DPP IV, CD26) Activity Modulates Surface Expression of CTLA-4 in Stress-Induced Abortions	155	(10)
Jens Ruter
Hans-Ulrich Demuth
Petra C. Arck
Torsten Hoffmann
Burghard F. Klapp
Martin Hildebrandt
Dipeptidyl Peptidase IV/CD26 in T Cell Activation, Cytokine Secretion and Immunoglobulin Production	165	(10)
Hua Fan
Shuling Yan
Sabine Stehling
Didier Marguet
Detlef Schuppan
Werner Reutter
Dipeptidyl Peptidase IV Inhibitors with the N-terminal MXP Sequence: Structure-Activity-Relationships	175	(6)
Jurgen Faust
Petra Fuchs
Sabine Wrenger
Dirk Reinhold
Angela Stockel-Maschek
Thilo Kahne
Siegfried Ansorge
Klaus Neubert
On the Role of Dipeptidyl Peptidase IV in the Digestion of an Immunodominant Epitope in Celiac Disease	181	(8)
Sina Koch
Dorit Anthonsen
Hanne Skovbjerg
Hans Sjostrom
The Properties of Human and Bovine CD8+CD26+ T Cells Induced by a Microbial Superantigen	189	(8)
Sang-Un Lee
Yong-Ho Park
William C. Davis
Lawrence K. Fox
Gregory A. Bohach
Angiogenesis and Cancer
DPPIV and Seprase in Cancer Invasion and Angiogenesis	197	(8)
W.-T. Chen
Glutamate Carboxypeptidase II Inhibition as a Novel Therapeutic Target	205	(10)
Camilo Rojas
Ajit G. Thomas
Pavel Majer
Takashi Tsukamoto
X.-C. May Lu
James J. Vornov
Krystyna M. Wozniak
Barbara S. Slusher
Dual Role of Dipeptidyl Peptidase IV (DPP IV) in Angiogenesis and Vascular Remodeling	215	(8)
Joanna Kitlinska
Edward W. Lee
Lijun Li
Jennifer Pons
Lori Estes
Zofia Zukowska
CD26 Expression on Cutaneous Infiltrates from Patients with Cutaneous T-Cell Lymphoma (CTCL)	223	(12)
Mauro Novelli
Alessandra Comessatti
Pietro Quaglino
Paola Savoia
Maria T. Fierro
Maria G. Bernengo
Intrahepatic Expression of Collagen and Fibroblast Activation Protein (FAP) in Hepatitis C Virus Infection	235	(10)
Mark D. Gorrell
Xin M. Wang
Miriam T. Levy
Eleanor Kable
George Marinos
Guy Cox
Geoffrey W. McCaughan
Expression of CD26/Dipeptidyl Peptidase IV in Endometrial Adenocarcinoma and its Negative Correlation with Tumor Grade	245	(4)
Hiroaki Kajiyama
Fumitaka Kikkawa
Kazuhiko Ino
Kiyosumi Shibata
Shigehiko Mizutani
Adhesion Potency to Mesothelial Cells by Overexpression of Dipeptidyl Peptidase IV	249	(4)
Fumitaka Kikkawa
Hiroaki Kajiyama
Kazuhiko Ino
Kiyosumi Shibata
Shigehiko Mizutani
Survival Time and Invasive Activity due to Dipeptidyl Peptidase IV Overexpression in Ovarian Carcinoma	253	(4)
Shigehiko Mizutani
Hiroaki Kajiyama
Takahiro Suzuki
Kiyosumi Shibata
Kazuhiko Ino
Fumitaka Kikkawa
Dipeptidylpeptidase IV Activities in Prostatic Secretions	257	(6)
Michael J. Wilson
Ross Haller
Joel W. Slaton
Neil F. Wasserman
Akhouri A. Sinha
Diabetes and Metabolism
Implementation of GLP-1 Based Therapy of Type 2 Diabetes Mellitus Using DPP-IV Inhibitors	263	(18)
Jens J. Holst
Dipeptidyl Peptidase IV Inhibition in Animal Models of Diabetes	281	(12)
J. Andrew Pospisilik
Jan A. Ehses
Timothy Doty
Christopher H.S. McIntosh
Hans-Ulrich Demuth
Raymond A. Pederson
Glucose-dependent Insulinotropic Polypeptide (GIP): Development of DP IV-Resistant Analogues with Therapeutic Potential	293	(10)
Simon A. Hinke
Francis Lynn
Jan Ehses
Nathalie Pamir
Susanne Manhart
Kerstin Kuhn-Wache
Fred Rosche
Hans-Ulrich Demuth
Raymond A. Pederson
Christopher H.S. McIntosh
Neutral Endopeptidase 24.11 and Dipeptidyl Peptidase IV are Both Involved in Regulating the Metabolic Stability of Glucagon-like Peptide-1 in vivo	303	(10)
Astrid Plamboeck
Jens J. Holst
Richard D. Carr
Carolyn F. Deacon
DPP IV, Immune Parameters, and Psychometrical Variables in Patients with Eating Disorders	313	(8)
Herbert Fliege
Matthias Rose
Burghard F. Klapp
Martin Hildebrandt
DPP IV and Mental Depression in Crohn's Disease	321	(12)
Matthias Rose
Otto B. Walter
Herbert Fliege
Martin Hildebrandt
Hubert Monnikes
Burghard F. Klapp
Microscopic Acid-Base Equilibra of Alanyl-boroAlanine	333	(6)
Jack H. Lai
Yuhong Zhou
James L. Sudmeier
Wengen Wu
David G. Sanford
Maw Hliang
Sarah Poplawski
William W. Bachovchin
Acylated Hydroxamates as Selective and Highly Potent Inhibitors of Dipeptidyl Peptidase I	339	(6)
Andre J. Niestroj
Dagmar Schlenzig
Ulrich Heiser
Kerstin Kuhn-Wache
Blas Cigic
Michael Werman
Torsten Hoffmann
Bernd Gerhartz
Hans-Ulrich Demuth
CD26-/DPP IV-Positive Lymphocytes in Murine Acute Experimental Colitis	345	(6)
Sabiha Fatima
Jens Ruter
Jan H. Niess
Burghard F. Klapp
Petra C. Arck
Martin Hildebrandt
Neuroprotective Effects of Inhibitors of Dipeptidyl Peptidase-IV in vitro and in vivo	351	(6)
Yong-Qian Wu
David C. Limburg
Douglas E. Wilkinson
Paul Jackson
Joseph P. Steiner
Gregory S. Hamilton
Sergei A. Belyakov
Index	357