Disorders of Voluntary Muscle

by George Karpati , Edited by David Hilton-Jones , Kate Bushby , Robert C. Griggs

• ISBN13: 9780521876292
• ISBN10: 052187629X
• Edition: 8th
• Format: Hardcover
• Copyright: 2010-02-26
• Publisher: Cambridge University Press

Summary

This major new edition fulfils the need for a single-volume, up-to-date information resource on the etiology, pathogenesis, diagnosis and treatment of diseases of skeletal muscles, including the muscular dystrophies, mitochondrial myopathies, metabolic myopathies, ion channel disorders, and dysimmune myopathies. As background to the clinical coverage, relevant information on advances in molecular and developmental biology, immunopathology, mitochondrial biology, ion-channel dynamics, cell membrane and signal transduction science, and imaging technology is summarized. Combining essential new knowledge with the fundamentals of history-taking and clinical examination, this extensively illustrated book will continue to be the mainstay for practising physicians and biomedical scientists concerned with muscle disease. Regular updates on the clinical and basic science aspects of muscle disease - written mainly by rising stars of myology - will be published on an accompanying website.

Table of Contents

Preface

Foreword

The Scientific Basis of Muscle Disease

Structure and function of muscle fibres and motor units

Myogenic precursor cells

Biochemical and molecular basis of muscle disease

Investigation of Muscle Disease

Electromyography and related techniques

Histopathology and immunoanalysis of muscle

Ultrastructural study of muscle

Diagnostic imaging of muscle

Description of Muscle Disease

General Aspects:

The clinical assessment and a guide to classification of the myopathies

The principles of molecular therapies for muscle diseases

Specific Diseases:

Dystrophinopathies

Muscular dystrophies presenting with proximal muscle weakness

Dystrophies and myopathies of early childhood onset

Congenital myopathies

Muscle diseases with prominent muscle contractures

Facioscapulohumeral muscular dystrophy

Distal myopathies

Oculopharyngeal muscular dystrophy

Myotonic dystrophy

Mitochondrial myopathies and related disorders

Metabolic myopathies

Muscle ion channelopathies and related disorders

Inflammatory and dysimmune myopathies

Myasthenia gravis and myasthenic syndromes [autoimmune and genetic]

Endocrine and toxic myopathies

Myofibrillar myopathy

Hereditary inclusion body myopathies

Other myopathies

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