DNA Damage and Repair

by Nickoloff, Jac A.; Hoekstra, Merl F.

• ISBN13: 9780896038035
• ISBN10: 0896038033
• Format: Hardcover
• Copyright: 2001-03-01
• Publisher: Humana Pr Inc

Summary

Jac A. Nickoloff and Merl F. Hoekstra update and expand their two earlier acclaimed volumes (Vol. I: DNA Repair in Prokaryotes and Lower Eukaryotes and Vol. II: DNA Repair in Higher Eurkaryotes) with cutting-edge reviews by leading authorities of primary experimental findings about DNA repair processes in cancer biology. The reviews cover a wide range of topics from viruses and prokaryotes to higher eukaryotes, and include several new topics, among them the role of recombination in replication of damaged DNA, X-ray crystallographic analysis of DNA repair protein structures, DNA repair proteins and teleomere function, and the roles of BRCA1 and BRCA2 in DNA repair. Authoritative and up-to-date, DNA Damage and Repair, Vol. III: Advances from Phage to Humans surveys the rapidly moving research in DNA damage and repair, and explains the important functional relationships among different DNA repair pathways and the relationship between DNA repair pathways, cancer etiology, and cancer therapies.

Table of Contents

Preface	v
Contents of Volume 1	ix
Contents of Volume 2	xi
Contributors	xiii
DNA Repair in Bacteriophage	1	(20)
Carol Bernstein
Harris Bernstein
Post-Replication Repair: A New Perspective Focusing on the Coordination Between Recombination and DNA Replication	21	(22)
Steven J. Sandler
Abasic Site Repair in Higher Eukaryotes	43	(44)
Phyllis R. Strauss
Noreen E. O'Regan
Structure and Functions of the Major Human AP Endonuclease HAP1/Ref-1	87	(20)
Ian D. Hickson
Michael A. Gorman
Paul S. Freemont
Mating-Type Control of DNA Repair and Recombination in Saccharomyces cerevisiae	107	(18)
Jac A. Nickoloff
James E. Haber
DNA End-Processing and Heteroduplex DNA Formation During Recombinational Repair of DNA Double-Strand Breaks	125	(22)
Galina Petukhova
Eva Y.-H. P. Lee
Patrick Sung
The MRE11-RAD50 Complex: Diverse Functions in the Cellular DNA Damage Response	147	(26)
John H. J. Petrini
Richard S. Maser
Debra A. Bressan
Repair of DNA Double-Strand Breaks and Mismatches in Drosophila	173	(34)
Carlos C. Flores
Double-Strand Break Repair and Homologous Recombination in Mammalian Cells	207	(30)
Maria Jasin
BRCA1 and BRCA2 in DNA Repair and Genome Stability	237	(32)
Mark A. Brenneman
DNA Repair and the Generation of Immune Diversity: The Agony and the Ecstasy	269	(46)
Lauryl M. J. Nutter
Chrystal K. Palaty
Martin Nemec
Cynthia J. Guidos
Jayne S. Danska
Interaction of Cell-Cycle Checkpoints with Muscle Differentiation	315	(14)
Troy Fiddler
Jing Huang
Elizabeth Ostermeyer
Teresa Johnson-Pais
Mathew J. Thayer
Ultraviolet Light-Induced and Spontaneous Recombination in Eukaryotes: Roles of DNA Damage and DNA Repair Proteins	329	(30)
Colin A. Bill
Jac A. Nickoloff
Telomeres, DNA Repair Proteins, and Making Ends Meet	359	(18)
Susan M. Bailey
Julianne Meyne
Edwin H. Goodwin
Conservation of Eukaryotic DNA Repair Mechanisms	377	(26)
Alan R. Lechmann
Elaine M. Taylor
Index	403