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9780521176354

DNA Microarrays and Gene Expression: From Experiments to Data Analysis and Modeling

by
  • ISBN13:

    9780521176354

  • ISBN10:

    0521176352

  • Edition: Revised
  • Format: Paperback
  • Copyright: 2011-04-28
  • Publisher: Cambridge University Press

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Summary

Massive data acquisition technologies, such as genome sequencing, high-throughput drug screening, and DNA arrays are in the process of revolutionizing biology and medicine. Using the mRNA of a given cell, at a given time, under a given set of conditions, DNA microarrays can provide a snapshot of the level of expression of all the genes in the cell. Such snapshots can be used to study fundamental biological phenomena such as development or evolution, to determine the function of new genes, to infer the role individual genes or groups of genes may play in diseases, and to monitor the effect of drugs and other compounds on gene expression. This inter-disciplinary introduction to DNA arrays will be essential reading for both biology and computer science researchers wanting to take advantage of this powerful new technology.

Table of Contents

Preface
A brief history of genomics
DNA array formats
DNA array readout methods
Gene expression profiling experiments: problems, pitfalls and solutions
Statistical analysis of array data: inferring changes
Statistical analysis of array data: dimensionality reduction, clustering, and regulatory regions
Survey of current DNA array applications
Systems biology: overview of regulatory, metabolic and signaling networks
Table of Contents provided by Publisher. All Rights Reserved.

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