DNA Repair in Cancer Therapy

by Panasci, Lawrence C.; Alaoui-Jamali, Moulay A.

• ISBN13: 9781588292988
• ISBN10: 1588292983
• Format: Hardcover
• Copyright: 2004-03-01
• Publisher: Humana Pr Inc

Summary

A comprehensive review of the recent developments in DNA repair that have potential for translational and clinical applications. The authors explain in detail the various mechanisms by which cancer cells can circumvent anticancer therapy and limits its usefulness in patients. They also review the clinical impact of such novel inhibitors of DNA repair mechanisms as methylguanine-DNA-methyltransferase. Also examined are inhibitors of other DNA repair enzymes such as PARP and DNA-PK, now under development and close to clinical trials. The book captures-for both cancer researchers and practicing oncologists dealing with hallmark "relapse" or "drug resistance" phenomena on a daily basis-the many exciting new uses of DNA repair inhibitors, either alone or in combination with anticancer therapies.

Table of Contents

Preface	v
Contributors	ix
Clinical Resistance to Alkylators: Status and Perspective	1	(8)
Brian Leyland-Jones
Role of Nonhomologous End-Joining and Recombinational DNA Repair in Resistance to Nitrogen Mustard and DNA Crosslinking Agents	9	(22)
Lawrence C. Panasci
Zhi-Yuan Xu
Raquel Aloyz
Repair of DNA Interstrand Crosslinks Produced by Cancer Chemotherapeutic Drugs	31	(20)
Peter J. McHugh
John A. Hartley
Chemosensitization to Platinum-Based Anticancer Drugs: Current Trends and Future Prospects	51	(22)
Bertrand J. Jean-Claude
Regulation of DNA Repair and Apoptosis by p53 and Its Impact on Alkylating Drug Resistance of Tumor Cells	73	(36)
Istvan Boldogh
Kishor K. Bhakat
Dora Bocangel
Gokul C. Das
Sankar Mitra
Stress-Activated Signal Transduction Pathways in DNA Damage Response: Implications for Repair, Arrest, and Therapeutic Interventions	109	(34)
Moulay A. Alaoui-Jamali
P. James Scrivens
Martin Loignon
Overcoming Resistance to Alkylating Agents by Inhibitors of O6-Alkylguanine-DNA Alkyltransferase	143	(28)
Anthony E. Pegg
M. Eileen Dolan
Cellular Protection Against the Antitumor Drug Bleomycin	171	(26)
Dindial Ramotar
Huijie Wang
Chaunhua He
Potential Role of PARP Inhibitors in Cancer Treatment and Cell Death	197	(14)
Michele Rouleau
Guy G. Poirier
Relationship Among DNA Repair Genes, Cellular Radiosensitivity, and the Response of Tumors and Normal Tissues to Radiotherapy	211	(46)
David Murray
Adrian C. Begg
Strand-Break Repair and Radiation Resistance	257	(16)
George Shenouda
V(D)J Recombination and DNA Double-Strand-Break Repair: From Immune Deficiency to Tumorigenesis	273	(22)
Despina Moshous
Jean-Pierre de Villartay
Inherited Disorders of Genomic Instability and Cancer Susceptibility	295	(28)
Gary M. Kupfer
Role of BRCA1 and BRCA2 in DNA Repair and Potential Impact on Therapeutics	323	(16)
Razqallah Hakem
Genetic Variations in DNA Repair: Their Implications in Human Cancer Risk, Prevention, and Therapy	339	(14)
Jennifer J. Hu
Index	353