The Dopamine Receptors

by Neve, Kim A.

• ISBN13: 9781603273329
• ISBN10: 1603273328
• Edition: 2nd
• Format: Hardcover
• Copyright: 2009-11-01
• Publisher: Humana Pr Inc

Summary

Dopamine receptors are among the most validated drug targets for neuropsychiatric disorders such as schizophrenia and Parkinson's disease, and are potential targets for other disorders such as substance abuse, depression, Tourette's syndrome, and attention deficit hyperactivity disorder. The new knowledge brought from the creation and characterization of mice deficient in each of the subtypes and the development of increasingly subtype-selective agonists and antagonists has fueled many of the chapters new to this second edition, with the use of knock-out mice and subtype-selective drugs meriting discussion in stand-alone chapters. The field of G protein-coupled receptors has also advanced significantly since the first edition, with a model of GPCR signaling based on linear, compartmentalized pathways having been replaced by a more complex, richer model in which neurotransmitter effects are mediated by a signalplex composed of numerous signaling proteins, including multiple GPCRs, other types of receptors, such as ionotropic receptors, accessory and scaffolding proteins, and the effectors.

Table of Contents

Historical Overview: Introduction to the Dopamine Receptors	p. 1
Gene and Promoter Structures of the Dopamine Receptors	p. 23
Structural Basis of Dopamine Receptor Activation	p. 47
Dopamine Receptor Subtype-Selective Drugs: D1-Like Receptors	p. 75
Dopamine Receptor Subtype-Selective Drugs: D2-Like Receptors	p. 101
Dopamine Receptor Signaling: Intracellular Pathways to Behavior	p. 137
Dopaminergic Modulation of Glutamatergic Signaling in Striatal Medium Spiny Neurons	p. 175
Regulation of Dopamine Receptor Trafficking and Responsiveness	p. 193
Dopamine Receptor-Interacting Proteins	p. 219
Dopamine Receptor Oligomerization	p. 255
Dopamine Receptor Modulation of Glutamatergic Neurotransmission	p. 281
Unraveling the Role of Dopamine Receptors In Vivo: Lessons from Knockout Mice	p. 303
Dopamine Receptors and Behavior: From Psychopharmacology to Mutant Models	p. 323
Dopamine Modulation of the Prefrontal Cortex and Cognitive Function	p. 373
In Vivo Imaging of Dopamine Receptors	p. 399
Dopamine Receptors and the Treatment of Schizophrenia	p. 431
Dopamine Receptor Subtypes in Reward and Relapse	p. 479
Dopamine Receptors and the Treatment of Parkinson's Disease	p. 525
Dopamine Receptor Genetics in Neuropsychiatric Disorders	p. 585
Index	p. 633
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