Dopamine Transporters Chemistry, Biology, and Pharmacology

by Trudell, Mark L.; Izenwasser, Sari; Wang, Binghe

• ISBN13: 9780470117903
• ISBN10: 0470117907
• Edition: 1st
• Format: Hardcover
• Copyright: 2008-07-28
• Publisher: Wiley

Summary

Understanding the dopamine transporter can lead to new therapies for neurological disorders This book consolidates current information on the dopamine transporter (DAT) in relationto medicinal chemistry and synthesis, biology and pathology, and pharmacology. Because of DAT's role in diseases such as Parkinson's, schizophrenia, attention deficit hyperactivity disorder (ADHD), Tourette syndrome, and drug abuse (in particular, cocaine addiction), DAT research is an exploding field. Tremendous advances have been made toward understanding how it impacts a variety of neurological disease states and disorders. This reference provides a broad overview of current knowledge that is detailed enough to furnish a basic understanding of the biological, chemical, and pharmacological aspects of DAT in one comprehensive reference. With contributions from eminent scientists who are experts in their particular areas, Dopamine Transporters: Chemistry, Biology, and Pharmacology: * Reviews current studies and research in the areas of DAT function, pathological conditions, cloning, molecular structure, and electrochemical characterization * Covers findings in the medicinal chemistry of DAT-inhibitory ligands and substrates, discussing the chemical syntheses and summarizing the various structure-activity relationships of important classes of dopamine uptake inhibitors and dopamine releasers * Has chapters that focus on technologies for future DAT study, including imaging and in vivo and in vitro methods This is a hands-on reference for researchers, medicinal chemists, pharmacologists, and biologists working with DAT or related proteins and for students in related areas of study.

Author Biography

Mark L. Trudell, PHD, is University Research Professor of Chemistry at the University of New Orleans. He has authored over ninety published papers, holds three patents, and has overseen more than $6 million in research grants.

Sari Izenwasser, PHD, is Professor in the Department of Psychiatry and Behavioral Sciences at the University of Miami Miller School of Medicine. She is author of three book chapters and over ninety peer-reviewed articles, and has overseen more than $7 million in research grants.

Table of Contents

Contributors	p. vii
Preface	p. xi
Biochemistry and Molecular Biology	p. 1
The Dopamine Transporter: An Anatomical Perspective	p. 3
Dopamine Transporter, Disease States, and Pathology	p. 29
Cloning and Genetic Analysis of Dopamine Transporters	p. 47
Molecular Structure and Composition of Dopamine Transporters	p. 73
Electrochemical Characterization of Dopamine Transporters	p. 97
Medicinal Chemistry	p. 123
Tropane-Based Dopamine Transporter-Uptake Inhibitors	p. 125
The Benztropines: Atypical Dopamine-Uptake Inhibitors That Provide Clues About Cocaine's Mechanism at the Dopamine Transporter	p. 171
Structure-Activity Relationship of GBR 12909 Ligands	p. 211
Structure-Activity Relationship Study of Piperidine Derivatives for Dopamine Transporters	p. 233
Non-Nitrogen-Containing Dopamine Transporter-Uptake Inhibitors	p. 265
Dopamine-Releasing Agents	p. 305
Pharmacology	p. 321
PET/SPECT Imaging Studies of the Plasma Membrane Dopamine Transporter	p. 323
In Vitro Studies of Dopamine Transporter Function and Regulation	p. 347
In Vivo Studies of Dopamine Transporter Function	p. 391
Index	p. 439
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