This is an inclusive reference exploring the scientific basis and practice of drug therapy. The key concept is to look at the balance between the benefits and risks of drugs but in this context also the social impact which drugs have in modern societies is highlighted. Taking an evidence-based approach to the problem, the practice of clinical pharmacology and pharmacotherapy in the developing as well as the developed world is examined. For this purpose the book * Covers general clinical pharmacology, pharmacology of various drug groups and the treatments specific to various diseases * Gives guidance on how doctors should act so that drugs can be used effectively and safely * Encourages the rational use of drugs in society This book brings together a large amount of excellent content that will be invaluable for anyone working within, or associated with, the field of clinical pharmacology and pharmacotherapy - undergraduates, postgraduates, regulatory authorities and the pharmaceutical industry.

Chris J. van Boxtel is the editor of Drug Benefits and Risks: International Textbook of Clinical Pharmacology, published by Wiley.

Budiono Santoso is the editor of Drug Benefits and Risks: International Textbook of Clinical Pharmacology, published by Wiley.

I. Ralph Edwards is the editor of Drug Benefits and Risks: International Textbook of Clinical Pharmacology, published by Wiley.

List of Contributors

vii

Foreword

xi

Preface

xiii

Section I General Principles

1

(1)

Part A Medicinals in Society

1

(102)

The Role of Therapeutic Agents in Modern Medicine

3

(12)

Drug Benefits

3

(6)

Ronald D. Mann

Drug Risks

9

(6)

Jerry Avorn

Therapeutics as a Science

15

(12)

Marcus M. Reidenberg

Pharmacoepidemiology and Drug Evaluation

27

(10)

Supornchai Kongpatanakul

Brain L. Strom

Pharmacoeconomics

37

(18)

Kevin A. Schulman

Henry A. Glick

Daniel Polsky

K.R. John

John M. Eisenberg

National Drug Policy and the Role of Clinical Pharmacology

55

(6)

Marc Blockman

Peter I. Folb

Drug Regulation: Organization and Control

61

(10)

Budiono Santoso

Drugs in Developing Countries

71

(10)

Budiono Santoso

Sources of Drug Information

81

(10)

Joe Talmud

Drug Development

91

(12)

Peter van Brummelen

Part B General Clinical Pharmacology

103

(146)

Clinical Pharmacokinetics

105

(38)

Anthony J. Smith

Sri Suryawati

Clinical Pharmacodynamics

143

(16)

Gunnar Alvan

Gilles Paintaud

Monique Wakelkamp

Drug Therapy in Pediatric Patients

159

(16)

Gregory L. Kearns

Kim G. Adcock

John T. Wilson

Drug Therapy in Older Persons

175

(20)

Barry J. Cusack

Adverse Drug Reactions

195

(16)

I. Ralph Edwards

Drug-Drug Interactions

211

(16)

Anne Lee

Ivan H. Stockley

Drug Misuse-Harmful Use, Abuse and Dependence

227

(10)

I. Ralph Edwards

Clinical Pharmacology of Poisoning

237

(12)

Kenneth Y. Hartigan-Go

Section II Pharmacotherapeutic Products

249

(180)

Neurohumoral Transmission

251

(22)

M. Pfaffendorf

Drugs Acting on the Central Nervous System

273

(18)

Chris J. van Boxtel

A. Buitenhuis

Cardiovascular and Renal Drugs

291

(24)

P.A. van Zwieten

Antimicrobial Agents

315

(26)

Chris J. van Boxtel

Drugs Affecting Gastrointestinal Function

341

(10)

Chris J. van Boxtel

Hemopoietic Drugs and Drugs that Affect Coagulation

351

(8)

Chris J. van Boxtel

Hormones and Hormone Antagonists

359

(18)

Chris J. van Boxtel

Autacoids

377

(10)

M. Pfaffendorf

Analgesics, Antirheumatics and Drugs for the Treatment of Gout

387

(10)

Chris J. van Boxtel

Antineoplastic Agents

397

(12)

Chris J. van Boxtel

Drugs used for Immunomodulation

409

(6)

Chris J. van Boxtel

Vitamins

415

(6)

Chris J. van Boxtel

Agents used in Dermatology and Miscellaneous Agents

421

(8)

Chris J. van Boxtel

A. Buitenhuis

Section III Treatment of Health Problems

429

(254)

Symptomatic Treatment

431

(10)

Iwan Darmansjah

Inger Hagqvist

Emergency Medicine

441

(18)

Robin E. Ferner

Molly Thomas

Treatment and Prophylaxis of Infectious Diseases

459

(28)

Michiel A. van Agtmael

Inge C. Gyssens

Henri A. Verbrugh

Care and Support for People with HIV Infection

487

(6)

Joseph H. Perriens

Cardiovascular and Renal Diseases

493

(42)

Pharmacotherapy of Hypertension

493

(14)

Y.K. Seedat

Treatment of Ischemic Heart Disease

507

(4)

Tomonori Tateishi

Shinichi Kobayashi

Treatment of Congestive Heart Failure

511

(6)

Tomonori Tateishi

Shinichi Kobayashi

Pharmacological Treatment of Cardiac Arrhythmias

517

(8)

Hirotsugu Atarashi

Pharmacological Treatment of Renal Diseases

525

(10)

Y.K. Seedat

Gastrointestinal and Hepatobiliary Disorders

535

(16)

M.J.S. Langman

Pharmacotherapy of Chronic Obstructive Pulmonary Disease

551

(18)

Dieter Ukena

Disorders of Connective Tissue, Bone and Joints

569

(14)

John Darmawan

Treatment of Psychiatric Disorders

583

(12)

Nicholas Moore

Bernard Begaud

Neurological Diseases

595

(26)

Herve Allain

Stephane Schuck

Drug Use for Malignancies

621

(18)

Maja J. A. de Jonge

Jaap Verweij

Haematological Disorders

639

(20)

Peter Jacobs

Lucille Wood

Wendy Pepper

Endocrine Diseases

659

(24)

Robert Djokomoeljanto

Julian R. E. Davis

Index

683

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