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What is included with this book?
Drug transporter fundamentals and relevant principles and techniques, featuring new and expanded chapters
Drug Transporters: Molecular Characterization and Role in Drug Disposition provides in-depth analysis of the conceptual evolution and technical development for studying drug transporters. Contributions by an international panel of leading researchers address advances in transporters as drug targets, transporters in pharmacotherapy, the impact of transporters on drug efficacy and safety, the development of sophisticated model systems and sensitive assay methods, and more. Divided into two parts, the book first provides a thorough overview of relevant drug transporters before detailing the principles of drug transport and associated techniques.
The updated and expanded third edition includes new chapters on in vitro-in vivo scale-up of drug transport activities, the ontogeny of drug transporters, the application of physiologically-based pharmacokinetic and pharmacodynamic modeling, and the use of transporters as therapeutic targets for diseases.
Understandable for novices while offering sufficient depth for more experienced researchers, Drug Transporters: Molecular Characterization and Role in Drug Disposition, Third Edition is an excellent textbook for pharmacological or physiological science courses in drug/membrane transport, and an invaluable reference for academic or industrial scientists working in the transporter field and related areas of drug metabolism, pharmacokinetics, and pharmacodynamics.
Guofeng You, PhD, Distinguished Professor of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers University, New Jersey, USA.
Marilyn E. Morris, PhD, SUNY Distinguished Professor and Chair, Department of Pharmaceutical Sciences, University at Buffalo, State University of New York, USA.
List of Contributors
Preface
CHAPTER 1. Overview of Drug Transporter FamiliesGuofeng You and Marilyn E. Morris
CHAPTER 2. Organic Cation and Zwitterion TransportersMegan L. Koleske, Xiaomin Liang, Osatohanmwen Jessica Enogieru, Dina Buitrago, and KathleenM. Giacomini
CHAPTER 3. Multidrug and Toxin Extrusion ProteinsLauren M. Aleksunes, Victoria Woo, and Melanie S. Joy
CHAPTER 4. Organic Anion Transporters (OATs)Jeffry C. Granados, Jingui Zhang, Guofeng You, Sanjay K. Nigam
CHAPTER 5. Organic Anion Transporting Polypeptides OATPRommel G. Tirona and Richard B. Kim
CHAPTER 6. Mammalian Oligopeptide TransportersStephen M. Carl, Dea Herrera-Ruiz, Rajinder K. Bhardwaj, Olafur Gudmundsson, Stephanie Mowery, and Gregory T. Knipp.
CHAPTER 7. Monocarboxylic Acid TransportersMarilyn E. Morris and Nisha V. Kwatra
CHAPTER 8. The Nucleoside Transporters CNTs and ENTsRaj Govindarajan, Antonio López Quiñones, and Joanne Wang
CHAPTER 9. Bile Acid TransportersEbehiremen N. Ayewoh and Peter W. Swaan
CHAPTER 10. The P-glycoprotein Multidrug TransporterAndaleeb Sajid, Sabrina Lusvarghi and Suresh V. Ambudkar
CHAPTER 11. Multidrug Resistance Proteins of the ABCC SubfamilyAnne T. Nies and Franziska Klein
CHAPTER 12. ABCG2, the Breast Cancer Resistance Protein (BCRP)Robert W. Robey, Sabrina Lusvarghi, Cindy H. Chau, Agnes Basseville, William D. Figg, Suresh V. Ambudkar, and Susan E. Bates
CHAPTER 13. Drug Transport in the LiverNoora Sjöstedt, Jeffry Adiwidjaja, William A. Murphy, and Kim L.R. Brouwer
CHAPTER 14. Drug Transport in the BrainVishal Sangha, Erica I. Williams, Patrick T. Ronaldson, and Reina Bendayan
CHAPTER 15. Drug Transport in the KidneyDouglas H. Sweet
CHAPTER 16. Drug transporters in the human intestineStefan Oswald
CHAPTER 17. Drug Transport in the PlacentaQingcheng Mao, Vadivel Ganapathy, and Jashvant D. Unadkat
CHAPTER 18. Polymorphisms of drug transporters and clinical relevanceTore B. Stage and Deanna L. Kroetz
CHAPTER 19. Ontogeny of Drug TransportersMelanie A. Felmlee and Qing Zhang
CHAPTER 20. Experimental Approaches for Studying Drug TransportersYusuke Masuo, Azusa Futatsugi, and Yukio Kato
CHAPTER 21. Transporters mediated drug disposition – Physiochemistry and in silico approachesManthena V. S. Varma, Ayman El-Kattan, and Yurong Lai
CHAPTER 22. In vitro-in vivo scale-up of drug transport activitiesKazuya Maeda and Yuichi Sugiyama
CHAPTER 23. Application of Physiologically Based Pharmacokinetic and Pharmacodynamic (PBPK/PD) Modeling Comprising Transporters: Delineating the Role of Various Factors in Drug Disposition and ToxicityMatthew D. Harwood, Amin Rostami-Hodjegan, and Sibylle Neuhoff
CHAPTER 24. Transporters as therapeutic targets in human diseasesRobert S. Jones and Eugene C. Chen
CHAPTER 25. Diet/Nutrient Interactions with Drug TransportersMarilyn E. Morris and Tianjing Ren
Index
The New copy of this book will include any supplemental materials advertised. Please check the title of the book to determine if it should include any access cards, study guides, lab manuals, CDs, etc.
The Used, Rental and eBook copies of this book are not guaranteed to include any supplemental materials. Typically, only the book itself is included. This is true even if the title states it includes any access cards, study guides, lab manuals, CDs, etc.