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Author #1:
After earning his doctorate in experimental psychology at the University of New Mexico in 1971, Dr. Grilly spent the next two years investigating the behavioral effects of cannabinoids after acute and chronic exposure in chimpanzees at Holloman Air Force Base in Alamogordo, New Mexico. He then moved to Cleveland, Ohio, to take a position as a faculty member in the Psychology Department at Cleveland State University, where he spent the remainder of his 38 year career. His research at CSU, primarily with rats, involved investigations of a variety of psychoactive drugs on a variety of behaviors. These included investigating the potential use of signal detection theory in assessing nociception and opiate withdrawal, determining the effects of drugs on attentional processes (e.g., naltrexone, diprenorphine, morphine, barbiturates, amphetamine, cocaine, fluoxetine, nicotine, pemoline) and conditioned avoidance/escape behavior (e.g., clonidine, chlorpromazine, morphine), determining whether the effects of psychostimulants (e.g., cocaine, amphetamine) on sustained attention change with aging, and comparing the effects of very low to very high doses of amphetamine in rats with those shown in humans. He also conducted research with humans investigating the effect of marijuana on visual short term memory and the changes in people’s perceptions of the effects of marijuana on driving.
Author #2: Dr. John Salamone received his bachelor's degree from Rockhurst University in Kansas City, Missouri in 1978. He was a psychology major and biology minor. Dr. Salamone then entered the psychobiology program at Emory University in Atlanta, Georgia, and graduated with a Ph.D. in 1982. For postdoctoral training, Dr. Salamone received a National Science Foundation grant, and studied at Cambridge University in England. Dr. Salamone stayed in England for several more years, working at Merck, Sharpe and Dohme pharmaceutical laboratories. Upon returning to the United States, Dr. Salamone joined the Behavioral Neuroscience department at the University of Pittsburgh in 1986, and joined the Psychology Department at UConn in the fall of 1988. Dr. Salamone is now a Board of Trustees Distinguished Professor; he also is the chair of the Interdisciplinary Program in Neuroscience, and the head of the Behavioral Neuroscience Division of the Psychology Department. Dr. Salamone's research is largely in the fields of behavioral neuroscience and psychopharmacology, with an emphasis on studies related to Parkinson’s disease, depression, motivation, and effort-related decision making. Dr. Salamone has been the research advisor for more than 40 undergraduate honors students at the University of Connecticut. He was inducted as a member of the Connecticut Academy of Arts and Sciences in 2002, and he has received the University of Connecticut Alumni Association Award for Excellence in Teaching. His daughter, Isabella Salamone, is currently an honor student studying biology at the University of Pittsburgh. Dr. Salamone’s hobbies include travel, astronomy, book collecting and cooking.
IN THIS SECTION:
1.) BRIEF
2.) COMPREHENSIVE
BRIEF TABLE OF CONTENTS:
Chapter 1: Psychopharmacology in Perspective
Chapter 2: Drug Classification and Behavioral Assessment
Chapter 3: Basic Principles of Pharmacology
Chapter 4: Excitability and Chemical Properties of Nerve Cells
Chapter 5: Synaptic Transmission, Drugs, & Chemical Neuroanatomy
Chapter 6: Tolerance, Sensitization, Dependence & Addiction
Chapter 7: Psychomotor Stimulants & Antiparkinsonian Drugs
Chapter 8: Antipsychotic Drugs & Neurochemical Hypotheses of Schizophrenia
Chapter 9: Antidepressants & Mood Stabilizers
Chapter 10: Sedative-Hypnotics, Anxiolytics and Anticonvulsants
Chapter 11: Drug Treatment of Cognitive Dysfunction
Chapter 12: Naturally Occurring & Synthetic Opiates & their Antagonists
Chapter 13: Dissociative Anesthetics, Psychedelics, & Hallucinogens
COMPREHENSIVE TABLE OF CONTENTS:
Chapter 1: Psychopharmacology in Perspective
A Historical Overview of Psychopharmacology
Predecessors to Modern Pharmacotherapies
The Psychopharmacological Revolution
Recreational and Social Drug Use
Summary and Overview
Chapter 2: Drug Classification and Behavioral Assessment
Drug Classifications Based upon Behavioral or Therapeutic Actions
Drug Classification Based upon Basic Neurochemical Actions
Drug Names and Medical Uses of Drugs
Schedule-Controlled Drugs
Chapter 3: Basic Principles of Pharmacology
Basic Chemical Principles Related to Psychopharmacology
Routes of Administration
Importance of the Blood-Brain Barrier in Psychopharmacology
Dose—Response Relationships
Drug Metabolism and Excretion
Implications of Pharmacokinetics in the Fetus and Neonate
Pharmacogenetic and Ethnic Factors in Drug Action
Chapter 4: Excitability and Chemical Properties of Nerve Cells
The Neuron
Electrical Excitability of Neurons: The Resting Membrane Potential
Electrical Excitability of Neurons: Excitation, Inhibition, and the Action Potential
Integration, Computation and Chemical Signaling in Neurons
Additional Features of Chemical Neurotransmission
Chapter 5: Synaptic Transmission, Drugs, & Chemical Neuroanatomy
Neurotransmitters & Chemical Signaling in the Nervous System
Synthesis of Neurotransmitters
Storage of Neurotransmitters
Release of Neurotransmitters
Postsynaptic Actions of Neurotransmitters
Inactivation of Neurotransmitters
Chemical Neuroanatomy & Neurotransmitter Distribution
Chapter 6: Tolerance, Sensitization, Dependence & Addiction
Tolerance& Sensitization
Tolerance & Sensitization Mechanisms
Dependence, Abuse & Addiction
General Factors in Treatment for Drug Dependency
State-Dependent Learning
Chapter 7: Psychomotor Stimulants & Antiparkinsonian Drugs
Motor Effects of Psychomotor Stimulants
Caffeine
Nicotine
Amphetamines and Related Drugs
Cocaine
Treatment of Cocaine and Amphetamine Abuse
Modafinil
Parkinson’s Disease
Chapter 8: Antipsychotic Drugs & Neurochemical Hypotheses of Schizophrenia
Symptoms of Schizophrenia
Discovery and Characterization of Antipsychotic Drugs
Neurochemical and Neuropathological Hypotheses of Schizophrenia
Current Pharmacotherapy for Schizophrenia
Chapter 9: Antidepressants & Mood Stabilizers
Pharmacotherapy for Depression
Neurobiological Hypotheses of Affective Disorders
Nondrug Treatments for Depression
Placebo Effects and Antidepressant Actions
Pharmacotherapy in Mania and Bipolar Illnesses
Chapter 10: Sedative-Hypnotics, Anxiolytics and Anticonvulsants
Alcohol (Ethanol)
Barbiturates and Other Sedative—Hypnotics
Inhalants: Anesthetic Gases and Solvents
Anxiolytics
Sedative—Hypnotics and Insomnia
Drug Treatment of Epilepsy: Anticonvulsant Drugs
Chapter 11: Drug Treatment of Cognitive Dysfunction
Attention Deficit Hyperactivity Disorder
Psychomotor Stimulants, Learning, & Memory
Treatment of Alzheimer’s Disease & Senile Dementia
Chapter 12: Naturally Occurring & Synthetic Opiates & their Antagonists
Endogenous Opioid Peptides and Their Receptors
Typical Opiates
The “Overdose” Phenomenon
Legal Factors in the Narcotics Problem
Opiate Antagonists: Potential Uses
Chapter 13: Dissociative Anesthetics, Psychedelics, & Hallucinogens
Some General Characteristics of P/P/Hs
Monoamine-Related P/P/Hs
Cannabinoids
Dissociative Anesthetics: Phencyclidine and Ketamine
Dissociative Anesthetics, Psychedelics & Hallucinogens: The Human Experience
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