Dystonia 3

by Fahn, Stanley

• ISBN13: 9780781715386
• ISBN10: 0781715385
• Format: Hardcover
• Copyright: 1998-08-01
• Publisher: Lippincott Williams & Wilkins

Table of Contents

Contributing Authors	xi	(10)
Preface	xxi	(2)
Acknowledgments	xxiii
I. CLASSIFICATION AND PATHOPHYSIOLOGY	1	(78)
1. Classification of Dystonia	1	(10)
Stanley Fahn
Susan B. Bressman
Charles David Marsden
2. Physiology of Dystonia	11	(8)
Mark Hallett
3. Pathophysiology of Dystonia	19	(8)
Alan R. Crossman
Jonathan M. Brotchie
4. Thalamic Single Neuron and Electromyographic Activities in Patients with Dystonia	27	(6)
T.A. Zirh
Stephen G. Reich
V. Perry
Frederick A. Lenz
5. Excitability of Motor Cortex in Patients with Dystonia	33	(8)
Antonio Curra
A. Berardelli
Sabine Rona
S. Fabri
Mario Manfredi
6. Opioid Peptide Precursor Expression in Animal Models of Dystonia Secondary to Dopamine-Replacement Therapy in Parkinson's Disease	41	(12)
Jonathan M. Brotchie
Brian Henry
Christopher J. Hille
Alan R. Crossman
7. Characterization of a Rodent Model in Which to Investigate the Molecular and Cellular Mechanisms Underlying the Pathophysiology of L-dopa-Induced Dyskinesia	53	(10)
Brian Henry
Alan R. Crossman
Jonathan M. Brotchie
8. Abnormal Cerebellar Output in the Genetically Dystonic Rat	63	(16)
Mark S. LeDoux
Joan F. Lorden
II. GENETICS OF PRIMARY TORSION DYSTONIA	79	(48)
9. Clinical-Genetic Spectrum of Primary Dystonia	79	(14)
Susan B. Bressman
Deborah de Leon
Deborah Raymond
Laurie J. Ozelius
Xandra O. Breakefield
Torbjoern G. Nygaard
Laura Almasy
Neil J. Risch
Patricia L. Kramer
10. The Gene (DYT1) for Early-Onset Torsion Dystonia Encodes a Novel Protein Related to the Clp Protease/Heat Shock Family	93	(14)
Laurie J. Ozelius
Jeffrey W. Hewett
Curtis E. Page
Susan B. Bressman
Patricia L. Kramer
Christo Shalish
Deborah de Leon
Mitchell F. Brin
Deborah Raymond
David Jacoby
John Penney
Neil J. Risch
Stanley Fahn
James F. Gusella
Xandra O. Breakefield
11. The Role of the DYTI Gene in Secondary Dystonia	107	(10)
Susan B. Bressman
Deborah de Leon
Deborah Raymond
Paul E. Greene
Mitchell F. Brin
Stanley Fahn
Laurie J. Ozelius
Xandra O. Breakefield
Patricia L. Kramer
Neil J. Risch
12. Familial Cervical Dystonia, Head Tremor, and Scoliosis: A Case Report	117	(4)
Drake D. Duane
13. The Epidemiology of the Primary Dystonias in the North of England	121	(6)
Philip O.F. Duffey
Anthony G. Butler
Maurice R. Hawthorne
Michael P. Barnes
III. PET SCANS OF DYSTONIA	127	(42)
14. Abnormal Brain Networks in DYTI Dystonia	127	(8)
David Eidelberg
15. Activation Positron Emission Tomography Scanning in Dystonia	135	(18)
Andres O. Ceballos-Baumann
David J. Brooks
16. Advanced Neuroimaging Methods in the Study of Movement Disorders: Dystonia and Blepharospasm	153	(8)
John C. Mazziotta
Michael Hutchinson
Terry D. Fife
Roger Woods
17. Decreased [(18)F] Spiperone Binding in Putamen in Dystonia	161	(8)
Joel S. Perlmutter
Mikula K. Stambuk
Joanne Markham
Kevin J. Black
Lori McGee-Minnich
Joseph Jankovic
Stephen M. Moerlein
IV. THERAPEUTICS	169	(84)
18. Medical Therapy and Botulinum Toxin in Dystonia	169	(16)
Joseph Jankovic
19. Surgical Treatment of Dystonia	185	(14)
Anthony E. Lang
20. Intrathecal Baclofen in the Treatment of Dystonia	199	(12)
Blair Ford
Paul E. Greene
Elan D. Louis
Susan B. Bressman
Robert R. Goodman
Mitchell F. Brin
Saud Sadiq
Stanley Fahn
21. GPi Pallidotomy for Dystonia: Clinical Outcome and Neuronal Activity	211	(10)
Jerrold L. Vitek
J. Zhang
M. Evatt
Klaus Mewes
Mahlon R. DeLong
Takao Hashimoto
S. Triche
R.A.E. Bakay
22. Experience with Stereotactics for Dystonia: Case Examples	221	(6)
Robert P. Iacono
Sandra M. Kuniyoshi
Tony Schoonenberg
23. Botulinum Toxin Type B: An Open-Label, Dose-Escalation, Safety and Preliminary Efficacy Study in Cervical Dystonia Patients	227	(4)
Paul A. Cullis
Christopher F. O'Brien
Daniel D. Truong
Martin Koller
Timothy P. Villegas
J.D. Wallace
24. Dose Standardization of Botulinum Toxin	231	(6)
Peter Y.K. Van den Bergh
Dominique F. Lison
25. Laryngeal Dystonia (Spasmodic Dysphonia): Observations of 901 Patients and Treatment with Botulinum Toxin	237	(16)
Mitchell F. Brin
Andrew Blitzer
Celia Stewart
V. DOPA-RESPONSIVE DYSTONIA	253	(72)
26. Dystonias Responding to Levodopa and Failure in Biopterin Metabolism	253	(14)
Yoshiko Nomura
Kimiaki Uetake
Shoko Yukishita
Hiroaki Hagiwara
Tatsuroh Tanaka
Ritsuho Tanaka
Kei Hachimori
Nobuyoshi Nishiyama
Masaya Segawa
27. Molecular and Biochemical Aspects of Hereditary Progressive and Dopa-Responsive Dystonia	267	(16)
Yoshiaki Furukawa
Mitsunobu Shimadzu
Oleh Hornykiewicz
Stephen J. Kish
28. Atypical Presentations of Dopa-Responsive Dystonia	283	(8)
Oliver Bandmann
Charles David Marsden
Nicholas W. Wood
29. Tetrahydrobiopterin Metabolism and GTP Cyclohydrolase I Mutations in L-Dopa-Responsive Dystonia	291	(10)
Laurent Bezin
Panagiotis Z. Anastasiadis
Torbjoern G. Nygaard
Robert A. Levine
30. Defects of Biopterin Metabolism and Biogenic Amine Biosynthesis: Clinical, Diagnostic, and Therapeutic Aspects	301	(8)
Keith Hyland
Lauren A. Arnold
Joel M. Trugman
31. Dopa-Responsive Dystonia: A Syndrome of Selective Nigrostriatal Dopamine Deficiency	309	(10)
Beom S. Jeon
Jae-Min Jeong
Sung-Sup Park
Myung-Chul Lee
32. The Effect of GTP Cyclohydrolase-1 on Tyrosine Hydroxylase Expression: Implications in DOPA-responsive Dystonia	319	(6)
Un Jung Kang
Craig Bencsics
Stephen Wachtel
Robert Lew
VI. OTHER DYSTONIA SYNDROMES	325	(24)
33. Inherited Myoclonus-Dystonia Syndrome	325	(10)
Thomas Gasser
34. Rapid-Onset Dystonia-Parkinsonism: A Report of Clinical, Biochemical, and Genetic Studies in Two Families	335	(6)
Allison Brashear
Ian J. Butler
Laurie J. Ozelius
Patricia L. Kramer
Martin R. Farlow
Xandra O. Breakefield
William B. Dobyns
35. Molecular Genetic Analysis of Lubag	341	(8)
Kirk C. Wilhelmsen
Carol B. Moskowitz
Daniel E. Weeks
Michael Neystat
Torbjoern G. Nygaard
Lorraine Clark
Muriel Dancoup
Eufemio E. Sobrevega
Raymond Rosales
Gilberto L. Gamez
Orlino Pacioles
Martesio Perez
Stanley Fahn
VII. PATIENT PERSPECTIVES	349	(10)
36. The Socioeconomic Implications of Dystonia	349	(10)
Anthony G. Butler
Philip O.F. Duffey
Maurice R. Hawthorne
Michael P. Barnes
VIII. SUMMARY AND CONCLUSIONS	359	(6)
37. Summary and Conclusions	359	(6)
Charles David Marsden
Stanley Fahn
Subject Index	365