Dystonia 4

by Fahn, Stanley; Hallett, Mark; DeLong, Mahlon R.

• ISBN13: 9780781746007
• ISBN10: 0781746000
• Edition: 1st
• Format: Hardcover
• Copyright: 2003-09-11
• Publisher: LWW

Summary

Written by leading international experts in all relevant clinical and basic science disciplines, Dystonia 4 is a state-of-the-art review of recent progress in the understanding and treatment of the dystonias. It provides a comprehensive update on the many breakthroughs that have occurred in the five years since the highly acclaimed Dystonia 3 was published. The therapeutics section features detailed discussions on botulinum toxin treatment and current surgical procedures. The book also includes a major section on recent advances in understanding the genetics of the dystonias. Other sections focus on pathophysiology, Oppenheim's dystonia, PET and biochemical studies, and musician's and other focal dystonias.

Table of Contents

Contributing Authors	xi
Preface	xxi
Acknowledgments	xxiii
I: Pathophysiology
1. Dystonia: Abnormal Movements Result from Loss of Inhibition	1	(10)
Mark Hallett
2. Sensory Deficits in Dystonia and Their Significance	11	(8)
Rvuji Kaji, Nagako Murase, Ryo Urushihara, and Kotaro Asanuma
3. Focal Hand Dystonia May Result from Aberrant Neuroplasticity	19	(10)
Nancy N. Byl
4. Basal Ganglia Neuronal Discharge in Primary and Secondary Dystonia	29	(8)
Manjit K. Sanghera, Robert G. Grossman, Christopher G. Kalhorn, Winifred J. Hamilton, William G. Ondo, and Joseph Jankovic
5. Evidence of Widespread Impairment of Motor Cortical Inhibition in Focal Dystonia: A Transcranial Magnetic Stimulation Study in Patients With Blepharospasm and Cervical Dystonia	37	(8)
Raif Cakmur, Berril Donmez, Fatma Uzunel, Huriye Aydin, and Serdar Kesken
6. Modulation of Cortical Activity by Repetitive Transcranial Magnetic Stimulation (rTMS): A Review of Functional Imaging Studies and the Potential Use in Dystonia	45	(8)
Saga R. Filipovic, Hartwig R. Siebner, James B. Rowe, Carla Cordivari, Willibald Gerschlager, John C. Rothwell, Richard S.J. Frackowiak, and Kailash P. Bhatia
II: Oppenheim's Dystonia
7. Dopamine Transmission in DYT1 Dystonia	53	(8)
Sarah J. Augood, Z. Hollingsworth, David S. Albens, Lichuan Yang, Joanne C. Leung, Xandra O. Breakefield, and David G. Standaert
8. Development and Anatomic Localization of TorsinA	61	(6)
Shelley R. Oberlin, Marina Konakova, Stefan Pulst, and Marie-Françoise Chesselet
9. Mouse Models of TorsinA Dysfunction	67	(6)
William Dauer and Rose Goodchild
10. Dominant TorsinA Mutations in Cellular Systems	73	(6)
Melisa J. Baptista, Casey A. O'Farrell, and Mark R. Cookson
11. An Animal Model to Discern Torsin Function: Suppression of Protein Aggregation in C. elegans	79	(8)
Guy A. Caldwell, Songsong Cao, Christopher C. Gelwix, Elaina G. Sexton, and Kim A. Caldwell
12. TorsinA and Early-Onset Torsion Dystonia	87	(8)
D. Cristopher Bragg, Damien J. Slater, and Xandra O. Breakefield
13. An Epidemiologic Survey of Dystonia Within the Entire Population of Northeast England Over the Past Nine Years	95	(6)
Anthony G. Butler, Philip O.F. Duffey, Maurice R. Hawthorne, and Michael P. Barnes
III: Other Genetic Disorders
14. Dystonia Genotypes, Phenotypes, and Classification	101	(8)
Susan B. Bressman
15. Update on the Genetics of Primary Torsion Dystonia Loci DYT6, DYT7, and DYTJ3 and the Dystonia-Plus Locus DYTJ2	109	(4)
Laurie J. Ozelius
16. Inherited Myoclonus-Dystonia	113	(8)
Friedrich Asmus and Thomas Gasser
17. Penetrance and Expression of Dystonia Genes	121	(6)
Rachel Saunders-Pullman, Janet Shriberg, Vicki Shanker, and Susan B. Bressman
18. Update on Dopa-Responsive Dystonia: Locus Heterogeneity and Biochemical Features	127	(12)
Yoshiaki Furukawa
19. X-Linked Recessive Dystonia Parkinsonism (XDP; Lubag; DYTS)	139	(4)
Andrew Singleton, Stephen Hague, and Dena Hernandez
20. Focal Dystonia Is Associated With a Polymorphism of the Dopamine D5 Receptor Gene	143	(4)
Anjum Misbahuddin, Mark R. Placzek, and Thomas T. Warner
21. Dystonia with and without Deafness Is Caused by TIMM8A Mutation	147	(8)
Russell H. Swerdlow, Vern C. Juel, and G. Frederick Wooten
IV: PET and Biochemistry of Dystonia
22. Abnormal Brain Networks in Primary Torsion Dystonia	155	(8)
Maren Carbon, Maja Trost, Marie Felice Ghilardi, and David Eidelberg
23. Dysfunction of Dopaminergic Pathways in Dystonia	163	(8)
Joel S. Perlmutter and Jonathan W. Mink
24. Clinical Presentation and Progression of Sporadic and Familial Primary Torsion Dystonia in Italy	171	(8)
Anna Rita Bentivoglio, Antonio Emanuele Elia, Graziella Filippini, Enza Maria Valente, Alfonso Fasano, and Alberto Albanese
25. Cognition and Affect in Patients With Cervical Dystonia With and Without Tremor	179	(12)
Drake D. Duane and Kendall J. Vermilion
26. Clinical Features of the Geste Antagoniste in Cervical Dystonia	191	(12)
Saša R. Filipovic, Marjan Jahanshahi, Ramachandran Viswanathan, Peter Heywood, Daniel Rogers, and Kailash P. Bhatia
27. Executive Function in Dystonia	203	(8)
Marjan Jahanshahi, John Rowe, and Rebecca Fuller
28. Duration of Effectiveness of Botulinum Toxin Type B in the Treatment of Cervical Dystonia	211	(6)
Mark F. Lew
29. Is Phenotypic Variation of Hereditary Progressive Dystonia with Marked Diurnal Fluctuation/Dopa-Responsive Dystonia Caused by the Difference of the Locus of Mutation on the GTP Cyclohydrolase 1 Gene?	217	(8)
Masaya Segawa, Yoshiko Nomura, Skoko Yukishita, Nobuyoshi Nishiyama, and Masayuki Yokochi
V: Musicians' and Other Focal Dystonias
30. Focal Task-Specific Dystonia in Musicians	225	(6)
Steven J. Frucht
31. Brain Mapping in Musicians with Focal Task-Specific Dystonia	231	(8)
Michael E. Charness and Gottfried Schlaug
32. Three-Dimensional Movement Analysis as a Promising Tool for Treatment Evaluation of Musicians' Dystonia	239	(8)
Hans-Christian Jabusch and Eckart Altenmüller
33. Limb Immobilization for Occupational Dystonia: A Possible Alternate Treatment for Selected Patients	247	(8)
Alessandra Pesenti, Sergio Barbieri, and Alberto Priori
34. A Review of 113 Musicians with Focal Dystonia Seen Between 1985 and 2002 at a Clinic for Performing Artists	255	(2)
Alice G. Brandfonbrener and Chester Robson
35. The Impact of Focal Dystonia on the Working Life of Musicians in the United Kingdom	257	(4)
Anthony G. Butler; Philip O.F. Duffey, Maurice R. Hawthorne, and Michael P. Barnes
36. Long-Term Outcome of Focal Dystonia in Instrumental Musicians	261	(6)
Stephan U. Scheele and Richard J. Lederman
37. Abnormal Sensorimotor Processing in Pianists With Focal Dystonia	267	(8)
Vanessa K. Lim, John L. Bradshaw, Michael E.R. Nicholls, and Eckart Altenmüller
VI: Therapeutics
38. Dystonia: Medical Therapy and Botulinum Toxin	275	(12)
Joseph Jankovic
39. Pallidotomy for Generalized Dystonia	287	(14)
Blair Ford
40. Pallidal Stimulation for Dystonia	301	(8)
Andres M. Lozano and Aviva Abosch
41. Off Period Dystonia in Parkinson's Disease but Not Generalized Dystonia Is Improved By High-Frequency Stimulation of the Subthalamic Nucleus	309	(6)
Olivier Detante, Laurent Vercueil, Paul Krack, Stéphan Chabardes, Alim-Louis Benabid, and Pierre Pollak
42. Autonomic Side Effects of Botulinum Toxin Type B Therapy	315	(6)
Dirk Dressler and Reiner Benecke
43. Dystonia and Headaches: Clinical Features and Response to Botulinum Toxin Therapy	321	(8)
Nestor Galvez-Jimenez, Cristina Lampuri, Rosa Patiño-Picirrillo, Melanie J.A. Hargreave, and Maurice R. Hanson
44. Rating Scales for Dystonia: Assessment of Reliability of Three Scales	329	(8)
The Dystonia Study Group
Subject Index	337