The Effects of Estrogen on Brain Function

by Rasgon, Natalie L., M.D.

• ISBN13: 9780801882821
• ISBN10: 0801882826
• Edition: 1st
• Format: Hardcover
• Copyright: 2006-04-01
• Publisher: JOHNS HOPKINS UNIV PRESS

Summary

This timely volume reviews current data on the effects of estrogen on the central nervous system, highlighting clinical aspects of this topic. Experts from the fields of psychiatry, pharmacology, neurology, and geriatrics collaborate to clarify the known risks and benefits of hormone therapy and explore questions that remain to be elucidated. Among the topics discussed:" Preclinical data on estrogen's effects on cognitive performance" The short-lived effects of hormone replacement therapy on cognitive function" Structural and functional brain imaging data regardingestrogen's effects on the central nervous system " Preclinical efforts to develop effective NeuroSERMs for the brain " The effects of estrogen on mood Citing the ongoing confusion over the risks and benefits of estrogen therapy, the contributors emphasize the need for additional research on medication, doses, preparations, methods of administration, alternative therapies, and supplements. This volume educates researchers, clinicians, and students on the current knowledge -- including the effects of estrogen on mood, cognition, and brain metabolism -- and provides guidelines for clinical practice and future research. Contributors: Roberta Diaz Brinton, Ph.D., University of Southern California; Cheri L. Geist, B.A., David Geffen School of Medicine, University of California at Los Angeles; Robert B. Gibbs, Ph.D., University of Pittsburgh School of Pharmacy; Eva Hogervorst, Ph.D, University of Loughborough and University of Oxford; Pauline M. Maki, Ph.D., Neuropsychiatric Institute, University of Illinois--Chicago; Peter J. Schmidt, M.D., National Institute of Mental Health; Daniel H. S. Silverman, M.D., Ph.D., David Geffen School of Medicine, University of California at Los Angeles; Katherine E. Williams, M.D., Stanford University School of Medicine; Kristine Yaffe, M.D., University of California, San Francisco, and San Francisco VA Medical Center; Laurel N. Zappert, B.A., Stanford University School of Medicine; Liqin Zhao, Ph.D., University of Southern California.

Author Biography

Natalie L. Rasgon, M.D., Ph.D., is an associate professor in the departments of Psychiatry and Behavioral Sciences and Obstetrics and Gynecology at the Stanford University School of Medicine, where she is director for the Behavioral Neuroendocrinology and the Women's Wellness Programs.

Table of Contents

List of Contributors	vii
Introduction	1	(8)
Natalie L. Rasgon
Preclinical Data Relating to Estrogen's Effects on Cognitive Performance	9	(37)
Robert B. Gibbs
The Short-Lived Effects of Hormone Therapy on Cognitive Function	46	(33)
Eva Hogervorst
Clinical Data from Structural and Functional Brain Imaging on Estrogen's Effects in the Central Nervous System	79	(16)
Daniel H. S. Silverman
Cheri L. Geist
Natalie L. Rasgun
Clinical Data on Estrogen's Effects on Mood	95	(21)
Natalie L. Rasgon
Laurel N. Zappert
Katherine E. Williams
Preclinical Efforts to Develop Effective NeuroSERMs for the Brain	116	(28)
Roberia Diaz Brinton
Liqin Zhao
Basic and Clinical Data on the Effects of SERMs on Cognition	144	(21)
Kristine Yaffe
Pauline M. Maki
Peter L. Schmidt
Conclusion	165
Natalie L. Rasgon