Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 4

by Honn, Kenneth V.

• ISBN13: 9780306461385
• ISBN10: 0306461382
• Edition: 1st
• Format: Hardcover
• Copyright: 2000-02-01
• Publisher: SPRINGER

Summary

Since their discovery over sixty years ago, eicosanoids have come to r epresent a diverse family of bioactive lipid modulators, including pro staglandins, thromboxanes, leukotrienes, lipoxins, isoprostanes, hepox ilins, hydroxy acids, epoxy and hydroxy fatty acids. This book contain s conference presentations regarding the regulation of eicosanoid enzy mes and, in particular, cyclooxygenases, lipoxygenases, and phospholip ases. In addition, recent evidence over the last seven years has led t o the identification of a number of receptors for these bioactive lipi ds. The new field of isoprostanes is also represented. It has become i ncreasingly evident that eicosanoids play a critical role in signal tr ansduction, both in normal cells and in pathological processes. These aspects are discussed in relation to cellular events, such as apoptosi s, angiogenesis, and cancer prevention and treatment.

Table of Contents

REGULATION OF EICOSANOID ENZYMES
Function and Regulation of Prostaglandin Synthase 2	3	(6)
Harvey R. Herschman
Weilin Xie
Srinivasta Reddy
Regulation of Cyclooxygenase-2 by the Activated p38 MAPK Signaling Pathway	9	(8)
Zhonghong Guan
ShaAvhree Y. Buckman
Lisa D. Springer
Aubrey R. Morrison
Fatty Acid Cyclooxygenase Induction and Prostaglandin D Synthesis in a Human Megakaryoblastic Cell Line CMK Differentiated by Phorbol Ester	17	(6)
Shozo Yamamoto
Natsuo Ueda
Ishtiaq Mahmud
Hiroko Yamaguchi
Rieko Yamashita
Kei Yamamoto
Kazunori Ishimura
Yoshihiro Urade
Yoshihide Kanaoka
Osamu Hayaishi
Eicosanoid Metabolism in Human Platelets is Modified by Albumin	23	(6)
Marina Dadaian
Par Westlund
Diverse Functional Coupling or Prostanoid Biosynthetic Enzymes in various Cell types	29	(8)
Ichiro Kudo
Makoto Murakami
Regulation of Prostaglandin, Leukotriene, and Platelet-activating Factor Metabolism in Mast Cells	37	(6)
Makoto Murakami
Kinji Tada
Ko-ichi Nakajima
Ichiro Kudo
Lipid Peroxides and Neuronal Plasticity	43	(6)
Makoto Nishiyama
Nobuaki Hori
Takashi Watanabe
Tomokatsu Hori
Katsuhiko Ogata
Keiichi Watanabe
Eiichi Maru
Takao Shimizu
Secretion of Lipocalin-type Prostaglandin D Synthase (β-trace) from Human Heart to Plasma During Coronary Circulation	49	(6)
Yoshihiro Urade
Yutaka Eguchi
Naomi Eguchi
Yoshiyuki Kijima
Yasuhiko Matsu-ura
Hiroshi Oda
Kousuke Seiki
Osamu Hayaishi
Lipocalin-type Prostaglandin D Synthase (β-trace) Binds Non-Substrate Lipophilic Ligands	55	(6)
Carsten T. Beuckmann
Yoshihiro Urade
Osamu Hayaishi
Features of Mammalian Lipoxygenases	61	(6)
Bernd J. Thiele
Mario Berger
Holger Thiele
Antje Huth
Iris Reimann
Identification and Characterization of an Enhancer Sequence in the Promoter Region of Human 15-Lipoxygenase (15-LO) Gene	67	(8)
Uddhav Kelavkar
Susheng Wang
Angel Montero
Kamal Badr
Cytokine Induced Regulation of 15-Lipoxygenase and Phospholipid Hydroperoxide Glutathione Peroxidase in Human Cells	75	(8)
Kerstin Schnurr
Roland Brinckmann
Hartmut Kuhn
Investigation of a Second 15S-Lipoxygenase in Humans and Its Expression in Epithelial Tissues	83	(8)
Alan R. Brash
Mitsuo Jisaka
William E. Boeglin
Min S. Chang
Diane S. Keeney
Lillian B. Nanney
Susan Kasper
Robert J. Matusik
Sandra J. Olson
Scott B. Shappell
Sequence Determinants for the Positional Specificity of Mammalian and Plant Lipoxygenases	91	(8)
S. Borngraber
R-J. Kuban
Hartmut Kuhn
X-Ray Absorption Studies into the Iron Ligand Sphere of Plant and Animal Lipoxygenases	99	(6)
Hartmut Kuhn
R. Kuban
M. Walther
Gerrit A. Veldink
Transcriptional and Posttranscriptional Regulation of 5-Lipoxygenase mRNA Expression in the Human Monocytic Cell Line Mono Mac 6 by Transforming Growth Factor-β and 1,25-Dihydroxyvitamin D3	105	(10)
Damaris Harle
Olof Radmark
Bengt Samuelsson
Dieter Steinhilber
CYCLOOXYGENASES
Comparison of Prostaglandin H Synthase-1 and -2 Structural Stabilities	115	(4)
Guishan Xiao
Wei Chen
Richard J. Kulmacz
Modulation of the Expression of the Cyclooxygenase 1 and 2 Genes in Rat Mammary Glands: Role of Hormonal Status and Dietary Fat	119	(6)
Alaa F. Badawi
Ahmed El-Sohemy
Laurie L. Stephen
Amit K. Ghoshal
Michael C. Archer
Regulation of Cerebrovascular Cyclooxygenase-2 by Pro- and Anti-Inflammation Cytokines	125	(6)
Steven A. Moore
Elizabeth Yoder
Gretchen Rich
MacKenzie Hilfers
Jeffrey Albright
Visualization and Quantitation of Cyclooxygenase-1 and -2 Activity by Digital Fluorescence Microscopy	131	(8)
Richard L. Ornberg
Alane T. Koki
Discovery of a New Class of Selective Cyclooxygenase-2 (COX-2) Inhibitor that Convalently Modifies the Isozyme	139	(6)
Amit S. Kalgutkar
Brenda C. Crews
Scott W. Rowlinson
Carlos Garner
Lawrence J. Marnett
Mitigation of Arthritis by High-Dose Administration of a COX-2 Inhibitor in the Collagen-Induced Arthritis Model in the Mouse	145	(6)
Mark G. Obukowicz
Richard L. Ornberg
Indomethacin Inhibition of Pristane Plasmacytomagenesis in Genetically Susceptible Inbred Mice	151	(6)
Michael Potter
Role of COX-2 Inhibition on the Formation and Healing of Gastric Ulcers Induced by Indomethacin in the Rat	157	(8)
Nuria Godessart
Carolina Salcedo
Andres G. Fernandez
Jose M. Palacios
Regulation of in vivo Prostaglandin Biosynthesis by Glutathion	165	(4)
Alon Margalit
Peter C. Isakson
Scott D. Hauser
Different Effects of Reactive Nitrogen Intermediates on Prostaglandin E2 Synthesis in Cultured Rat Microglia and Raw 264.7 Cells	169	(8)
Cecilia Guastadisegni
Luisa Minghetti
Alessia Nicolini
Elisabetta Polazzi
Maria Balduzzi
Giulio Levi
PHOSPHOLIPASES/PAF
Activation of cPLA2 in Vascular Smooth Muscle	177	(6)
Edward F. LaBelle
Erzsebet Polyak
Role of Type IIA Secretory Phospholipase A2 in Arachidonic Acid Metabolism	183	(6)
Hiroshi Kuwata
Hisashi Sawada
Makoto Murakami
Ichiro Kudo
Phospholipase A2 is Involved in Chemotaxis of Human Leukocytes	189	(10)
Ulrich Tibes
Markus Hinder
Werner Scheuer
Walter-Gunar Friebe
Stephan Schramm
Beate Kaiser
Suppression of Acute Experimental Inflammation by Antisense Olgonucleotids Targeting Secretory Phospholipase A2 (sPLA2). In vitro and in vivo experiments	199	(10)
Ulrich Tibes
Sigrid P. Rohr
Werner Scheuer
Elke Amandi-Burgermeister
Anette Litters
Comparison of Recombinant Types IIA, V, and IIC Phospholipase A2S, The Three Related Mammalian Secretory Phospholipase A2 Isozymes	209	(6)
Satoko Shimbara
Makoto Murakami
Terumi Kambe
Ichiro Kudo
Respective Roles of the 14 KDA and 85 KDA Phospholipase A2 Enzymes in Human Monocyte Eicosanoid Formation	215	(6)
Lisa A. Marshall
Brian Bolognese
Amy Roshak
Modulation of Long-term Potentiation in the CA1 Area of Rat Hippocampus by Platelet-Activating Factor	221	(8)
Kunio Kato
RECEPTORS
Ppars: Nuclear Receptors for Fatty Acids, Eicosanoids, and Xenobiotics	229	(8)
Pallavi R. Devchand
Annemieke Ijpenberg
Beatrice Devesvergne
Walter Wahli
Molecular Cloning and Characterization of Leukotriene B4 Receptor	237	(8)
Takashi Izumi
Takehiko Yokomizo
Toshio Igarashi
Taka Shimizu
Determinants of Receptor Subtype Specificity in the LPA-like Lipid Mediator Family	245	(8)
G. Tigyi
D.J. Fischer
K. Liliom
Z. Guo
T. Virag
G. Sun
D.D. Miller
K. Murakami-Morofushi
s. Kobayashi
J.R. Erickson
Subunits and Cellular Occurrence of the 12(S)-HETE Binding Complex	253	(6)
Helena Herbertsson
Tobias Kuhme
Sven Hammarstrom
A Subfamily of G Protein-Coupled Cellular Receptors for Lysophospholipids and Lysosphingolipids	259	(6)
Edward J. Goetzel
Songzhu An
Evidence for Involvement of Prostaglandin I2 as a Major Nociceptive Mediator in Acetic Acid-Induced Writing Reaction: A Study Using IP-Receptor Distrupted Mice	265	(4)
Sachiko Oh-Ishi
Akinori Ueno
Hideki Matsumoto
Takahiko Murata
Fumitaka Ushikubi
Shuh Narumiya
Local Anesthetic Effects on TXA2 Receptor Mediated Platelet Aggregation Using Quenched Flow Aggregometry	269	(8)
Christian W. Honemann
Bernard Lo
Jo S. Errera
Renata Polanowski-Grabowska
Adrean RL Gear
Marcel Duriex
Volatile and Local Anesthetics Interfere with Thromboxane A2 Receptors Recombinantly Expressed in Xenopus Oocytes	277	(10)
Christian W. Honemann
John A. Arledge
Tobias Podranski
Hugo Van Aken
Marcel Durieux
LEUKOTRIENES AND LIPOXINS
Aspirin-Triggered 15-Epi-Lipoxin A4 and Novel Lipoxin B4 Stable Analogs Inhibit Neutrophil-Mediated Changes in Vascular Permeability	287	(8)
Charles N. Serhan
Tomoko Takano
Clary B. Clish
Karsten Gronert
Nicos Petasis
Clevage of Leukotriene D4 in Mice with Targeted Disruption of a Membrane-Bound Dipeptidase Gene	295	(6)
Geetha M. Habib
Michael W. Lieberman
γ-Glutamyl Leukotrienase Clevage of Leukotriene4	301	(6)
Michael W. Lieberman
Jefrey E. Shields
Yvonne Will
Donald J. Reed
Bing J. Carter
LTE4 Blood Levels in Infants with Congenital Heart Lesions	307	(6)
Jean Pierre Gascard
Charles Brink
Evaluation of the Pharmacological Activity of the Pure Crsteinyl-Leukotriene Receptor Antagonists CGP 45715A (Irakukast) and CGP 57698 in Human Airways	313	(6)
Valerie Capra
Saula Ravasi
Manlio Bolla
Serena Viappiani
Silvia Pagliardini
P. Angelo Belloni
Maurizio Mezzetti
G. Carlo Folco
Simonetta Nicosia
G. Enrico Rovati
Evidence for a Carbocation Intermediate in the Enzymatic Transformation of Leukotriene A4 into Leukotriene B4	319	(8)
Martiana
Mats Hamberg
Jespez Z. Haeggstrom
A Random Rapid Equilibrium Mechanism for Leukotriene C4 Synthase	327	(8)
Namrata Gupta
Michael J. Gresser
Anthony W. Ford-Hutchinson
ISOPROSTANES
Formation of Reactive Products of the Isoprostane Pathway: Isolevuglandins and Cyclopentenone Isoprostanes	335	(8)
L. Jackson Roberts, II
Cynthis J. Brame
Yan Chen
Jason D. Morrow
Robert G. Salomon
Formation of Novel Isoprostane-like Compounds from Docosahexaenoic Acid	343	(8)
Jason D. Morrow
Andrew R.
Tapper
William E. Zackert
James Yang
Stephanie C. Sanchez
Thomas J. Montine
L. Jackson Roberts
LYSOPHOSPHATIDIC ACID (LPA) AND LPA RECEPTORS
cDNA Cloning, Expression, and Chromosomal Localization of Two Human Lysophosphatidic Acid Acyltransferases	351	(6)
Christin Eberhardt
Patrick W. Gray
Larry W. Tjoelker
The First Cloned and Identified Lysophospholipid (LP) Receptor Gene, VSG-1: Implications for Related Receptors and the Nervous System	357	(8)
Jerold Chun
SIGNAL TRANSDUCTION
Involvement of Protein Kinase C, P38 Map Kinase and ERK in Arachidonic Acid Stimulated Superoxide Production in Human Neutrophils	365	(6)
Charles S.T. Hii
Zhi H. Huang
Andrea Bilney
Kathryn Stacey
Andrew W. Murray
Deborah A. Rathjen
Antonio Ferrante
13(S)-HPODE Augments Epidermal Growth Factor Signal Transduction by Attentuating EGF Receptor Dephosphorylation	371	(6)
Wayne C. Glasgow
Putai Hui
Shiranthi Jayawickreme
Julie Angerman-Steward
Bing-Bing Hang
Thomas E. Eling
Role of Lipoxygenase in the Regulation of Glucose Transport in Aortic Vascular Cells	377	(8)
Shlomo Sasson
Ana Davarashvili
Reuven Reich
Functions of the p21-Activated protein Kinases (PAKS) in Neutrophils and Their Regulation by Complex Lipids	385	(6)
Dwight Robinson
RiYun Huang
Jian P. Lian
Alex Toker
John A. Badwey
Inhibition of Neurofibromin and p120 GTPase Activating Protein (GAP) by Dietary Fatty Acids	391	(10)
Joung H. Lee
Jyoti A. Harwalker
Sophia S. Bryant
Vidyokhaya Sundaram
Richard Jove
Mladen Golubic
BIOACTIVE LIPIDS IN INFLAMMATION
Spinal Synthesis and Release of Prostanoids after Peripheral Injury and Inflammation	401	(8)
David M. Dirig
Tony L. Yaksh
Prostaglandin E2 as a Modulator of Lymphocyte Mediated Inflammatory and Humoral Responses	409	(4)
Kuljeet Kaur
Sarah G. Harris
Josue Padilla
Beth A. Graf
Richard P. Phipps
Lipid Mediators Stimulate Reactive Oxygen Species Formation in Immortalized Human Keratinocytes	413	(6)
Rachel Goldman
Snadra Moshonov
Uriel Zor
Nitric Oxide Synthesis is Increased in Periodontitis	419	(6)
Michael Matejka
Christian Ulm
Lukas Partyka
Martin Ulm
Helmut Sinzinger
Augmentation Effect of High Glucose on Endotoxin-Induced Nitric Oxide Production in Murine Macrophages	425	(6)
Soo H. Lee
Hyun Goo Woo
Ji Y. Kim
Chang-Hyun Moon
1,2-diacylglycerol Hydroperoxide Induced the Generation and Release of Superoxide Anion from Human Polymorphonuclear Leukocytes	431	(6)
Yorihiro Yamamoto
Yasuhiro Kambayashi
Takashi Ito
Keiichi Watanabe
Minoru Nakano
Kinetic Evaluation of Endogenous Leukotriene B4 and E4 Acute Activation of Inflammatory Cells in the Rabbit	437	(6)
Antonio Celardo
Giuseppe Dell'Elba
Stefano Manarini
Virgilio Evangelista
Giovanni de Gaetano
Chiara Cerletti
Lipopolysaccharide- and Liposome-Encapsulated MTP-PE-Induced Formation of Eicosanoids, Nitric Oxide and Tumor Necrosis Factor-α in Macrophages	443	(6)
P. Dieter
U. Hempel
B. Malessa
E. Fitzke
T.A. Tran-Thi
J. MacLouf
C. Creminon
Y. Kanaoka
Y. Urade.
LTA4 Hydrolase Expression During Glomerular Inflammation: Correlation of Immunohistochemical Localization with Cytokine Regulation	449	(6)
Angel Montero
Susumu Uda
Karen A. Munger
Kamal F. Badr
12-Lipoxygenase Products Increase Monocyte: Endothelial Interactions	455	(8)
C. Hedrick
M. Kim
R. Natarajan
J. Nadler
LINOLEIC AND LINOLENIC ACIDS
Linoleic Acid Metabolites in Health and Disease	463	(8)
Michael R. Buchanan
Toxicity of Linoleic Acid Metabolites	471	(8)
Jessica F. Greene
Bruce D. Hammock
Dramatic Increase of Linoleic Acid Peroxidation Products by Aging, Atherosclerosis, and Rheumatoid Arthritis	479	(6)
Wolfgang Jira
Gerhard Spiteller
Modulation of Atherogenesis by Dietary Gamma-Linolenic Acid	485	(8)
Yang-Yi Fan
Kenneth S. Ramos
Robert S. Chapkin
The Selective Cytotoxicty of γ-Linolenic Acid (GLA) is Associated with Increased Oxidative Stress	493	(6)
Sujata Vartak
Mike E.C. Robbins
Arthur A. Spector
γ-Linolenic Acid (GLA)-Mediated Cytotoxicity in Human Prostate Cancer Cells	499	(6)
Mike Robbins
Kamran Ali
Ryan McCaw
Josalyn Olsen
Sujata Vartak
David Lubaroff
Five-Lipoxygenase Inhibitors Reduce Panc-1 Survival: Synergism of MK886 with Gamma Linolenic Acid	505	(8)
J.E. Harris
W.A. Alrefai
J. Meng
K. M. Anderson
ANANDAMIDE AND OTHER BIOACTIVE LIPIDS
Enzymological and Molecular Biological Studies on Anandamide Amidohydrolase	513	(6)
Natsuo Ueda
Kazuhisa Katayama
Yuko Kurahashi
Mitsujiro Suzuki
Hiroshi Suzuki
Shozo Yamamoto
Itsuo Katoh
Vincenzo Di Marzo
Luciano De Petrocellis
A Pathway for the Biosynthesis of Fatty Acid Amides	519	(8)
Kathleen A. Merkler
Laura E. Baumgart
Jodi L. DiBlassio
Uta Glufke
Lawrence King III
Kimberly Ritenour-Rodgers
John C. Vederas
Benjamin J. Wilcox
David J. Merkler
Investigation of Structural Analogs of Prostaglandin Amides for Binding to and Activation of CB1 and CB2 Cannabinoid Receptors in Rat Brain and Human Tonsils	527	(8)
Barbara A. Bergland
Daniel L. Boring
Allyn C. Howlett
Hepoxilin A3 is Metabolized into its ω-Hydroxy Metabolite by Human Neutrophils	535	(4)
Cecil R. Pace-Asciak
Denis Reynaud
Olga Rounova
Peter Demin
Kazimir K. Pivnitsky
Oxidation of Arachidonate Containing Glycerophospholipids in Intact Red Blood Cells and Red Blood Cell Membranes with Tert-Butylhydroperoxide	539	(8)
Tatsuji Nakamura
Lisa Hall
Robert C. Murphy
Cannabinoid Modulation of Neuronal Activity in Adult Rat Hippocampus	547	(8)
Paul Schweitzer
George R. Siggins
Samuel G. Madamba
APOPTOSIS
Cyclooxygenase-independent Induction of P21WAF-1/C1P1, Apoptosis and Differentiation by L-745,337 and Salicylate in HT-29 Colon Cancer Cells	555	(8)
Paola Patrignani
Giovanna Santini
Maria G. Sciulli
Rosanna Marinacci
Ornella Fusco
Luciana Spoletini
Clara Natoli
Antonio Procopio
Jacques Maclouf
Modulation of Cellular Proliferation and Induction of Apoptosis in a Human Lymphoma Cell Line After Treatment with Selective Lipoxygenase Inhibitors	563	(6)
Kenning M. Anderson
Frank G. Ondrey
Jules E. Harris
Mechanism of Peroxynitrite Induced Apoptosis in HL-60 Cells	569	(8)
King-Teh Lin
Ji-Yan Xue
Patrick Y-K. Wong
Central Role of Arachidonate 5-Lipoxygenase in the Regulation of Cell Growth and Apoptosis in Human Prostate Cancer Cells	577	(6)
Jagadananda Ghosh
Charles E. Myers
Role of Autocrine Motility Factor in a 12-Lipoxygenase Dependent Anti-Apoptotic Pathway	583	(10)
Keqin Tang
Daotai Nie
Kenneth V. Honn
CANCER PREVENTION AND TREATMENT
The Possible Involvement of 15-Lipoxygenase/Leukocyte Type 12-Lipoxygenase in Colorectal Carcinogenesis	593	(6)
Hideki Kamitani
Mark Geller
Thomas Eling
Induction of Leukotriene B4 Metabolism by Cancer Chemopreventive Agents	599	(8)
Thomas Primiano
Thomas W. Kensler
Michael A. Trush
Thomas R. Sutter
Intestinal Tumor Load in the Min/+ Mouse Model is Not Correlated with Eicosanoid Biosynthesis	607	(10)
Jay Whelan
Chun-Hung Chiu
Michael F. McEntee
12-Lipoxygenase Expression in Human Melanoma Cell Lines	617	(6)
Joszef Timar
Erzsebet Raso
Kenneth V. Honn
Wolfgang Hagmann
Platelet-Type 12-Lipoxygenase Regulates Angiogenesis in Human Prostate Carcinoma	623	(8)
Daotai Nie
Gilda G. Hillman
Timothy Geddes
Keqin Tang
Christopher Pierson
David J. Grignon
Kenneth V. Honn
Prostaglandin H Synthase and Lipoxygenase Mediated Activation of Xenobiotics in Platelets	631	(8)
Kyoung-Min Lim
Joo-Young Lee
Jung-Sun Kim
Jin-Ho Chung
Characterization of Two Spliced Variants of Human Phosphatidic Acid Phosphatase cDNAS that are Differentially Expressed in Normal and Tumor Cells	639	(8)
David W. Leung
Christopher K. Tompkins
Thayer White
Eicosapentaenoic Acid Alters Manganese Superoxide Dismutase Immunoreactive Protein Levels in Normal But Not Malignant Central Nervous System Derived Cells	647	(8)
Geoffrey D. Girnum
Larry W. Oberley
Steven A. Moore
Mike E.C. Robbins
Gamma Radiation and Release of Norepinephrine in the Hippocampus	655	(8)
Sathasiva B. Kandasamy
BIOACTIVE LIPIDS IN NON-MAMMALIAN CELLS
(3R)-Hydroxy-Oxylipins---A Novel Family of Oxygenated Polyenoic Fatty Acids of Fungal Origin	663	(6)
Santosh Nigam
Tankred Schewe
J. Lodewyk F. Kock
Eicosanoids in the Brain of Warm- and Cold-Acclimated Bullfrogs	669	(6)
Ceil A. Herman
Georgia Luczy-Bachman
Production of 3-Hydroxy Fatty Acids by the Yeast Dipodascopsis uninucleata. Biological Implications	675	(4)
J. Lodewyk F. Kock
Pierre Vener
Alfred Botha
Dennis J. Coetzee
Pieter W.J. vanWyk
Dandre P. Smith
Tankred Schewe
Santosh Nigam
Catalytic Properties of Linoleate Diol Synthase of the Fungas Gaeumannomyces graminis: A Comparison wit PGH Synthases	679	(8)
Ernst H. Oliw
Chao Su
Margareta Sahlin
Contributors	687	(6)
Index	693