Phospholipases | |
Phospholipase A2 Modification of Lipoproteins: Potential Effects on Atherogenesis | p. 3 |
Type IIA Secretory PLA2-Mediated Delayed PGE2 Biosynthesis is Regulated by the Products of the Cytosolic PLA2 | p. 9 |
Functional Coupling Between Phospholipase A2S and Cyclooxygenases in Immediate and Delayed Prostanoid Biosynthetic Pathways | p. 15 |
Cytosolic Phospholipase A2(Interacts with Microtubules | p. 21 |
Group IV Cytosolic Phospholipase A2 (PLA2) Function: Insights from the Knockout Mouse | p. 25 |
Investigation into the Involvement of Phospholipases A2 and MAP kinases in Modulation of AA Release and Cell Growth in A549 Cells | p. 33 |
Participation of Cytosolic Phospholipase A2 in Eicosanoid Generation by Mouse Bone Marrow-Derived Mast Cells | p. 41 |
Lipoxygenases and Cyclooxygenases | |
Analysis of Cyclooxygenase-Substrate Interactions Using Stereospecifically-Labeled Arachidonic Acids | p. 49 |
Sequence Determinants for the Positional Specificity of Lipoxygenases | p. 55 |
Regulation of Leukotriene C4 Synthase Gene Expression by SP1 and SP3 in Mononuclear Phagocytes | p. 61 |
PGG2, 11R-HPETE and 15R/S-HPETE are Formed from Different Conformers of Arachidonic Acid in the Prostaglandin Endoperoxide H Synthase-1 Cyclooxygenase Site | p. 67 |
Supression of Cyclooxygenase-2 Gene Transcription by Humulon | p. 73 |
Ishibition of 5-LO Activating Protein (FLAP) Activity Decreases Proteinuria in Streptozotocin (STZ)-Induced Diabetic Rats | p. 79 |
Inhibition of Ultraviolet Light B-Induced Cutaneous Inflammation by a Specific Cyclooxygenase-2-Inhibitor | p. 85 |
Cyclooxygenase-2 Expression and Activity are Induced by Amyloid-Beta 1-42 in Brain-Derived Cells | p. 93 |
Down-Regulation of 5-Lipoxygenase Activity and Leukotriene Production by Prolonged Exposure to Lipopolysaccharide | p. 101 |
Endothelial COX-2 Induction by Hypoxia Liberates 6-Keto-PGF1(,a Potent Epithelial Secretagogue | p. 107 |
Substrate Down Regulation of 12-Lipoxygenase in Human Platelets | p. 113 |
Calcium Binding to 5-Lipoxygenase | p. 117 |
Expression of Cyclooxygenase-2 in Human Bladder and Renal Cell Carcinoma | p. 123 |
Modulation of Cyclooxygenase-2 Expression by APC in HT-29 Human Colorectal Carcinoma Cells | p. 127 |
15-Lipoxygenase-1 Overexpression in Prostate Adenocarcinoma | p. 133 |
Characterization of Epidermal 12(S) and 12(R) Lipoxygenases | p. 147 |
Selective Inhibition of Cyclooxygenase-2 Attenuates Expression of Inflammation-Related Genes in CNS Injury | p. 155 |
Intracellular Activation and Induction of 12-Lipoxygenase in Mouse Peritoneal Macrophages | p. 161 |
Epidermis-Type Lipoxygenases | p. 165 |
Manganese Lipoxygenase has a Mononuclear Redox Center | p. 171 |
Cyclooxygenase-2 in Human Pathological Disease | p. 177 |
Leukotrienes and Lipoxins | |
Leukotriene D4-Induced Calcium Signaling in Human Intestinal Epithelial Cells | p. 187 |
Do Leukotrienes Increase Cell Viability in Human Intestinal Epithelial Cells? | p. 193 |
Aspirin-Triggered 15-EPI-Lipoxin A4 Biosynthesis in Rat Liver Cells | p. 199 |
Inhibiton of Allergen-Induced Eosinophil Migration by Lipoxin (LX)A4 and Aspirin-Triggered 15-EPI-LXA4 | p. 211 |
Anti-Leukotrienes as Novel Anti-Inflammatory Treatments in Asthma | p. 217 |
Lipoxin A4 and Aspirin-Triggered 15-EPI_Lipoxin A4 Modulate Adhesion Molecule Expression on Human Leukocytes in Whole Blood and Inhibit Neutrophil-Endothelial Cell Adhesion | p. 223 |
Mechanisms of Active Intestinal Inflammation and Potential Down-Regulation via Lipoxins | p. 229 |
Interactions Between 5-Oxo-ETE and Chemokines in Stimulating Eosinophils | p. 237 |
Enzymes in Eicosanoid Biosynthesis and Metabolism | |
Structure and Function of Human NAD+-Linked 15-Hydroxyprostaglandin Dehydrogenase | p. 245 |
Catalytic Properties of Purified Recombinant Anandamide Amidohydrolase | p. 251 |
Purification and Characterization of Membrane-Bound Prostaglandin E Synthase from Bovine Hearts | p. 257 |
cDNA Cloning and Mutagenesis Study of Liver-Type Prostaglandin F Synthase, and Identification of the Prostaglandin F Producing Cells in the Liver | p. 263 |
Determination of Cyclooxygenase and Arachidonic Acid Metabolites in Invasive Human Prostate Cancer Cells | p. 269 |
Effects of Overexpression of Prostacyclin Synthase in Vascular Smooth Muscle Cells | p. 275 |
Analysis of the Transcriptional Regulation of Mouse Prostacyclin Synthase Gene | p. 281 |
Characterization of Microsomal, Glutathione Dependent Prostaglandin E Synthase | p. 287 |
Receptors, Agonists and Antagonists | |
Activation-Dependent Internalization of the Human Prostacyclin Receptor | p. 295 |
The Design and Synthesis of Selective Prostaglandin Analogs as Bone Anabolic Agents for the Potential Treatment of Osteoporosis | p. 303 |
Leukotrienes and the Pulmonary Vascular Bed | p. 309 |
The Contraction of the Human Pulmonary Artery by LTC4 is Resistant to CysLT1 Antagonists and Counteracted by Prostacyclin Release | p. 315 |
Targeted Gene Disruption of the Prostaglandin E2 EP2 Receptor | p. 321 |
Ocular Hypotensive Activity of Prostaglandin F2(PGF20 Analogs with Neutral Substituents at Position 1 is Predicted by the Isolated Cat Iris Sphincter Smooth Muscle Prepararion but not Ca+ Signaling in Swiss 3T3 Cells | p. 327 |
Prostanoid FP Receptor-Mediated, Endothelium Dependent Vasodilatation and the Ocular Surface Hyperemic Response to PGF2( and Related Compounds | p. 331 |
Regulation of the CD36 Expression in Human Melanoma Cells | p. 337 |
Novel Eicosanoid Activators of PPAR( Formed by Raw 264.7 Macrophage Cultures | p. 343 |
Isoprostane Activation of the Nuclear Hormone Receptor PPAR | p. 351 |
In Vivo Chemotaxis using CHO Cells Expressing Human Leukotriene B4 Receptor | p. 357 |
Cancer and Inhibitors of Eicosanoid Biosynthesis | |
Mechanism of Inhibition of Novel COX-2 Inhibitors | p. 365 |
Chemopreventive Effects of Nimesulide, a Selective Cyclooxygenase-2 Inhibitor, Against PHIP-Induced Mammary Carcinogenesis | p. 371 |
Antitumor Effects of Piroxicam in Spontaneous Canine Invasive Urinary Bladder Cancer, a Relevant Model of Human Invasive Bladder Cancer | p. 377 |
Cannabimimetic Eicosanoids in Cancer and Inflammation: an Update | p. 381 |
Acetyl-11-Keto-(-Boswellic Acid (AKBA) is Cytotoxic for Meningioma Cells and Inhibits Phosphorilation of the Extracellular-Signal Regulated Kinase 1 and 2 | p. 387 |
Nitric Oxide, Cox-2 and Apostosis | |
Cyclooxygenase-2 Induction in Rat Spinal Cord Injury Mediated by Proinflammatory Tumor Necrosis Factor-( and Interleukin-1 | p. 397 |
Growth Stimulation and Epidermal Growth factor Receptor Induction in Cyclooxygenase-Overexpressing Human Colon Carcinoma Cells | p. 403 |
Relationship Between Apoptosis, Angiogenesis and Colon-26 Tumor Growth after Oral NSAID-Treatment | p. 409 |
Molecular Mechanisms of Prostate cancer Cell Death Triggered by Inhibition of Arachidonate 5-Lipoxygenase: Involvement of FAS Death Receptor-Mediate Signals | p. 415 |
Induction of Apoptosis in Mouse T Cells upon Peroxisome Proliferator-Activated Receptor Gamma (PPAR0 Binding | p. 421 |
Nitration of Cytochrome C by Peroxynitrite: a Putative Antiapoptotic Pathway Mediated by Prostaglandin H2 Synthase (PGHS) and Nitric Oxide (NO) Synthase | p. 427 |
Apoptosis in Vascular Smooth Muscle Accompanied by Increases in Arachidonic Acid | p. 433 |
Sphingolipids in Vascular Biology | p. 439 |
Cyclooxygenase-2: A Molecular Target for Chemoprevention of Epithelial Tumors of Skin and Colon | p. 445 |
Signaling Pathways | |
MK 886 Functions as a Radiomimetic Agent: Genomic Responses Related to Oxidative Stress, the Cell Cycle, Proliferation and Programmed Cell Death in PANC-1 Cells | p. 451 |
LPS-Induced Synthesis and Release of PGE2 in Liver Macrophages: Regulation by cPLA2, COX-1, COX-2, and PGE2 synthase | p. 457 |
13(S)-HpODE Modulates Mitogenic Signal Transduction Through Enhancing the Phosphorylation and Association of the EGF Receptor with the Tyrosine Phosphatase SHP-2 | p. 463 |
KU 70/80 Lupus Autoantigen is the Transcription Factor Induced by Interleukins (IL)-13 and -4 Leading to Induction of 15-Lipoxygenase (15-LO) in Human Cells | p. 469 |
Divergence in Intracellular Signaling Between Interleukin-4 (IL-4) and IL-13 in Human Cells Localizes to Monomeric/Dimeric Expression of a Transcription Factor, The Lupus Autoantigen 70/80, Induced by Both Cytokins | p. 483 |
Role of Phosphatidylethanolamine in G Protein Coupled Receptor-Associated Signal Transduction | p. 491 |
The p21-Activated Protein Kinases (PAKs) Receive and Integrate Messages from a Variety of Signaling Pathways | p. 497 |
Signaling Pathways for TNF(-Induced COX-2 Expression: Mediation Through Map Kinases and NFkB, and Inhibition by Certain Nonsteroidal Anti-Inflammatory Drugs | p. 503 |
12(S)-HETE, Pleiotropic Functions, Multiple Signaling Pathways | p. 509 |
Hydroxy Fatty Acids, Lipids and Isoeicosanoids | |
Formation of Novel D-Ring and E-Ring Isoprostane-Like Compounds (D4 /E4-Neuroprostanes) in vivo from Docosahexaenoic Acid | p. 519 |
Regulation of Cell-Substrate Adhesion by the Lypoxygenase and Cyclooxygenase Branches of Arachidonic Acid Metabolism | p. 525 |
Development of Enzyme Immunoassays for 5,6-, 8,9-, 11,12- and 14,15-EETS and the Corresponding DHETS | p. 531 |
Enzyme Immunoassays for 15-F2t Isoprostane-M, an Urinary Biomarker for Oxidant Stress | p. 537 |
Biphasic Regulation of Leukocyte Trafficking by Lipoxins | p. 543 |
Pantothenic Acid: An Organ-Specific Pro-Oxidant Vitamin-Brain and Liver Neuroprostane Levels in Rats Fed a Pantothenic Acid-Deficient Diet | p. 551 |
Linoleate Diol Synthase and PHG Synthase n A New Gene Family of Fatty Acid Heme Dioxygenases? | p. 557 |
Eicosanoids Regulation of Transcription Factors in PC-3 Prostate Cancer Cells | p. 563 |
Knock-Out Animal Models | |
Non-Prostaglandin Effects of Aspirin III and Salicylate: Inhibition of Integrin-Dependent Human Neutrophil Aggregation and Inflammation in COX-2 and NFKB (P105)-Knockout Mice | p. 571 |
Dietary EPA Reduces Tumor Load in Apc Min/+ Mice by Altering Arachidonic Acid Metabolism, But Conjugated Linoleic Acid, Gamma- and Alpha-Linoleic Acids Have No Effect | p. 579 |
The Regulation of Cyclooxygenase-1 and -2 in Knockout Cells and Mice | p. 585 |
Prostanoids in Health and Disease; Lessons from Receptor-Knockout Mice | p. 593 |
Contributors | p. 599 |
Index | p. 621 |
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