Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 5

by Honn, Kenneth V.; Marnett, Lawrence J.; Nigam, Santosh; Dennis, Edward A.; Serhan, Charles

• ISBN13: 9780306472831
• ISBN10: 030647283X
• Edition: 1st
• Format: Hardcover
• Copyright: 2003-02-28
• Publisher: Kluwer Academic Pub

Summary

This volume represents a collection of manuscripts dealing with the roles and actions of lipid mediators and their impact on human physiology and disease pathogenesis. In particular these contributions focus on cancer, inflammation and cardiovascular disease. The most recent advances in the formation and actions of lipid mediators is discussed at the molecular and cellular level. The synthesis of novel inhibitors is discussed relevant to their potential impact on cancer and inflammatory disease therapy. In addition to the "classical" lipid mediators, this volume contains presentations of exciting new developments in anandamides, nitric oxide and isoeicosanoids. The data and concepts presented in this volume should be of interest to both clinicians and basic researchers in the fields of cancer and inflammation.

Table of Contents

Phospholipases
Phospholipase A2 Modification of Lipoproteins: Potential Effects on Atherogenesis	p. 3
Type IIA Secretory PLA2-Mediated Delayed PGE2 Biosynthesis is Regulated by the Products of the Cytosolic PLA2	p. 9
Functional Coupling Between Phospholipase A2S and Cyclooxygenases in Immediate and Delayed Prostanoid Biosynthetic Pathways	p. 15
Cytosolic Phospholipase A2(Interacts with Microtubules	p. 21
Group IV Cytosolic Phospholipase A2 (PLA2) Function: Insights from the Knockout Mouse	p. 25
Investigation into the Involvement of Phospholipases A2 and MAP kinases in Modulation of AA Release and Cell Growth in A549 Cells	p. 33
Participation of Cytosolic Phospholipase A2 in Eicosanoid Generation by Mouse Bone Marrow-Derived Mast Cells	p. 41
Lipoxygenases and Cyclooxygenases
Analysis of Cyclooxygenase-Substrate Interactions Using Stereospecifically-Labeled Arachidonic Acids	p. 49
Sequence Determinants for the Positional Specificity of Lipoxygenases	p. 55
Regulation of Leukotriene C4 Synthase Gene Expression by SP1 and SP3 in Mononuclear Phagocytes	p. 61
PGG2, 11R-HPETE and 15R/S-HPETE are Formed from Different Conformers of Arachidonic Acid in the Prostaglandin Endoperoxide H Synthase-1 Cyclooxygenase Site	p. 67
Supression of Cyclooxygenase-2 Gene Transcription by Humulon	p. 73
Ishibition of 5-LO Activating Protein (FLAP) Activity Decreases Proteinuria in Streptozotocin (STZ)-Induced Diabetic Rats	p. 79
Inhibition of Ultraviolet Light B-Induced Cutaneous Inflammation by a Specific Cyclooxygenase-2-Inhibitor	p. 85
Cyclooxygenase-2 Expression and Activity are Induced by Amyloid-Beta 1-42 in Brain-Derived Cells	p. 93
Down-Regulation of 5-Lipoxygenase Activity and Leukotriene Production by Prolonged Exposure to Lipopolysaccharide	p. 101
Endothelial COX-2 Induction by Hypoxia Liberates 6-Keto-PGF1(,a Potent Epithelial Secretagogue	p. 107
Substrate Down Regulation of 12-Lipoxygenase in Human Platelets	p. 113
Calcium Binding to 5-Lipoxygenase	p. 117
Expression of Cyclooxygenase-2 in Human Bladder and Renal Cell Carcinoma	p. 123
Modulation of Cyclooxygenase-2 Expression by APC in HT-29 Human Colorectal Carcinoma Cells	p. 127
15-Lipoxygenase-1 Overexpression in Prostate Adenocarcinoma	p. 133
Characterization of Epidermal 12(S) and 12(R) Lipoxygenases	p. 147
Selective Inhibition of Cyclooxygenase-2 Attenuates Expression of Inflammation-Related Genes in CNS Injury	p. 155
Intracellular Activation and Induction of 12-Lipoxygenase in Mouse Peritoneal Macrophages	p. 161
Epidermis-Type Lipoxygenases	p. 165
Manganese Lipoxygenase has a Mononuclear Redox Center	p. 171
Cyclooxygenase-2 in Human Pathological Disease	p. 177
Leukotrienes and Lipoxins
Leukotriene D4-Induced Calcium Signaling in Human Intestinal Epithelial Cells	p. 187
Do Leukotrienes Increase Cell Viability in Human Intestinal Epithelial Cells?	p. 193
Aspirin-Triggered 15-EPI-Lipoxin A4 Biosynthesis in Rat Liver Cells	p. 199
Inhibiton of Allergen-Induced Eosinophil Migration by Lipoxin (LX)A4 and Aspirin-Triggered 15-EPI-LXA4	p. 211
Anti-Leukotrienes as Novel Anti-Inflammatory Treatments in Asthma	p. 217
Lipoxin A4 and Aspirin-Triggered 15-EPI_Lipoxin A4 Modulate Adhesion Molecule Expression on Human Leukocytes in Whole Blood and Inhibit Neutrophil-Endothelial Cell Adhesion	p. 223
Mechanisms of Active Intestinal Inflammation and Potential Down-Regulation via Lipoxins	p. 229
Interactions Between 5-Oxo-ETE and Chemokines in Stimulating Eosinophils	p. 237
Enzymes in Eicosanoid Biosynthesis and Metabolism
Structure and Function of Human NAD+-Linked 15-Hydroxyprostaglandin Dehydrogenase	p. 245
Catalytic Properties of Purified Recombinant Anandamide Amidohydrolase	p. 251
Purification and Characterization of Membrane-Bound Prostaglandin E Synthase from Bovine Hearts	p. 257
cDNA Cloning and Mutagenesis Study of Liver-Type Prostaglandin F Synthase, and Identification of the Prostaglandin F Producing Cells in the Liver	p. 263
Determination of Cyclooxygenase and Arachidonic Acid Metabolites in Invasive Human Prostate Cancer Cells	p. 269
Effects of Overexpression of Prostacyclin Synthase in Vascular Smooth Muscle Cells	p. 275
Analysis of the Transcriptional Regulation of Mouse Prostacyclin Synthase Gene	p. 281
Characterization of Microsomal, Glutathione Dependent Prostaglandin E Synthase	p. 287
Receptors, Agonists and Antagonists
Activation-Dependent Internalization of the Human Prostacyclin Receptor	p. 295
The Design and Synthesis of Selective Prostaglandin Analogs as Bone Anabolic Agents for the Potential Treatment of Osteoporosis	p. 303
Leukotrienes and the Pulmonary Vascular Bed	p. 309
The Contraction of the Human Pulmonary Artery by LTC4 is Resistant to CysLT1 Antagonists and Counteracted by Prostacyclin Release	p. 315
Targeted Gene Disruption of the Prostaglandin E2 EP2 Receptor	p. 321
Ocular Hypotensive Activity of Prostaglandin F2(PGF20 Analogs with Neutral Substituents at Position 1 is Predicted by the Isolated Cat Iris Sphincter Smooth Muscle Prepararion but not Ca+ Signaling in Swiss 3T3 Cells	p. 327
Prostanoid FP Receptor-Mediated, Endothelium Dependent Vasodilatation and the Ocular Surface Hyperemic Response to PGF2( and Related Compounds	p. 331
Regulation of the CD36 Expression in Human Melanoma Cells	p. 337
Novel Eicosanoid Activators of PPAR( Formed by Raw 264.7 Macrophage Cultures	p. 343
Isoprostane Activation of the Nuclear Hormone Receptor PPAR	p. 351
In Vivo Chemotaxis using CHO Cells Expressing Human Leukotriene B4 Receptor	p. 357
Cancer and Inhibitors of Eicosanoid Biosynthesis
Mechanism of Inhibition of Novel COX-2 Inhibitors	p. 365
Chemopreventive Effects of Nimesulide, a Selective Cyclooxygenase-2 Inhibitor, Against PHIP-Induced Mammary Carcinogenesis	p. 371
Antitumor Effects of Piroxicam in Spontaneous Canine Invasive Urinary Bladder Cancer, a Relevant Model of Human Invasive Bladder Cancer	p. 377
Cannabimimetic Eicosanoids in Cancer and Inflammation: an Update	p. 381
Acetyl-11-Keto-(-Boswellic Acid (AKBA) is Cytotoxic for Meningioma Cells and Inhibits Phosphorilation of the Extracellular-Signal Regulated Kinase 1 and 2	p. 387
Nitric Oxide, Cox-2 and Apostosis
Cyclooxygenase-2 Induction in Rat Spinal Cord Injury Mediated by Proinflammatory Tumor Necrosis Factor-( and Interleukin-1	p. 397
Growth Stimulation and Epidermal Growth factor Receptor Induction in Cyclooxygenase-Overexpressing Human Colon Carcinoma Cells	p. 403
Relationship Between Apoptosis, Angiogenesis and Colon-26 Tumor Growth after Oral NSAID-Treatment	p. 409
Molecular Mechanisms of Prostate cancer Cell Death Triggered by Inhibition of Arachidonate 5-Lipoxygenase: Involvement of FAS Death Receptor-Mediate Signals	p. 415
Induction of Apoptosis in Mouse T Cells upon Peroxisome Proliferator-Activated Receptor Gamma (PPAR0 Binding	p. 421
Nitration of Cytochrome C by Peroxynitrite: a Putative Antiapoptotic Pathway Mediated by Prostaglandin H2 Synthase (PGHS) and Nitric Oxide (NO) Synthase	p. 427
Apoptosis in Vascular Smooth Muscle Accompanied by Increases in Arachidonic Acid	p. 433
Sphingolipids in Vascular Biology	p. 439
Cyclooxygenase-2: A Molecular Target for Chemoprevention of Epithelial Tumors of Skin and Colon	p. 445
Signaling Pathways
MK 886 Functions as a Radiomimetic Agent: Genomic Responses Related to Oxidative Stress, the Cell Cycle, Proliferation and Programmed Cell Death in PANC-1 Cells	p. 451
LPS-Induced Synthesis and Release of PGE2 in Liver Macrophages: Regulation by cPLA2, COX-1, COX-2, and PGE2 synthase	p. 457
13(S)-HpODE Modulates Mitogenic Signal Transduction Through Enhancing the Phosphorylation and Association of the EGF Receptor with the Tyrosine Phosphatase SHP-2	p. 463
KU 70/80 Lupus Autoantigen is the Transcription Factor Induced by Interleukins (IL)-13 and -4 Leading to Induction of 15-Lipoxygenase (15-LO) in Human Cells	p. 469
Divergence in Intracellular Signaling Between Interleukin-4 (IL-4) and IL-13 in Human Cells Localizes to Monomeric/Dimeric Expression of a Transcription Factor, The Lupus Autoantigen 70/80, Induced by Both Cytokins	p. 483
Role of Phosphatidylethanolamine in G Protein Coupled Receptor-Associated Signal Transduction	p. 491
The p21-Activated Protein Kinases (PAKs) Receive and Integrate Messages from a Variety of Signaling Pathways	p. 497
Signaling Pathways for TNF(-Induced COX-2 Expression: Mediation Through Map Kinases and NFkB, and Inhibition by Certain Nonsteroidal Anti-Inflammatory Drugs	p. 503
12(S)-HETE, Pleiotropic Functions, Multiple Signaling Pathways	p. 509
Hydroxy Fatty Acids, Lipids and Isoeicosanoids
Formation of Novel D-Ring and E-Ring Isoprostane-Like Compounds (D4 /E4-Neuroprostanes) in vivo from Docosahexaenoic Acid	p. 519
Regulation of Cell-Substrate Adhesion by the Lypoxygenase and Cyclooxygenase Branches of Arachidonic Acid Metabolism	p. 525
Development of Enzyme Immunoassays for 5,6-, 8,9-, 11,12- and 14,15-EETS and the Corresponding DHETS	p. 531
Enzyme Immunoassays for 15-F2t Isoprostane-M, an Urinary Biomarker for Oxidant Stress	p. 537
Biphasic Regulation of Leukocyte Trafficking by Lipoxins	p. 543
Pantothenic Acid: An Organ-Specific Pro-Oxidant Vitamin-Brain and Liver Neuroprostane Levels in Rats Fed a Pantothenic Acid-Deficient Diet	p. 551
Linoleate Diol Synthase and PHG Synthase n A New Gene Family of Fatty Acid Heme Dioxygenases?	p. 557
Eicosanoids Regulation of Transcription Factors in PC-3 Prostate Cancer Cells	p. 563
Knock-Out Animal Models
Non-Prostaglandin Effects of Aspirin III and Salicylate: Inhibition of Integrin-Dependent Human Neutrophil Aggregation and Inflammation in COX-2 and NFKB (P105)-Knockout Mice	p. 571
Dietary EPA Reduces Tumor Load in Apc Min/+ Mice by Altering Arachidonic Acid Metabolism, But Conjugated Linoleic Acid, Gamma- and Alpha-Linoleic Acids Have No Effect	p. 579
The Regulation of Cyclooxygenase-1 and -2 in Knockout Cells and Mice	p. 585
Prostanoids in Health and Disease; Lessons from Receptor-Knockout Mice	p. 593
Contributors	p. 599
Index	p. 621
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