Electrical Diseases of the Heart : Genetics, Mechanisms, Treatment, Prevention

by Gussak, Ihor; Antzelevitch, Charles; Wilde, Arthur A. M. (CON); Friedman, Paul A., M.D. (CON); Ackerman, Michael J. (CON)

• ISBN13: 9781846288531
• ISBN10: 1846288533
• Edition: 1st
• Format: Hardcover
• Copyright: 2007-11-30
• Publisher: Springer Verlag

Summary

This book provides a unique contemporary and succinct distillation of the current status of recently delineated electrical diseases of the heart, emphasizing their common and diverse clinical features. The latest developments in the field of experimental and clinical cardiac electrophysiology, genetics, pharmacology and interventional therapies of various clinical arrhythmogenic entities are featured and discussed in terms of recent advances in basic and clinical science. The book is divided into seven major parts. Each part consists of chapters (total of 64) dealing with related topics.

Table of Contents

Basic Foundations of Normal and Abnormal Cardiac Electrical Activity
The Past and Promise of Basic Cardiac Electrophysiology	p. 3
Basic Physiology of Ion Channel Function	p. 11
Developmental Aspects of the Electrophysiology of the Heart: Function Follows Form	p. 24
Anatomic and Histopathological Characteristics of the Conductive Tissues of the Heart	p. 37
Neural Regulation of the Heart in Health and Disease	p. 52
Mechanisms of Cardiac Arrhythmia	p. 65
Mechanisms of Action of Antiarrhythmic Drugs	p. 133
Mechanoelectrical Interactions and Their Role in Electrical Function of the Heart	p. 145
The Role of Cellular Sodium and Calcium Loading in Cardiac Energetics and Arrhythmogeneis: Contribution of the Late Sodium Current	p. 161
Sodium Ion Channelopathies	p. 170
L-Type Calcium Channel Disease	p. 187
K[superscript +] Channelopathies (I[subscript Ks] and I[subscript Kr])	p. 194
Channelopathies of Cardiac Inwardly Rectifying Potassium Channels	p. 207
Calcium Release Channels (Ryanodine Receptors) and Arrhythmogenesis	p. 218
Caveolae and Arrhythmogenesis	p. 232
Senescence and Arrhythmogenesis	p. 247
Comparisons of Substrates Responsible for Atrial Versus Ventricular Fibrillation	p. 261
Single Nucleotide Polymorphisms in Health and Cardiac Disease	p. 281
Electrophysiological Remodeling in Dilated Cardiomyopathy and Heart Failure	p. 290
Ventricular Electrical Remodeling in Compensated Cardiac Hypertrophy	p. 305
Physiological and Other Biological Pacemakers	p. 316
Clinical Rhythmology: Diagnostic Methods and Tools
Diagnostic Electrocardiography	p. 331
Ambulatory Monitoring (Holter, Event Recorders, External, and Implantable Loop Recorders and Wireless Technology)	p. 344
Signal Averaged Electrocardiogram	p. 353
Heart Rate Variability: Measurements and Risk Stratification	p. 365
Surface Mapping and Magnetoelectrocardiography	p. 379
Microvolt T Wave Alternans: Mechanisms and Implications for Prediction of Sudden Cardiac Death	p. 394
Invasive Electrophysiologic Testing: Role in Sudden Death Prediction	p. 409
Provocative Testing in Inherited Arrhythmias	p. 424
Novel Predictors of Sudden Cardiac Death	p. 434
Genetic Testing	p. 444
Heritable Cardiac Channelopathies, Primary Electrical Diseases, and Clinical Syndromes
Celebrating the Challenge of Cardiac Arrhythmias	p. 461
Congenital Long QT Syndrome	p. 462
Brugada Syndrome: Clinical and Genetic Aspects	p. 483
Brugada Syndrome: Cellular Mechanisms and Approaches to Therapy	p. 500
Catecholaminergic Polymorphic Ventricular Tachycardia	p. 536
Andersen-Tawil and Timothy Syndromes	p. 545
Short QT Syndrome	p. 554
Progressive Cardiac Conduction Disease	p. 564
Familial Atrial Fibrillation and Standstill	p. 577
Idiopathic Ventricular Fibrillation	p. 588
Secondary Hereditary Electrical Diseases and Clinical Syndromes
Cardiac Remodeling	p. 607
Arrhythmogenic Malignancies in Hypertrophic Cardiomyopathy	p. 610
Sudden Death in Dilated Cardiomyopathy and Skeletal Myopathies	p. 627
Ventricular Arrhythmias in Right Ventricular Dysplasia/Cardiomyopathy	p. 643
The Wolff-Parkinson-White Syndrome and the Risk of Sudden Death	p. 654
Iatrongenic (Drug-Induced) Cardiac Channelopathies and Sudden Cardiac Death
Drug-Induced Enhanced Risk for Sudden Cardiac Death in Clinical Practice, Clinical Research, and Drug Development	p. 673
Pharmacogenomics in Drug Development and Clinical Research	p. 677
Mechanisms of Drug-Induced Cardiac Toxicity	p. 691
Acquired (Drug-Induced) Long QT Syndrome	p. 705
Acquired Form of Brugada Syndrome	p. 719
Treatment Modalities
Treatment Modalities	p. 731
Clinical Role of Antiarrhythmic Drugs in the Prevention of Sudden Death	p. 733
Nonantiarrhythmic Drugs in Sudden Death Prevention	p. 760
The Implantable Cardioverter Defibrillator: Technical and Clinical Considerations	p. 772
Beyond Sudden Death Prevention: Minimizing Implantable Cardioverter Defibrillator Shocks and Morbidity and Optimizing Efficacy	p. 781
Pacing and Cardiac Resynchronization	p. 801
Device Therapy for Remote Patient Management	p. 809
Catheter Ablation of Ventricular Tachycardia and Fibrillation	p. 82ä
Surgical Treatment of Atrial Fibrillation	p. 83ä
Risk Stratification and Prevention of Sudden Cardiac Death in Acquired Clinical Conditions
Screening for Risk of Sudden Cardiac Death	p. 851
Clinical Trials in Sudden Cardiac Death Prevention: Principles and Endpoints	p. 853
Risk Stratification for Sudden Death in Patients with Coronary Artery Disease	p. 858
Heart Failure and Sudden Death	p. 873
Neurological Conditions and Sudden Death	p. 888
Obstructive Sleep Apnea and Sudden Death	p. 898
Sudden Cardiac Death in Athletes	p. 911
Sudden Cardiac Death in Infancy: Focus on Prolonged Repolarization	p. 924
Sudden Cardiac Death in Kidney Diseases	p. 934
Table of Contents provided by Blackwell. All Rights Reserved.