Two children die of a disease thought to be nonexistent. Within hours, Thoroughbreds at the legendary Churchill Downs are dying of a unidentified virus. Noted virologist Jack Bryne discovers that the deaths bear uncanny similarities to the Fifth and Sixth Plagues described in Exodus, and every month another more catastrophic plague occurs.
Soon Bryne's worldwide medical computer network. ProMED, is invaded by the power behind the horrors -- a morbidly brilliant serial killer with a dangerously sophisticated knowledge of toxins and an obsession with biblical retribution.
Bryne, himself now considered a suspect by the FBI, must stop this maniac in time before the worst comes...The Eleventh Plague.