Endocrine Aspects of Successful Aging

by Chanson, P.; Lamberts, S.; Epelbaum, J.; Christen, Y.

• ISBN13: 9783540405733
• ISBN10: 3540405739
• Format: Hardcover
• Copyright: 2004-01-12
• Publisher: Springer Verlag

Summary

At the beginning of the 20th century, life expectancy at birth in North America and Western Europe was around 50 years of age. Nowadays, women have gained more than 30 years of age and men are trailing closer. However, according to several sociologists such as Louis Chauvel, the notion of a "greying society" is not entirely adequate since aging people are physically and socially younger and more active for a longer time. Of course, the other side of the medal is to tackle the challenge of preventing age-associated chronic diseases. In this book the extensive field of research on neuroendocrine aging has been reviewed. Aging is one of the most complex biological processes determined by the interactions between genetic and environmental factors.

Table of Contents

Regulation of C. elegans Life Span by Insulin-Like Signaling	1	(18)
G. Ruvkun
IGF-1 and Insulin Signaling in the Control of Longevity	19	(16)
A. Bartke
J. Kopchick
F. Dominici
D. Turyn
IGF-1 Receptors in Mammalian Longevity: Less is More	35	(14)
M. Holzenberger
IGF-1 Gene Polymorphism and Disease in the Elderly	49	(14)
J.A.M.J.L. Janssen
S.W.J. Lamberts
Polymorphisms and Male Ageing	63	(26)
M. Jiang
I. Huhtaniemi
Age-Related Changes in the Regulation of the Hypothalamic-Pituitary Adrenal Axis: the Role of Personality Variables	89	(12)
J.C. Pruessner
C. Lord
R. Renwick
M. Meaney
S. Lupien
Aging White Matter and Cognitive Decline: A Role for Steroids	101	(28)
M. Schumacher
C. Ibanez
F. Robert
L.M. Garcia-Segura
R. Franklin
R. Melcangi
How Do Changes in the GH/IGF-1 Status of the Elderly -- Whether Occurring Naturally, Pathologically or Therapeutically Induced -- Impact Their Lives?	129	(20)
S.K. AA. Shakoor
A.A. Toogood
S.M. Shalet
Estrogen and Cognitive Functioning in Women	149	(8)
B.B. Sherwin
Genetic Polymorphisms and Age-Related Diseases: the Example of Osteoporosis	157	(8)
A.G. Uitterlinden
H. A. P. Pols
Are Estrogens Protective or Risk Factors in the Brain? Insights Derived from Animal Models	165	(10)
P.M. Wise
D.B. Dubal
Testosterone Supplementation and Aging-Associated Sarcopenia	175	(16)
S. Bhasin
The Long Thread of GFAP in Aging, Steroids, and Synaptic Plasticity	191	(16)
C.E. Finch
T.E. Morgan
I. Rozovsky
M. Wei
Circadian Rhythmicity and Aging: The Molecular Basis of Oscillatory Gene Expression	207	(10)
P. Sassone-Corsi
Prediction of Death in the Elderly Men: Endocrine Factors	217	(12)
A.W. van den Beld
S.W.J. Lamberts
Subject Index	229