Endocrine Disruption Biological Bases for Health Effects in Wildlife and Humans

by Norris, David O.; Carr, James A.

• ISBN13: 9780195137491
• ISBN10: 0195137493
• Format: Hardcover
• Copyright: 2005-09-22
• Publisher: Oxford University Press

Summary

This book addresses the biological effects of the reasonably large number of classes of compounds that have been recognized as endocrine disrupters. These compounds have been found to persist as pollutants in the environment, and have been blamed for causing developmental disorders and/or fertility problems in fish, amphibians, reptiles, birds, and possibly humans. This book presents the relevant fundamentals of the endocrine systems of animals and humans, the toxicology, developmental toxicology, ecology, and risk assessment methods, and lays out the current state of understanding for the whole field, organized by the classes of compounds that have been identified as endocrine disrupters.

Table of Contents

Contributors	xiii
Part I. Vertebrate Chemical Regulation
Introduction to Endocrinology	3	(25)
David O. Norris
James A. Carr
Hormone Action on Receptors	28	(30)
Miles Orchinik
Catherine Propper
The Hypothalamus-Pituitary Axis	58	(29)
James A. Carr
David O. Norris
The Thyroid Gland	87	(24)
James A. Carr
David O. Norris
The Adrenal Glands	111	(24)
James A. Carr
David O. Norris
The Gonads	135	(26)
James A. Carr
David O. Norris
Part II. Toxicology and Risk Assessment
Introduction to Part II	155	(6)
Ernest E. Smith
James A. Carr
David O. Norris
Introduction to the Science of Toxicology	161	(27)
Richard L. Dickerson
Ernest E. Smith
Probabilistic Risk Assessment	188	(14)
Kenneth R. Dixon
Clyde F. Martin
Fish and Wildlife as Sentinels of Environmental Contamination	202	(25)
Lynn Frame
Richard L. Dickerson
Part III. Representative EDCs in Animals
Introduction to Part III	225	(2)
James A. Carr
David O. Norris
Polychlorinated Dibenzo-p-Dioxins: Potential Mechanisms and Risk as Endocrine Disruptors	227	(18)
Mary K. Walker
Toxicology of PCBs and Related Compounds	245	(87)
John P. Giesy
K. Kannan
Alan L. Blankenship
Paul D. Jones
J. L. Newsted
DDT and Its Analogues: New Insights into Their Endocrine-Disrupting Effects on Wildlife	332	(24)
Louis J. Guillette, Jr.
Stefan A.E. Kools
Mark P. Gunderson
Dieldrich S. Bermudez
Heavy Metals	356	(19)
Alice Hontela
Alexandra Lacroix
Effects of Alkylphenolic Compounds on Wildlife	375	(15)
Werner Kloas
Endocrine-Active Phytochemicals: Environmental Signaling Context and Mechanisms	390	(34)
Alan M. Vajda
David O. Norris
Triazines	424	(27)
Timothy S. Gross
R. Heath Rauschenberger
Appendices	451	(12)
Index	463

Excerpts

"This book addresses the biological effects of the large number of classes of compounds that have been recognized as endocrine disruptors. These compounds persist as pollutants in the environment and have been linked to a number of fertility and developmental disorders in fish, amphibians, reptiles, birds, and humans. Norris and Carr present a well-rounded and cohesive examination of the endocrinology, toxicology, and ecology related to these phenomena. They lay out the current state of understanding of the whole field, and include a final section organized by the classes of compounds that have been identified as endocrine disruptors." "Endocrinologists, toxicologists, and ecologists, as well as environmentalists, politicians, and government officials - will find that this book covers the fundamentals of unfamiliar areas of experience. This is intended also to be a useful primer for students interested in a comprehensive introduction to the subject. Endocrine Disruption guides readers to a better understanding of the interrelationships and complex problems involved in assessing and regulating the health of wildlife and humans."--BOOK JACKET.