Endocrine Toxicology, Second Edition

by Thomas; John A.

• ISBN13: 9781560326137
• ISBN10: 1560326131
• Edition: 2nd
• Format: Hardcover
• Copyright: 1997-01-29
• Publisher: CRC Press

Summary

This text presents a range of topics from the molecular events surrounding hormone actions to epidemiologic studies of the effects of environmental and occupational chemicals on reproductive organs. The endocrine systems covered include the adrenal cortex, thyroid and parathyroid, gonads, and the endocrine pancreas. Of particular importance are the chapters covering the general characteristics of the estrogen receptors and the androgen receptors. The book also describes some of the underlying toxic mechanisms involving pancreatic B cells and metal-induced changes in male sex accessory glands.

Table of Contents

Contributing Authors
Preface
Introduction
Chemically-Induced Injury of the Parathyroid Gland: Pathophysiology and Mechanistic Considerations	p. 1
Physiology of the Thyroid Gland and Agents Affecting Its Secretion	p. 43
Chemically-Induced Changes in the Thyroid	p. 69
Toxicology of the Adrenal Cortex: Role of Metabolic Activation	p. 81
Chemically-Induced Lesions in the Adrenal Cortex	p. 115
Steroid Receptors	p. 133
Xenoestrogens and Estrogen Receptor Action	p. 181
Cellular and Molecular Effects of Androgenic-Anabolic Steroids	p. 213
Role of Cadmium in the Etiology of Cancer of the Prostate	p. 227
Actions of Chemicals and Other Factors on Leydig Cell Growth and Proliferation	p. 245
Toxic Effects of Cyproheptadine and Its Analogs in Insulin-Producing Cells	p. 257
Epidemiologic Evidence for Toxic Effects of Occupational and Environmental Chemicals on the Testes	p. 287
Subject Index	p. 327
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