Endocrine Toxicology, Third Edition

by Eldridge; J. Charles

• ISBN13: 9781420093094
• ISBN10: 1420093096
• Edition: 3rd
• Format: Hardcover
• Copyright: 2010-02-15
• Publisher: CRC Press

Summary

Examines endocrine toxicology's increased importance in environmental safety issues due to legislative directives established over the past ten years. With contributions by international experts in academia, chemical manufacturing, government research laboratories, regulatory agencies, and private consulting, this guide explores the potentially damaging influence of environmental agents on the endocrine system.

Table of Contents

Preface	p. vii
Contributors	p. xi
Testing and Methods
The U.S. EPA's Tier 1 Screening Battery for Endocrine Disruptor Compounds	p. 1
The Effects of Endocrine Disrupting Chemicals on Pubertal Development in the Rat: Use of the EDSP Pubertal Assays as a Screen	p. 27
Male Reproductive Endpoints and the Rodent Hershberger Assay	p. 82
Overview of USEPA Tests with Aquatic Vertebrates for Detecting and Assessing Endocrine Disrupting Chemicals	p. 102
Molecular Toxicology
Modulation of Estrogen Receptor Signaling by Endocrine Disrupting Chemicals	p. 131
Androgen Receptor Binding and Transactivation Assays Identify Environmental Chemicals as Endocrine Disruptors	p. 149
Structure-Activity Modeling of Endocrine Disruptors	p. 175
Aryl Hydrocarbon Receptor Ligands: Toxic, Biochemical, and Therapeutic Effects	p. 189
Mammalian Effects
The Impact of Centrally Acting Pesticidal/Environmental Toxicants on the Neuroendocrine Regulation of Reproductive Function in the Female Rodent: Relevance to Human Reproductive Risk Assessment	p. 210
Time-Dependent Embryotoxicity of the Endogenous Luteolysin Prostaglandin F2¿ in Ruminants	p. 240
Metal Toxicity in Mammalian Reproduction	p. 256
Wildlife Effects
Overview of Endocrine Disruptor Ecotoxicity in Wildlife	p. 280
Avian Endocrine Toxicology	p. 313
Endocrine-Disrupting Compounds in Aquatic Ecosystems	p. 324
The Hypothalamic-Pituitary-Gonadal Axis in Anuran Amphibians	p. 352
Policy and Management
Impact of Endocrine Disruptor Policies and Regulations	p. 365
Impact of Endocrine Disrupting Compounds to the Water Industry	p. 380
Index	p. 397
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