Endosomes and Lysosomes: A Dynamic Relationship

by Storrie; Murphy

• ISBN13: 9781559383622
• ISBN10: 1559383623
• Format: Hardcover
• Copyright: 1993-06-01
• Publisher: Elsevier Science

Summary

The intent in initiating this volume was to bring together a series of essays which would define our present understanding of the endosome and lysosome and their interrelationship. The editors deliberately encouraged the contributors to be speculative; to strive to put order to the "real" world of incomplete and sometimes conflicting data. Seeing science from the laboratory bench can often be like viewing an impressionistic painting from up close; a series of paint dabs with no apparent order. The contributors to this volume were asked to step back and leave the reader with a sense of the whole as well as the detail. To the extent that this has happened, the credit should go to the individual authors. Our understanding of endosomes and lysosomes has undergone a molecular revolution over the last decade. Hence, we now know much about the molecular features required for internalization of an endocytic receptor, or the function of mannose 6-phosphate receptors in the transport of lysosomal enzymes. We can trace and follow the flow of molecules. In this volume current molecular knowledge concerning the function and relationship of endosomes and lysosomes is presented. Because of this vast increase in knowledge of molecules, we have realized that endosomes in particular are very ephemeral organelles. In fact, endosomes may well not be discrete entities but rather continuously changing and evolving in their molecular composition. The dynamic nature of the relationship between endosomes and lysosomes is the unifying focus of the genetic, biochemical, microscopic, and molecular biological approaches described in the chapters which follow.

Table of Contents

List of Contributors

Introduction to the Series

preface

Models of Endosome and Lysosome Traffic

Endocytic Receptors

Functions of the Mannose 6-Phosphate Receptors

Chemistry of Lysosomal Cysteine Proteinases

Mechanism and Regulation of Autophagic Degradation of Cellular Proteins

Cell-Free Systems for Endocytosis

Genetic Analysis of Membrane Traffic in Mammalian Cells

Plasma Membrane Lipid Transport in Cultured Cells: Studies using Lipid Analogs and Model Systems

Endosomes, Lysosomes, and Trans-Golgi-Related Systems in Conventional Neurons and the Frog Retina: Shards and Suppositions

The Role of Endocytosis in Epidermal Growth Factor Signaling

Membrane Traffic through the late Stages of the Yeast Secretory Pathway

Regulation of Lysosomal Trafficking and Function during Growth and Development of Dictyostelium Discoideum

Towards an Understanding of the Inheritance of Mammalian Lysosomes and Yeast Vacuoles

Index

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