Endothelial Dysfunctions and Vascular Disease

by Editor: Raffaele De Caterina (CNR Institute of Clinical Physiology, Pisa); Editor: Peter Libby (Harvard Medical School)

• ISBN13: 9781405122085
• ISBN10: 1405122080
• Edition: 1st
• Format: Hardcover
• Copyright: 2007-04-01
• Publisher: Wiley-Blackwell

Summary

The vascular endothelium performs a wide array of homeostatic functions within normal blood vessels. Vasoactive functions can be performed locally by the vascular endothelium. This book focuses on this cutting edge clinically relevent knowledge. Edited by two brilliant cardiovascular clinicians, this book embraces the basis of endothelial involvement in vascular disease and continues to elucidate risk factors, diagnostic tools and markers, and has a major section on prevention and therapy. This book represents the bridge from the laboratory to bedside.

Author Biography

Raffaele De Caterina, MD. Director, Laboratory for Thrombosis and Vascular Research, CNR Institute of Clinical Physiology, Pisa

Dr. Peter Libby, MD. Chief, Cardiovascular Medicine, Brigham and Women's Hospital. Mallinckrodt Professor of Medicine, Harvard Medical School

Table of Contents

Contributors	p. vii
Preface	p. x
Foreword	p. xi
Acknowledgments	p. xiii
Dedication	p. xiv
The basis of endothelial involvement in vascular diseases	p. 1
Endothelial functions and dysfunctions	p. 3
Endothelial activation and the initiation of atherosclerosis	p. 26
Mechanisms of plaque progression and complications	p. 36
Angiogenesis in cardiovascular disease	p. 55
The endothelium and cardiovascular risk factors	p. 85
VLDL and atherosclerosis	p. 87
High-density lipoprotein and atheroprotection	p. 95
Advanced glycation endproducts and the accelerated atherosclerosis in diabetes	p. 108
Homocysteine and endothelial dysfunction	p. 129
Lipoprotein (a) and the artery wall	p. 140
Oxidative stress and vascular disease	p. 148
Infections and vascular disease	p. 165
Diagnostic tools and markers of endothelial functions	p. 177
Endothelial vasodilatory dysfunction: basic concepts and practical implementation	p. 179
Endothelial vasodilatory dysfunction and risk factors in adults	p. 189
Endothelial vasodilatory dysfunction in early life	p. 199
Endothelial vasodilatory dysfunction in hypertension	p. 213
Vascular function and diabetes mellitus	p. 232
Dyslipidemia and endothelial dysfunction: pathophysiology and therapy	p. 245
Soluble adhesion molecules as in vivo biohumoral markers of vascular cell activation	p. 258
Endothelium-directed prevention and therapy	p. 273
Hormone replacement therapy and cardiovascular disease	p. 275
Anti-atherogenic effects of omega-3 fatty acids	p. 286
Treatment of endothelial dysfunction and atherosclerosis by cholesterol lowering	p. 300
Antioxidants and endothelial protection	p. 315
Angiotensin-converting enzyme inhibitors and angiotensin II type 1 receptor blockers to reverse endothelial dysfunction	p. 323
PPARs in atherosclerosis	p. 337
Stem cells in atherosclerosis and atherosclerosis-related vascular disorders	p. 350
Endothelium-targeted gene and cell-based therapy for cardiovascular disease	p. 365
Index	p. 401
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