Enzyme-Mediated Resistance to Antibiotics

by Bonomo, Robert A.; Tolmasky, Marcelo E.

• ISBN13: 9781555813031
• ISBN10: 1555813038
• Edition: 1st
• Format: Hardcover
• Copyright: 2007-05-07
• Publisher: Amer Society for Microbiology

Summary

Case Western Reserve Univ., Cleveland, OH. Provides an overview of enzyme-mediated resistance to antibiotics. Topics include enzymes in defense of the bacterial ribosome, enzymes in defense of the bacterial cell wall, dissemination of antibiotic resistance and its biological cost, and more. For researchers. DNLM: Anti-Bacterial Agents.

Table of Contents

Overview of aminoglycosides and enzyme-mediated bacterial resistance : clinical implications	p. 3
Aminoglycoside antibiotics	p. 7
Structural aspects of aminoglycoside-modifying enzymes	p. 21
Aminoglycoside-modifying enzymes : characteristics, localization, and dissemination	p. 35
rRNA methylases and resistance to macrolide, lincosamide, streptogramin, ketolide, and oxazolidinone (MLSKO) antibiotics	p. 53
[beta]-lactamases : historical perspectives	p. 67
Resistance mediated by penicillin-binding proteins	p. 81
Inhibition of class A [beta]-lactamases	p. 101
Class B [beta]-lactamases	p. 115
Crystal structures of class C [beta]-lactamases : mechanistic implications and perspectives in drug design	p. 145
Class D [beta]-lactamases	p. 163
Kinetics of [beta]-lactamases and penicillin-binding proteins	p. 195
The pharmaceutical industry and inhibitors of bacterial enzymes : implications for drug development	p. 217
[beta]-lactamase inhibitory proteins	p. 227
Active drug efflux in bacteria	p. 235
Overview of dissemination mechanisms of genes coding for resistance to antibiotics	p. 267
Conjugative transposons	p. 271
The dissemination of antibiotic resistance by bacterial conjugation	p. 285
Bacterial toxin-antitoxin systems as targets for the development of novel antibiotics	p. 313
Integrons and superintegrons	p. 331
The biological cost of antibiotic resistance	p. 339
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