This is the 13th volume in the Enzymology and Molecular Biology of Carbonyl Metabolism series. Within the text, the reader is given further valuable insight into Carbonyl Metabolism. This collection is the largest in its field of study and provides the deepest look into just three gene families. Through dozens of articles, molecular biological techniques are discussed, examining ways in which they are influencing the direction of research on Aldehyde Dehydrogenase, Alcohol Dehydrogenase, and Reductases. Book jacket.

Henry Weiner is a professor of Biochemistry at Purdue University. Dr Weiner obtained his Ph.D. from Purdue University in 1963. His area of study currently includes protein trafficking and the enzymology of aldehyde dehydrogenasess.

Aldehyde Dehydrogenases
Can We Change the Rate-Limiting Step of an Aldehyde Dehydrogenase?	p. 3
Unexpected Encounters in Simulations of the ALDH Mechanism	p. 9
Inhibitory Effects of Disulfiram and Its Metabolites on Pseudomonas aeruginosa Betaine Aldehyde Dehydrogenase and Growth	p. 14
Reversible Inactivation of Mitochondrial Aldehyde Dehydrogenase through Post-Translational Modifications in Hepatoma Cells and Alcohol-Fed Rat Livers	p. 22
Inhibition of Mitochondrial Aldehyde Dehydrogenase-Mediated Oxidation of 3,4-Dihydroxyphenylacetaldehyde	p. 33
Trans-4-hydroxy-2-nonenal (HNE), a Biochemical Tool (...as Well as a Toxin)	p. 40
Detoxification of Chloroacetaldehyde by Human Class-9 Aldehyde Dehydrogenase (ALDH9A1)	p. 44
Identification of Polymorphic Human Class-3 Aldehyde Dehydrogenases	p. 53
Phylogenetic and Structural Relationships of the Betaine Aldehyde Dehydrogenases	p. 64
Ionic Strength Dependency of Urea Effect on Renal Betaine Aldehyde Dehydrogenase Stability	p. 77
Effects of Monovalent Cations on the Structure and Thermal Stability of Betaine Aldehyde Dehydrogenase from Pseudomonas aeruginosa	p. 83
ALDH3A1 Expression Is Modulated by Docosahexaenoic Acid through Peroxisome Proliferator-Activated Receptors (PPARs) in Human Lung Adenocarcinoma Cells	p. 91
The "Asian" Variant Equivalent of Yeast Aldehyde Dehydrogenase Can Inactivate the Active Yeast Enzyme in vivo: A Knock-in Type Experiment Using Yeast to Mimic Liver Cells	p. 99
A Hepatocyte Inflammation Model for Carbonyl Induced Liver Injury: Drugs, Diabetes, Solvents, Chlorination	p. 105
Therapeutic Intracellular Targets for Preventing Carbonyl Cell Death with B Vitamins or Drugs	p. 113
Alcohol Dehydrogenases
Recombinant Mouse Alcohol Dehydrogenase 1: Kinetic Mechanism, Substrate Specificity and Oxidation of 20-Hydroxyeicosatetraenoic Acid	p. 123
Functional Roles of Alcohol Dehydrogenases in Human Ethanol Metabolism	p. 134
Kinetic Analysis of SDRs, ADHs and AKRs toward Free and CRBPI-bound Retinoids: Effect of Tween-80 and Microsomal Membranes	p. 144
Structural and Functional Features of Cinnamyl Alcohol Dehydrogenase (Adh6p) from Saccharomyces cerevisiae	p. 152
Diversity of Beta-Hydroxyacid Dehydrogenases in Plants	p. 160
Carbonyl Reductases
Multifunctional Carbonyl Reductases of the Short-Chain Dehydrogenase/Reductase (SDR) Superfamily in Mammalian Species	p. 169
The Aldo-Keto Reductase Superfamily Homepage: 2006 Update	p. 184
Life without Aldose Reductase	p. 198
Species Comparison of AKR7A Family Members	p. 209
Retinoid-Active Short-Chain Dehydrogenases/Reductases	p. 217
Crystal Structure of Pig Heart Carbonyl Reductase	p. 224
Lead Optimization in the Design of Aldose Reductase Inhibitors	p. 231
Selective Inhibitors of AKR1C3 as Anti-Proliferative Agents	p. 242
AKR1C1 and AKR1C3 as Potential Targets for Phytoestrogen Action	p. 252
Searching for Inhibitors of Fungal 17[Beta]-Hydroxysteroid Dehydrogenase	p. 263
Conversion of AKR1C20 into an AKR1C6-Type Enzyme by Site-Directed Mutagenesis	p. 273
A Comparison of Methods for Assays of Steroidogenic Enzymes: New GC/MS versus HPLC and TLC	p. 281
Purification of Aldo-keto Reductase AKR1B10 from Human Liver and Its Participation in the Carbonyl Reduction of Xenobiotics	p. 288
Characterization of Guinea Pig Liver D-Xylulose Reductase of the Uronate Pathway: Identity with Sorbitol Dehydrogenase	p. 296
Fungal Mannitol 2-Dehydrogenases and Mannitol-1-Phosphate 5-Dehydrogenases Constitute Novel Branches in the Protein Family of Polyol-Specific Long-Chain Dehydrogenases and Reductases	p. 305
Relative Efficacy of Aldo-keto Reductases in Catalyzing the Reduction of Phospholipid Aldehydes	p. 323
[Delta superscript 4]-3-Ketosteroid 5[Beta]-Reductase (AKR1D1): Properties and Role in Bile Acid Synthesis	p. 332
Metabolism of 4-Hydroxy-trans-2-Nonenal (HNE)-Modified Proteins in Vascular Smooth Muscle Cells	p. 341
Are 17[Beta]-HSDs Responsible for Increased Estradiol Concentrations within Ectopic and Cancerous Endometrium?	p. 350
Regulation of Promoter Activity of the Aldose Reductase Gene Through the Multiple Stress Response Region, MSRR	p. 360
Expression of Carbonyl Reductases in Fetal Human Brain, but Not in Adult	p. 368
Aldose Reductase Mediates Endotoxin-induced Cardiomyopathy and Septic Shock via Reduction of Lipid Aldehydes	p. 379
Modulation of Gamma-Hydroxybutyrate Induced Sleep Using Hepatic AKR7A5 and AKR1A4 Inhibitors	p. 389
Aldose Reductase Inhibition Prevents Lipopolysaccharide-Induced NF-[Kappa]B Signaling in Human Lens Epithelial Cells	p. 394
Catalytic Activity of the [Beta]-Subunits of Voltage-sensitive Potassium Channels and Its Regulation by Pyridine Nucleotides	p. 401
Index	p. 411
Table of Contents provided by Ingram. All Rights Reserved.

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