Epidemiological and Molecular Aspects on Cholera

by Ramamurthy, T.; Bhattacharya, S. K.

• ISBN13: 9781603272643
• ISBN10: 160327264X
• Edition: 1st
• Format: Hardcover
• Copyright: 2010-10-15
• Publisher: Springer Verlag

Summary

Though cholera is an ancient disease, its perennial occurrence all over the world has compelled many researchers to find new ways and means to combat it. Since the seventh cholera pandemic, which began in 1961, the genetic structure and functions of Vibrio cholerae have radically changed. Several recent studies have shown that, with successive new clones of V. cholerae, the transformation of the pathogen at the molecular level has ameliorated several cholera outbreaks and epidemics.

Table of Contents

General Introduction	p. 1
Asiatic Cholera: Mole Hills and Mountains	p. 5
Endemic and Epidemic Cholera in Africa	p. 31
Phenotypic and Molecular Characteristics of Epidemic and Non-epidemic Vibrio cholerae Strains Isolated in Russia and Certain Countries of Commonwealth of Independent States (CIS)	p. 51
The Re-emergence of Cholera in the Americas	p. 79
The Evolution of Vibrio cholerae as a Pathogen	p. 97
Molecular Epidemiology of Toxigenic Vibrio cholerae	p. 115
Diversity and Genetic Basis of Polysaccharide Biosynthesis in Vibrio cholerae	p. 129
Significance of the SXT/R391 Family of Integrating Conjugative Elements in Vibrio cholerae	p. 161
Small Molecule Signaling Systems in Vibrio cholerae	p. 185
Vibrio cholerae Flagellar Synthesis and Virulence	p. 203
Filamentous Phages of Vibrio cholerae 01 and 0139	p. 213
Pathogenic Potential of Non-01, Non-0139 Vibrio cholerae	p. 223
Proteases Produced by Vibrio cholerae and Other Pathogenic Vibrios: Pathogenic Roles and Expression	p. 245
Toxins of Vibrio cholerae and Their Role in Inflammation, Pathogenesis, and Immunomodulation	p. 259
Vibrio cholerae Hemolysin: An Enigmatic Pore-Forming Toxin	p. 277
Integron-Mediated Antimicrobial Resistance in Vibrio cholerae	p. 291
Aquatic Realm and Cholera	p. 311
Management of Cholera	p. 341
Subject Index	p. 355
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