The Epidemiology of Schizophrenia

by Edited by Robin M. Murray , Peter B. Jones , Ezra Susser , Jim Van Os , Mary Cannon

• ISBN13: 9780521775403
• ISBN10: 052177540X
• Format: Hardcover
• Copyright: 2003-01-13
• Publisher: Cambridge University Press

Summary

An international team of leading researchers and clinicians here provide the first comprehensive, epidemiological overview of this multi-faceted and still perplexing disorder, and address some of the key questions it raises. How important in the genetic contribution to schizophrenia? Do pregnancy and birth complications increase the risk for schizophrenia? Is the incidence of schizophrenia changing? Why is the rate higher among immigrants and in those born in cities? Controversial issues such as the validity of discrete or dimensional classifications of schizophrenia and the continuum between psychosis and 'normality' are explored in depth, and separate chapters are devoted to topics of particular relevance to schizophrenia such as suicide, violence and substance abuse. Finally, new prospects for treatment and prevention are considered. Drawing together the findings from social, genetic, developmental and classical epidemiology of schizophrenia, this text will prove an invaluable resource for clinicians and researchers.

Table of Contents

List of contributors	viii
Preface	xiii
Foreword	xv
William Carpenter
I The social epidemiology of schizophrenia
Introduction	3	(2)
Investigating socioenvironmental influences in schizophrenia: conceptual and design issues	5	(13)
Michaeline Bresnahan
Ezra Susser
Geographical variation in incidence, course and outcome of schizophrenia: a comparison of developing and developed countries	18	(16)
Michaeline Bresnahan
Paulo Menezes
Vijoy Varma
Ezra Susser
Temporal variation in the incidence, course and outcome of schizophrenia	34	(15)
Michaeline Bresnahan
Jane Boydell
Robin Murray
Ezra Susser
Urbanization, migration and risk of schizophrenia	49	(25)
Jane Boydell
Robin Murray
II The developmental epidemiology of schizophrenia
Introduction	71	(3)
Prenatal and perinatal risk factors for schizophrenia	74	(26)
Mary Cannon
Robert Kendell
Ezra Susser
Peter Jones
Childhood development and later schizophrenia: evidence from genetic high-risk and birth cohort studies	100	(24)
Mary Cannon
C. Jane Tarrant
Matti O. Huttunen
Peter Jones
Prodrome, onset and early course of schizophrenia	124	(24)
Heinz Hafner
The value of first-episode studies in schizophrenia	148	(19)
Mary Clarke
Eadbhard O'Callaghan
Schizophrenia at the extremes of life	167	(27)
Kenneth G. D. Orr
David J. Castle
III The genetic epidemiology of schizophrenia
Introduction	193	(1)
The `classical' genetic epidemiology of schizophrenia	194	(26)
Alastair Cardno
Robin M. Murray
Molecular genetics and epidemiology in schizophrenia: a necessary partnership	220	(15)
Stanley Zammit
Glyn Lewis
Michael J. Owen
Gene-environment correlation and interaction in schizophrenia	235	(19)
Jim van Os
Pak Sham
Investigating gene-environment interaction in schizophrenia using neuroimaging	254	(21)
Theo G. M. van Erp
Timothy L. Gasperoni
Isabelle M. Rosso
Tyrone D. Cannon
IV Special issues in the epidemiology of schizophrenia
Introduction	273	(2)
Mortality and physical illness in schizophrenia	275	(13)
Preben Bo Mortensen
The clinical epidemiology of suicide in schizophrenia	288	(29)
Hannele Heila
Jouko Lonnqvist
What is the relationship between substance abuse and schizophrenia?	317	(26)
Robin M. Murray
Anton Grech
Peter Phillips
Sonia Johnson
Criminal and violent behaviour in schizophrenia	343	(21)
Elizabeth Walsh
Alec Buchanan
V Future directions and emerging issues
Introduction	363	(1)
Diagnosis and classification of schizophrenia: categories versus dimensions, distributions versus disease	364	(47)
Jim van Os
Helene Verdoux
The implications of epidemiology for service planning in schizophrenia	411	(16)
Graham Thornicroft
Michele Tansella
Prevention of schizophrenia - not an impossible dream	427	(14)
John McGrath
Glossary of epidemiological terms	441	(6)
Index	447